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Toward clinically a...
Toward clinically applicable biomarkers for asthma : An EAACI position paper
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- Diamant, Zuzana (författare)
- Skane Univ Hosp, Inst Clin Sci, Dept Resp Med & Allergol, Lund, Sweden; Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands; QPS NL, Groningen, Netherlands; Charles Univ Prague, Fac Med 1, Dept Resp Med, Prague, Czech Republic; Thomayer Hosp, Prague, Czech Republic
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- Vijverberg, Susanne (författare)
- Univ Amsterdam, Amsterdam UMC, Dept Resp Med, Amsterdam, Netherlands
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- Alving, Kjell, 1959- (författare)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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- Bakirtas, Arzu (författare)
- Gazi Univ, Sch Med, Div Pediat Allergy & Asthma, Dept Pediat, Ankara, Turkey
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- Bjermer, Leif (författare)
- Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands; QPS NL, Groningen, Netherlands
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- Custovic, Adnan (författare)
- Imperial Coll London, Dept Med, Sect Paediat, London, England
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- Dahlen, Sven-Erik (författare)
- Karolinska Institutet
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- Gaga, Mina (författare)
- Athens Chest Hosp, Resp Med Dept 7, Athens, Greece; Athens Chest Hosp, Asthma Ctr, Athens, Greece
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- van Wijk, Roy Gerth (författare)
- Erasmus MC, Dept Internal Med, Sect Allergol, Rotterdam, Netherlands
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- Del Giacco, Stefano (författare)
- Univ Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Italy
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- Hamelmann, Eckard (författare)
- Protestant Hosp Bethel, Childrens Ctr, Bielefeld, Germany; Ruhr Univ Bochum, Allergy Ctr, Bochum, Germany
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- Heaney, Liam G. (författare)
- Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Expt Med, Belfast, Antrim, North Ireland
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- Heffler, Enrico (författare)
- Humanitas Univ, Dept Biomed Sci, Milan, Italy; Humanitas Res Hosp, Personalized Med Asthma & Allergy, Milan, Italy
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- Kalayci, Omer (författare)
- Hacettepe Univ, Fac Med, Div Pediat Allergy, Ankara, Turkey
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- Kostikas, Konstantinos (författare)
- Univ Ioannina, Med Sch, Resp Med Dept, Ioannina, Greece
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- Lutter, Rene (författare)
- Univ Amsterdam, Amsterdam UMC, Dept Resp Med, Amsterdam, Netherlands
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- Olin, Anna-Carin, 1960 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
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- Sergejeva, Svetlana (författare)
- Univ Tartu, Inst Technol, Tartu, Estonia
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- Simpson, Angela (författare)
- Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Div Infect Immun & Resp Med, Manchester, Lancs, England; South Manchester NHS Fdn Trust, Univ Hosp, Manchester, Lancs, England
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- Sterk, Peter J. (författare)
- Univ Amsterdam, Amsterdam UMC, Dept Resp Med, Amsterdam, Netherlands
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- Tufvesson, Ellen (författare)
- Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands; QPS NL, Groningen, Netherlands
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- Agache, Ioana (författare)
- Transylvania Univ Brasov, Fac Med, Dept Allergy & Clin Immunol, Brasov, Romania
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- Seys, Sven F. (författare)
- Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Allergy & Clin Immunol Res Grp, Leuven, Belgium
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Kalayci,, Kalayci, (författare)
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(creator_code:org_t)
- 2019-10-25
- 2019
- Engelska.
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 74:10, s. 1835-1851
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Inflammation, structural, and functional abnormalities within the airways are key features of asthma. Although these processes are well documented, their expression varies across the heterogeneous spectrum of asthma. Type 2 inflammatory responses are characterized by increased levels of eosinophils, FeNO, and type 2 cytokines in blood and/or airways. Presently, type 2 asthma is the best-defined endotype, typically found in patients with allergic asthma, but surprisingly also in nonallergic patients with (severe) asthma. The etiology of asthma with non-type 2 inflammation is less clear. During the past decade, targeted therapies, including biologicals and small molecules, have been increasingly integrated into treatment strategies of severe asthma. These treatments block specific inflammatory pathways or single mediators. Single or composite biomarkers help to identify patients who will benefit from these treatments. So far, only a few inflammatory biomarkers have been validated for clinical application. The European Academy of Allergy & Clinical Immunology Task Force on Biomarkers in Asthma was initiated to review different biomarker sampling methods and to investigate clinical applicability of new and existing inflammatory biomarkers (point-of-care) to support diagnosis, targeted treatment, and monitoring of severe asthma. Subsequently, we discuss existing and novel targeted therapies for asthma as well as applicable biomarkers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- endotype
- eosinophil
- FeNO
- IgE
- phenotype
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Diamant, Zuzana
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Vijverberg, Susa ...
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Alving, Kjell, 1 ...
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Bakirtas, Arzu
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Bjermer, Leif
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Custovic, Adnan
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visa fler...
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Dahlen, Sven-Eri ...
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Gaga, Mina
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van Wijk, Roy Ge ...
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Del Giacco, Stef ...
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Hamelmann, Eckar ...
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Heaney, Liam G.
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Heffler, Enrico
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Kalayci, Omer
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Kostikas, Konsta ...
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Lutter, Rene
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Olin, Anna-Carin ...
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Sergejeva, Svetl ...
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Simpson, Angela
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Sterk, Peter J.
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Tufvesson, Ellen
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Agache, Ioana
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Seys, Sven F.
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Kalayci,, Kalayc ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
- Artiklar i publikationen
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Allergy. Europea ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Göteborgs universitet