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- Helte, EmilieKarolinska Institutet,Karolinska Inst, Inst Environm Med, Unit Nutr & Cardiovasc Epidemiol, Stockholm, Sweden (författare)
Assessing Causality in Associations of Serum Calcium and Magnesium Levels With Heart Failure : A Two-Sample Mendelian Randomization Study
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
- 2019-10-23
- FRONTIERS MEDIA SA,2019
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-397594
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397594URI
- https://doi.org/10.3389/fgene.2019.01069DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:142203488URI
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- Språk:engelska
- Sammanfattning på:engelska
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- Evidence from observational studies suggests that increased exposure to calcium may increase the risk of coronary heart disease and stroke whereas magnesium might have a protective effect on disease risk. However, studies of the associations of these minerals with heart failure are scarce and limited by potential biases introduced by confounding and reverse causality. We applied a two-sample Mendelian randomization design using summary estimates to assess whether serum calcium and magnesium concentrations are causally associated with heart failure. Summary statistics data were collected for seven and six single-nucleotide polymorphisms associated with calcium and magnesium, respectively, from the hitherto largest genome-wide association studies on these minerals. Corresponding summary statistics for genetic associations with heart failure were available from publicly available data based on the UK Biobank study and based on participants of European ancestry. The findings showed that neither serum calcium nor magnesium concentrations were associated with heart failure. In the standard inverse-variance weighted analysis, the odds ratios of heart failure per genetically predicted one standard deviation increase in mineral concentrations were 0.89 (95% confidence interval 0.67-1.17; p = 0.41) for serum calcium and 0.89 (95% confidence interval 0.72-1.10; p = 0.28) for serum magnesium. Results were robust in sensitivity analyses, including the weighted median and Mendelian randomization Egger analyses. In conclusion, these findings do not support previous findings suggesting a link between serum calcium and magnesium and heart failure, but this study was underpowered to detect weak associations.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
- calcium
- heart failure
- magnesium
- minerals
- Mendelian randomization
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Akesson, AgnetaKarolinska Institutet,Karolinska Inst, Inst Environm Med, Unit Nutr & Cardiovasc Epidemiol, Stockholm, Sweden (författare)
- Larsson, Susanna C.Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Nutr & Cardiovasc Epidemiol, Stockholm, Sweden(Swepub:uu)susla720 (författare)
- Karolinska InstitutetKarolinska Inst, Inst Environm Med, Unit Nutr & Cardiovasc Epidemiol, Stockholm, Sweden (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Frontiers in Genetics: FRONTIERS MEDIA SA101664-8021
Internetlänk
- https://doi.org/10.3389/fgene.2019.01069Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1372373/FULLTEXT01.pdffulltext:print
- https://www.frontiersin.org/articles/10.3389/fgene.2019.01069/pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397594
- https://doi.org/10.3389/fgene.2019.01069
- http://kipublications.ki.se/Default.aspx?queryparsed=id:142203488
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