Sökning: WFRF:(Troisi Rebecca) >
Associations of pre...
Associations of pregnancy-related factors and birth characteristics with risk of endometrial cancer : A Nordic population-based case-control study
-
- Trabert, Britton (författare)
- Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD.
-
- Troisi, Rebecca (författare)
- Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD.
-
- Grotmol, Tom (författare)
- Cancer Registry of Norway, Oslo, Norway.
-
visa fler...
-
- Ekbom, Anders (författare)
- Karolinska Institutet,Department of Medicine, Division of Clinical Epidemiology, Karolinska Institutet, Stockholm, Sweden.
-
- Engeland, Anders (författare)
- Division of Mental and Physical Health, Norwegian Institute of Public Health, Bergen, Norway.; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
-
- Gissler, Mika (författare)
- Karolinska Institutet,Information Services Department, National Institute for Health and Welfare (THL), Helsinki, Finland.; Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
-
- Glimelius, Ingrid, 1975- (författare)
- Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi,Department of Medicine, Division of Clinical Epidemiology, Karolinska Institutet, Stockholm, Sweden
-
- Madanat-Harjuoja, Laura (författare)
- Cancer Society of Finland, Finnish Cancer Registry, Helsinki, Finland.; Department of Pediatrics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
-
- Sørensen, Henrik Toft (författare)
- Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
-
- Tretli, Steinar (författare)
- Cancer Registry of Norway, Oslo, Norway.
-
- Gulbech Ording, Anne (författare)
- Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
-
- Bjørge, Tone (författare)
- Cancer Registry of Norway, Oslo, Norway.; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
-
visa färre...
-
Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD Cancer Registry of Norway, Oslo, Norway. (creator_code:org_t)
- 2019-06-20
- 2020
- Engelska.
-
Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 146:6, s. 1523-1531
- Relaterad länk:
-
https://bora.uib.no/...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Many pregnancy-related factors are associated with reduced endometrial cancer risk. However, it remains unclear whether pregnancy-related complications (e.g., hypertensive conditions) are associated with risk and whether these associations vary by endometrial cancer subtype. Thus, we evaluated the risk of endometrial cancer, overall and by subtype, in relation to pregnancy-related factors, pregnancy complications and birth characteristics. Utilizing population-based register data from four Nordic countries, we conducted a nested case-control analysis of endometrial cancer risk. We included 10,924 endometrial cancer cases and up to 10 matched controls per case. Odds ratios (ORs) with 95% confidence intervals (CIs) were derived from unconditional logistic regression models. We further evaluated associations by individual histology (i.e., endometrioid, serous, etc.) or, for rare exposures (e.g., pregnancy complications), by dualistic type (Type I [n = 10,343] and Type II [n = 581]). Preexisting and pregnancy-related hypertensive conditions were associated with increased endometrial cancer risk (OR [95% CI]: preexisting hypertension 1.88 [1.39-2.55]; gestational hypertension 1.47 [1.33-1.63]; preeclampsia 1.43 [1.30-1.58]), with consistent associations across dualistic type. Increasing number of pregnancies (≥4 vs. 1 birth: 0.64 [0.59-0.69]) and shorter time since last birth (<10 vs. ≥30 years: 0.34 [0.29-0.40]) were associated with reduced endometrial cancer risk, with consistent associations across most subtypes. Our findings support the role for both hormonal exposures and cell clearance as well as immunologic/inflammatory etiologies for endometrial cancer. This research supports studying endometrial hyperplasia, a precursor condition of endometrial cancer, in the context of pregnancy-related exposures, as this may provide insight into the mechanisms by which pregnancy affects subsequent cancer risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Nordic countries
- endometrial cancer
- hypertension
- preeclampsia
- pregnancy timing
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Trabert, Britton
-
Troisi, Rebecca
-
Grotmol, Tom
-
Ekbom, Anders
-
Engeland, Anders
-
Gissler, Mika
-
visa fler...
-
Glimelius, Ingri ...
-
Madanat-Harjuoja ...
-
Sørensen, Henrik ...
-
Tretli, Steinar
-
Gulbech Ording, ...
-
Bjørge, Tone
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reproduktionsmed ...
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet