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- Månsson, Christopher,Läkarexamen,1977-Uppsala universitet,Gastrointestinalkirurgi (author)
The Value of CA19-9 After Irreversible Electroporation for Pancreatic Cancer
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- 2019-11-08
- Anticancer Research USA Inc.2019
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- LIBRIS-ID:oai:DiVA.org:uu-397945
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397945URI
- https://doi.org/10.21873/anticanres.13827DOI
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- Language:English
- Summary in:English
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- Background/Aim:Carbohydrate antigen 19-9 (CA19-9) is a tumor marker for pancreatic cancer. Irreversible electroporation (IRE) is an experimental treatment modality for pancreatic cancer. The aim of this study was to evaluate whether percutaneous IRE lowers the CA19-9 level in pancreatic cancer and whether this correlates with improved overall survival.Patients and Methods:Seventy-one patients with locally advanced pancreatic cancer or local recurrence after resection were treated. Patients with missing data, metastatic disease and normal serum CA19-9 before IRE were excluded. This left 35 cases for analysis.Results:The median CA19-9 did not decrease in the cohort after IRE treatment (282 U/ml before versus 315 U/ml after; p=0.80). The 25th percentile of patients with the best CA19-9 response had improved overall survival compared to the 25th percentile with the worst response (mean 13.1 versus 8.1 months, respectively; p=0.01).Conclusion:IRE did not lower the level of CA19-9 in pancreatic cancer cases. However, a response in CA19-9 was correlated with improved survival.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
- Pancreatic neoplasms
- electroporation
- interventional ultrasonography
- CA19-9
Added entries (persons, corporate bodies, meetings, titles ...)
- Nilsson, Anders,1958-Uppsala universitet,Radiologi(Swepub:uu)annil021 (author)
- Urdzik, JozefUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)jozur974 (author)
- Karlson, Britt-MarieUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)bmakarl (author)
- Uppsala universitetGastrointestinalkirurgi (creator_code:org_t)
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- In:Anticancer Research: Anticancer Research USA Inc.39:11, s. 6193-61960250-70051791-7530
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