Search: WFRF:(Hedlund Lena)
> (2015-2019) >
Myc-dependent endot...
Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2
-
- Testini, Chiara (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi
-
- Smith, Ross O. (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi
-
- Jin, Yi (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab
-
show more...
-
- Martinsson, Pernilla (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi
-
- Sun, Ying (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab
-
- Hedlund, Marie (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi
-
- Sáinz-Jaspeado, Miguel (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab
-
- Shibuya, Masabumi (author)
- Jobu Univ, Inst Physiol & Med, Takasaki, Gunma, Japan
-
- Hellström, Mats (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
-
- Claesson-Welsh, Lena (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi
-
show less...
-
(creator_code:org_t)
- 2019-09-23
- 2019
- English.
-
In: EMBO Reports. - : EMBO. - 1469-221X .- 1469-3178. ; 20:11
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Exaggerated signaling by vascular endothelial growth factor (VEGF)-A and its receptor, VEGFR2, in pathologies results in poor vessel function. Still, pharmacological suppression of VEGFA/VEGFR2 may aggravate disease. Delineating VEGFR2 signaling in vivo provides strategies for suppression of specific VEGFR2-induced pathways. Three VEGFR2 tyrosine residues (Y949, Y1212, and Y1173) induce downstream signaling. Here, we show that knock-in of phenylalanine to create VEGFR2 Y1212F in C57Bl/6 and FVB mouse strains leads to loss of growth factor receptor-bound protein 2- and phosphoinositide 3′-kinase (PI3K)p85 signaling. C57Bl/6 Vegfr2Y1212F/Y1212F show reduced embryonic endothelial cell (EC) proliferation and partial lethality. FVB Vegfr2Y1212F/Y1212F show reduced postnatal EC proliferation. Reduced EC proliferation in Vegfr2Y1212F/Y1212F explants is rescued by c-Myc overexpression. We conclude that VEGFR2 Y1212 signaling induces activation of extracellular-signal-regulated kinase (ERK)1/2 and Akt pathways required for c-Myc-dependent gene regulation, endothelial proliferation, and vessel stability.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- angiogenesis
- GRB2
- Nck
- PI3Kp85
- proliferation
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Testini, Chiara
-
Smith, Ross O.
-
Jin, Yi
-
Martinsson, Pern ...
-
Sun, Ying
-
Hedlund, Marie
-
show more...
-
Sáinz-Jaspeado, ...
-
Shibuya, Masabum ...
-
Hellström, Mats
-
Claesson-Welsh, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
EMBO Reports
- By the university
-
Uppsala University