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  • Li, YanShanghai Jiao Tong Univ, Sch Med, Ctr Epidemiol Studies, Shanghai, Peoples R China;Shanghai Jiao Tong Univ, Clin Trials & Ctr Vasc Evaluat, Shanghai Inst Hypertens, Shanghai Key Lab Hypertens,Ruijin Hosp, Shanghai, Peoples R China (author)

Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • Lippincott Williams & Wilkins,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-398690
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-398690URI
  • https://doi.org/10.1161/HYPERTENSIONAHA.119.12958DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:142375297URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Participant-level meta-analyses assessed the age-specific relevance of office blood pressure to cardiovascular complications, but this information is lacking for out-of-office blood pressure. At baseline, daytime ambulatory (n=12 624) or home (n=5297) blood pressure were measured in 17 921 participants (51.3% women; mean age, 54.2 years) from 17 population cohorts. Subsequently, mortality and cardiovascular events were recorded. Using multivariable Cox regression, floating absolute risk was computed across 4 age bands (<= 60, 61-70, 71-80, and >80 years). Over 236 491 person-years, 3855 people died and 2942 cardiovascular events occurred. From levels as low as 110/65 mm Hg, risk log-linearly increased with higher out-of-office systolic/diastolic blood pressure. From the youngest to the oldest age group, rates expressed per 1000 person-years increased (P<0.001) from 4.4 (95% CI, 4.0-4.7) to 86.3 (76.1-96.5) for all-cause mortality and from 4.1 (3.9-4.6) to 59.8 (51.0-68.7) for cardiovascular events, whereas hazard ratios per 20-mm Hg increment in systolic out-of-office blood pressure decreased (P <= 0.0033) from 1.42 (1.19-1.69) to 1.09 (1.05-1.12) and from 1.70 (1.51-1.92) to 1.12 (1.07-1.17), respectively. These age-related trends were similar for out-of-office diastolic pressure and were generally consistent in both sexes and across ethnicities. In conclusion, adverse outcomes were directly associated with out-of-office blood pressure in adults. At young age, the absolute risk associated with out-of-office blood pressure was low, but relative risk high, whereas with advancing age relative risk decreased and absolute risk increased. These observations highlight the need of a lifecourse approach for the management of hypertension.

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  • Thijs, LutgardeUniv Leuven, Dept Cardiovasc Sci, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium (author)
  • Zhang, Zhen-YuUniv Leuven, Dept Cardiovasc Sci, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium (author)
  • Asayama, KeiTeikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo, Japan;Tohoku Inst Management Blood Pressure, Sendai, Miyagi, Japan (author)
  • Hansen, Tine W.Steno Diabet Ctr Copenhagen, Gentofte, Denmark (author)
  • Boggia, JoseUniv Republica, Ctr Nefrol, Montevideo, Uruguay;Univ Republica, Dept Fisiopatol, Hosp Clin, Montevideo, Uruguay (author)
  • Bjoerklund-Bodegard, KristinaKarolinska Inst, Div Cardiovasc Med, Dept Clin Sci, Danderyd Hosp, Stockholm, Sweden (author)
  • Yang, Wen-YiUniv Leuven, Dept Cardiovasc Sci, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium (author)
  • Niiranen, Teemu J.Natl Inst Hlth & Welf, Turku, Finland;Turku Univ Hosp, Dept Med, Turku, Finland;Univ Turku, Turku, Finland (author)
  • Ntineri, AngelikiUniv Athens, Hypertens Ctr STRIDE 7, Sch Med, Sotiria Hosp,Dept Med 3, Athens, Greece (author)
  • Wei, Fang-FeiUniv Leuven, Dept Cardiovasc Sci, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium (author)
  • Kikuya, MasahiroTeikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo, Japan (author)
  • Ohkubo, TakayoshiTeikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo, Japan;Tohoku Inst Management Blood Pressure, Sendai, Miyagi, Japan (author)
  • Dolan, EamonStroke & Hypertens Unit, Dublin, Ireland (author)
  • Hozawa, AtsushiTohoku Univ, Tohoku Med Megabank Org, Dept Prevent Med & Epidemiol, Sendai, Miyagi, Japan (author)
  • Tsuji, IchiroTohoku Univ, Dept Publ Hlth, Grad Sch Med, Sendai, Miyagi, Japan (author)
  • Stolarz-Skrzypek, KatarzynaJagiellonian Univ, Dept Cardiol 1, Intervent Electrocardiol & Hypertens, Coll Med, Krakow, Poland (author)
  • Huang, Qi-FangShanghai Jiao Tong Univ, Sch Med, Ctr Epidemiol Studies, Shanghai, Peoples R China;Shanghai Jiao Tong Univ, Clin Trials & Ctr Vasc Evaluat, Shanghai Inst Hypertens, Shanghai Key Lab Hypertens,Ruijin Hosp, Shanghai, Peoples R China (author)
  • Melgarejo, Jesus D.Univ Zulia, Lab Neurociencias, Maracaibo, Venezuela;Univ Zulia, Inst Cardiovasc, Maracaibo, Venezuela (author)
  • Tikhonoff, ValerieUniv Padua, Dept Med, Padua, Italy (author)
  • Malyutina, SofiaRussian Acad Sci, Inst Internal & Prevent Med Internal & Prevent Me, Inst Cytol & Genet, Siberian Branch, Novosibirsk, Russia (author)
  • Casiglia, EdoardoUniv Padua, Dept Med, Padua, Italy (author)
  • Nikitin, YuriRussian Acad Sci, Inst Internal & Prevent Med Internal & Prevent Me, Inst Cytol & Genet, Siberian Branch, Novosibirsk, Russia (author)
  • Lind, LarsUppsala universitet,Geriatrik(Swepub:uu)larslind (author)
  • Sandoya, EdgardoAsociac Espanola Primera Socorros Mutuos, Montevideo, Uruguay (author)
  • Aparicio, LucasUniv Buenos Aires, Hosp Italiano Buenos Aires, Dept Med, Buenos Aires, DF, Argentina (author)
  • Barochiner, JessicaUniv Buenos Aires, Hosp Italiano Buenos Aires, Dept Med, Buenos Aires, DF, Argentina (author)
  • Gilis-Malinowska, NataszaMed Univ Gdansk, Dept Hypertens, Gdansk, Poland (author)
  • Narkiewicz, KrzysztofMed Univ Gdansk, Dept Hypertens, Gdansk, Poland (author)
  • Kawecka-Jaszcz, KalinaJagiellonian Univ, Dept Cardiol 1, Intervent Electrocardiol & Hypertens, Coll Med, Krakow, Poland (author)
  • Maestre, Gladys E.Univ Zulia, Lab Neurociencias, Maracaibo, Venezuela;Univ Zulia, Inst Cardiovasc, Maracaibo, Venezuela;Univ Texas Rio Grande Valley, Dept Neurosci, Brownsville, TX USA;Univ Texas Rio Grande Valley, Dept Human Genet, Brownsville, TX USA (author)
  • Jula, Antti M.Natl Inst Hlth & Welf, Turku, Finland (author)
  • Johansson, Jouni K.Natl Inst Hlth & Welf, Turku, Finland (author)
  • Kuznetsova, TatianaUniv Leuven, Dept Cardiovasc Sci, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium (author)
  • Filipovsky, JanCharles Univ Prague, Fac Med, Plzen, Czech Republic (author)
  • Stergiou, GeorgeUniv Athens, Hypertens Ctr STRIDE 7, Sch Med, Sotiria Hosp,Dept Med 3, Athens, Greece (author)
  • Wang, Ji-GuangShanghai Jiao Tong Univ, Sch Med, Ctr Epidemiol Studies, Shanghai, Peoples R China;Shanghai Jiao Tong Univ, Clin Trials & Ctr Vasc Evaluat, Shanghai Inst Hypertens, Shanghai Key Lab Hypertens,Ruijin Hosp, Shanghai, Peoples R China (author)
  • Imai, YutakaTohoku Inst Management Blood Pressure, Sendai, Miyagi, Japan (author)
  • O'Brien, EoinUniv Coll Dublin, Conway Inst, Dublin, Ireland (author)
  • Staessen, Jan A.Univ Leuven, Dept Cardiovasc Sci, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium;Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands (author)
  • Shanghai Jiao Tong Univ, Sch Med, Ctr Epidemiol Studies, Shanghai, Peoples R China;Shanghai Jiao Tong Univ, Clin Trials & Ctr Vasc Evaluat, Shanghai Inst Hypertens, Shanghai Key Lab Hypertens,Ruijin Hosp, Shanghai, Peoples R ChinaUniv Leuven, Dept Cardiovasc Sci, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium (creator_code:org_t)

Related titles

  • In:Hypertension: Lippincott Williams & Wilkins74:6, s. 1333-13420194-911X1524-4563

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