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Opposing Age-Relate...
Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure
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- Li, Yan (author)
- Shanghai Jiao Tong Univ, Sch Med, Ctr Epidemiol Studies, Shanghai, Peoples R China;Shanghai Jiao Tong Univ, Clin Trials & Ctr Vasc Evaluat, Shanghai Inst Hypertens, Shanghai Key Lab Hypertens,Ruijin Hosp, Shanghai, Peoples R China
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- Thijs, Lutgarde (author)
- Univ Leuven, Dept Cardiovasc Sci, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium
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- Zhang, Zhen-Yu (author)
- Univ Leuven, Dept Cardiovasc Sci, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium
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- Asayama, Kei (author)
- Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo, Japan;Tohoku Inst Management Blood Pressure, Sendai, Miyagi, Japan
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- Hansen, Tine W. (author)
- Steno Diabet Ctr Copenhagen, Gentofte, Denmark
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- Boggia, Jose (author)
- Univ Republica, Ctr Nefrol, Montevideo, Uruguay;Univ Republica, Dept Fisiopatol, Hosp Clin, Montevideo, Uruguay
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- Bjoerklund-Bodegard, Kristina (author)
- Karolinska Inst, Div Cardiovasc Med, Dept Clin Sci, Danderyd Hosp, Stockholm, Sweden
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- Yang, Wen-Yi (author)
- Univ Leuven, Dept Cardiovasc Sci, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium
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- Niiranen, Teemu J. (author)
- Natl Inst Hlth & Welf, Turku, Finland;Turku Univ Hosp, Dept Med, Turku, Finland;Univ Turku, Turku, Finland
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- Ntineri, Angeliki (author)
- Univ Athens, Hypertens Ctr STRIDE 7, Sch Med, Sotiria Hosp,Dept Med 3, Athens, Greece
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- Wei, Fang-Fei (author)
- Univ Leuven, Dept Cardiovasc Sci, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium
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- Kikuya, Masahiro (author)
- Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo, Japan
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- Ohkubo, Takayoshi (author)
- Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo, Japan;Tohoku Inst Management Blood Pressure, Sendai, Miyagi, Japan
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- Dolan, Eamon (author)
- Stroke & Hypertens Unit, Dublin, Ireland
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- Hozawa, Atsushi (author)
- Tohoku Univ, Tohoku Med Megabank Org, Dept Prevent Med & Epidemiol, Sendai, Miyagi, Japan
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- Tsuji, Ichiro (author)
- Tohoku Univ, Dept Publ Hlth, Grad Sch Med, Sendai, Miyagi, Japan
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- Stolarz-Skrzypek, Katarzyna (author)
- Jagiellonian Univ, Dept Cardiol 1, Intervent Electrocardiol & Hypertens, Coll Med, Krakow, Poland
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- Huang, Qi-Fang (author)
- Shanghai Jiao Tong Univ, Sch Med, Ctr Epidemiol Studies, Shanghai, Peoples R China;Shanghai Jiao Tong Univ, Clin Trials & Ctr Vasc Evaluat, Shanghai Inst Hypertens, Shanghai Key Lab Hypertens,Ruijin Hosp, Shanghai, Peoples R China
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- Melgarejo, Jesus D. (author)
- Univ Zulia, Lab Neurociencias, Maracaibo, Venezuela;Univ Zulia, Inst Cardiovasc, Maracaibo, Venezuela
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- Tikhonoff, Valerie (author)
- Univ Padua, Dept Med, Padua, Italy
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- Malyutina, Sofia (author)
- Russian Acad Sci, Inst Internal & Prevent Med Internal & Prevent Me, Inst Cytol & Genet, Siberian Branch, Novosibirsk, Russia
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- Casiglia, Edoardo (author)
- Univ Padua, Dept Med, Padua, Italy
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- Nikitin, Yuri (author)
- Russian Acad Sci, Inst Internal & Prevent Med Internal & Prevent Me, Inst Cytol & Genet, Siberian Branch, Novosibirsk, Russia
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- Lind, Lars (author)
- Uppsala universitet,Geriatrik
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- Sandoya, Edgardo (author)
- Asociac Espanola Primera Socorros Mutuos, Montevideo, Uruguay
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- Aparicio, Lucas (author)
- Univ Buenos Aires, Hosp Italiano Buenos Aires, Dept Med, Buenos Aires, DF, Argentina
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- Barochiner, Jessica (author)
- Univ Buenos Aires, Hosp Italiano Buenos Aires, Dept Med, Buenos Aires, DF, Argentina
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- Gilis-Malinowska, Natasza (author)
- Med Univ Gdansk, Dept Hypertens, Gdansk, Poland
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- Narkiewicz, Krzysztof (author)
- Med Univ Gdansk, Dept Hypertens, Gdansk, Poland
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- Kawecka-Jaszcz, Kalina (author)
- Jagiellonian Univ, Dept Cardiol 1, Intervent Electrocardiol & Hypertens, Coll Med, Krakow, Poland
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- Maestre, Gladys E. (author)
- Univ Zulia, Lab Neurociencias, Maracaibo, Venezuela;Univ Zulia, Inst Cardiovasc, Maracaibo, Venezuela;Univ Texas Rio Grande Valley, Dept Neurosci, Brownsville, TX USA;Univ Texas Rio Grande Valley, Dept Human Genet, Brownsville, TX USA
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- Jula, Antti M. (author)
- Natl Inst Hlth & Welf, Turku, Finland
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- Johansson, Jouni K. (author)
- Natl Inst Hlth & Welf, Turku, Finland
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- Kuznetsova, Tatiana (author)
- Univ Leuven, Dept Cardiovasc Sci, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium
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- Filipovsky, Jan (author)
- Charles Univ Prague, Fac Med, Plzen, Czech Republic
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- Stergiou, George (author)
- Univ Athens, Hypertens Ctr STRIDE 7, Sch Med, Sotiria Hosp,Dept Med 3, Athens, Greece
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- Wang, Ji-Guang (author)
- Shanghai Jiao Tong Univ, Sch Med, Ctr Epidemiol Studies, Shanghai, Peoples R China;Shanghai Jiao Tong Univ, Clin Trials & Ctr Vasc Evaluat, Shanghai Inst Hypertens, Shanghai Key Lab Hypertens,Ruijin Hosp, Shanghai, Peoples R China
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- Imai, Yutaka (author)
- Tohoku Inst Management Blood Pressure, Sendai, Miyagi, Japan
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- O'Brien, Eoin (author)
- Univ Coll Dublin, Conway Inst, Dublin, Ireland
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- Staessen, Jan A. (author)
- Univ Leuven, Dept Cardiovasc Sci, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium;Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2019
- 2019
- English.
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In: Hypertension. - : Lippincott Williams & Wilkins. - 0194-911X .- 1524-4563. ; 74:6, s. 1333-1342
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- Participant-level meta-analyses assessed the age-specific relevance of office blood pressure to cardiovascular complications, but this information is lacking for out-of-office blood pressure. At baseline, daytime ambulatory (n=12 624) or home (n=5297) blood pressure were measured in 17 921 participants (51.3% women; mean age, 54.2 years) from 17 population cohorts. Subsequently, mortality and cardiovascular events were recorded. Using multivariable Cox regression, floating absolute risk was computed across 4 age bands (<= 60, 61-70, 71-80, and >80 years). Over 236 491 person-years, 3855 people died and 2942 cardiovascular events occurred. From levels as low as 110/65 mm Hg, risk log-linearly increased with higher out-of-office systolic/diastolic blood pressure. From the youngest to the oldest age group, rates expressed per 1000 person-years increased (P<0.001) from 4.4 (95% CI, 4.0-4.7) to 86.3 (76.1-96.5) for all-cause mortality and from 4.1 (3.9-4.6) to 59.8 (51.0-68.7) for cardiovascular events, whereas hazard ratios per 20-mm Hg increment in systolic out-of-office blood pressure decreased (P <= 0.0033) from 1.42 (1.19-1.69) to 1.09 (1.05-1.12) and from 1.70 (1.51-1.92) to 1.12 (1.07-1.17), respectively. These age-related trends were similar for out-of-office diastolic pressure and were generally consistent in both sexes and across ethnicities. In conclusion, adverse outcomes were directly associated with out-of-office blood pressure in adults. At young age, the absolute risk associated with out-of-office blood pressure was low, but relative risk high, whereas with advancing age relative risk decreased and absolute risk increased. These observations highlight the need of a lifecourse approach for the management of hypertension.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- blood pressure
- blood pressure monitoring
- ambulatory
- cardiovascular diseases
- hypertension
- mortality
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Li, Yan
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Thijs, Lutgarde
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Zhang, Zhen-Yu
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Asayama, Kei
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Hansen, Tine W.
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Boggia, Jose
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show more...
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Bjoerklund-Bodeg ...
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Yang, Wen-Yi
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Niiranen, Teemu ...
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Ntineri, Angelik ...
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Wei, Fang-Fei
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Kikuya, Masahiro
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Ohkubo, Takayosh ...
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Dolan, Eamon
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Hozawa, Atsushi
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Tsuji, Ichiro
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Stolarz-Skrzypek ...
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Huang, Qi-Fang
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Melgarejo, Jesus ...
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Tikhonoff, Valer ...
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Malyutina, Sofia
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Casiglia, Edoard ...
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Nikitin, Yuri
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Lind, Lars
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Sandoya, Edgardo
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Aparicio, Lucas
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Barochiner, Jess ...
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Gilis-Malinowska ...
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Narkiewicz, Krzy ...
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Kawecka-Jaszcz, ...
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Maestre, Gladys ...
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Jula, Antti M.
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Johansson, Jouni ...
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Kuznetsova, Tati ...
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Filipovsky, Jan
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Stergiou, George
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Wang, Ji-Guang
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Imai, Yutaka
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O'Brien, Eoin
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Staessen, Jan A.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Hypertension
- By the university
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Uppsala University
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Karolinska Institutet