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Revisiting the obes...
Revisiting the obesity paradox in heart failure : Per cent body fat as predictor of biomarkers and outcome
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- Aimo, Alberto (författare)
- Univ Hosp Pisa, Cardiol Div, Pisa, Italy
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- Januzzi, James L., Jr. (författare)
- Massachusetts Gen Hosp, Boston, MA 02114 USA;Baim Inst Clin Res, Boston, MA USA
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- Vergaro, Giuseppe (författare)
- Scuola Super Sant Anna, Inst Life Sci, Pisa, Italy;Fdn Toscana G Monasterio, Pisa, Italy
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- Clerico, Aldo (författare)
- Scuola Super Sant Anna, Inst Life Sci, Pisa, Italy;Fdn Toscana G Monasterio, Pisa, Italy
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- Latini, Roberto (författare)
- IRCCS, Dept Cardiovasc Res, Ist Ric Farmacolog Mario Negri, Milan, Italy
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- Meessen, Jennifer (författare)
- IRCCS, Dept Cardiovasc Res, Ist Ric Farmacolog Mario Negri, Milan, Italy
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- Anand, Inder S. (författare)
- Univ Minnesota, Div Cardiovasc Med, Minneapolis, MN USA;VA Med Ctr, Dept Cardiol, Minneapolis, MN USA
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- Cohn, Jay N. (författare)
- Univ Minnesota, Div Cardiovasc Med, Minneapolis, MN USA
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- Gravning, Jorgen (författare)
- Oslo Univ Hosp, Dept Cardiol, Oslo, Norway;Univ Oslo, Ctr Heart Failure Res, Oslo, Norway
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- Ueland, Thor (författare)
- Oslo Univ Hosp, Rikshosp, Res Inst Internal Med, Oslo, Norway;Univ Oslo, Fac Med, Oslo, Norway;Univ Tromso, KG Jebsen Thrombosis Res & Expertise Ctr, Tromso, Norway
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- Nymo, Stale H. (författare)
- Oslo Univ Hosp, Rikshosp, Res Inst Internal Med, Oslo, Norway
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- Brunner-La Rocca, Hans-Peter (författare)
- Maastricht Univ, Dept Cardiol, Med Ctr, Maastricht, Netherlands
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- Bayes-Genis, Antoni (författare)
- Hosp Badalona Germans Trias & Pujol, Badalona, Barcelona, Spain
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- Lupon, Josep (författare)
- Hosp Badalona Germans Trias & Pujol, Badalona, Barcelona, Spain
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- de Boer, Rudolf A. (författare)
- Univ Med Ctr Groningen, Groningen, Netherlands
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- Yoshihisa, Akiomi (författare)
- Fukushima Med Univ, Dept Cardiovasc Med, Fukushima, Japan
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- Takeishi, Yasuchika (författare)
- Fukushima Med Univ, Dept Cardiovasc Med, Fukushima, Japan
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- Egstrup, Michael (författare)
- Copenhagen Univ Hosp, Dept Cardiol, Rigshosp, Copenhagen, Denmark
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- Gustafsson, Ida (författare)
- Copenhagen Univ Hosp, Dept Cardiol, Rigshosp, Copenhagen, Denmark
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- Gagging, Hanna K. (författare)
- Massachusetts Gen Hosp, Boston, MA 02114 USA;Baim Inst Clin Res, Boston, MA USA
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- Eggers, Kai M., 1962- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Huber, Kurt (författare)
- Wilhelminenspital & Sigmund Freud Univ, Fac Internal Med, Med Sch, Vienna, Austria
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- Tentzeris, Ioannis (författare)
- Wilhelminenspital & Sigmund Freud Univ, Fac Internal Med, Med Sch, Vienna, Austria
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- Ripoli, Andrea (författare)
- Fdn Toscana G Monasterio, Pisa, Italy
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- Passino, Claudio (författare)
- Scuola Super Sant Anna, Inst Life Sci, Pisa, Italy;Fdn Toscana G Monasterio, Pisa, Italy
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- Emdin, Michele (författare)
- Scuola Super Sant Anna, Inst Life Sci, Pisa, Italy;Fdn Toscana G Monasterio, Pisa, Italy
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(creator_code:org_t)
- 2019-06-01
- 2019
- Engelska.
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Ingår i: European Journal of Preventive Cardiology. - : Sage Publications. - 2047-4873 .- 2047-4881. ; 26:16, s. 1751-1759
- Relaterad länk:
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https://munin.uit.no...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims Obesity defined by body mass index (BMI) is characterized by better prognosis and lower plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure. We assessed whether another anthropometric measure, per cent body fat (PBF), reveals different associations with outcome and heart failure biomarkers (NT-proBNP, high-sensitivity troponin T (hs-TnT), soluble suppression of tumorigenesis-2 (sST2)). Methods In an individual patient dataset, BMI was calculated as weight (kg)/height (m) (2) , and PBF through the Jackson-Pollock and Gallagher equations. Results Out of 6468 patients (median 68 years, 78% men, 76% ischaemic heart failure, 90% reduced ejection fraction), 24% died over 2.2 years (1.5-2.9), 17% from cardiovascular death. Median PBF was 26.9% (22.4-33.0%) with the Jackson-Pollock equation, and 28.0% (23.8-33.5%) with the Gallagher equation, with an extremely strong correlation (r = 0.996, p < 0.001). Patients in the first PBF tertile had the worst prognosis, while patients in the second and third tertile had similar survival. The risks of all-cause and cardiovascular death decreased by up to 36% and 27%, respectively, per each doubling of PBF. Furthermore, prognosis was better in the second or third PBF tertiles than in the first tertile regardless of model variables. Both BMI and PBF were inverse predictors of NT-proBNP, but not hs-TnT. In obese patients (BMI >= 30 kg/m(2), third PBF tertile), hs-TnT and sST2, but not NT-proBNP, independently predicted outcome. Conclusion In parallel with increasing BMI or PBF there is an improvement in patient prognosis and a decrease in NT-proBNP, but not hs-TnT or sST2. hs-TnT or sST2 are stronger predictors of outcome than NT-proBNP among obese patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Obesity
- heart failure
- natriuretic peptides
- troponin
- sST2
- prognosis
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- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Aimo, Alberto
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Januzzi, James L ...
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Vergaro, Giusepp ...
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Clerico, Aldo
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Latini, Roberto
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Meessen, Jennife ...
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visa fler...
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Anand, Inder S.
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Cohn, Jay N.
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Gravning, Jorgen
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Ueland, Thor
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Nymo, Stale H.
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Brunner-La Rocca ...
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Bayes-Genis, Ant ...
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Lupon, Josep
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de Boer, Rudolf ...
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Yoshihisa, Akiom ...
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Takeishi, Yasuch ...
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Egstrup, Michael
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Gustafsson, Ida
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Gagging, Hanna K ...
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Eggers, Kai M., ...
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Huber, Kurt
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Tentzeris, Ioann ...
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Ripoli, Andrea
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Passino, Claudio
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Emdin, Michele
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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European Journal ...
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