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Kankanet :
Kankanet : An artificial neural network-based object detection smartphone application and mobile microscope as a point-of-care diagnostic aid for soil-transmitted helminthiases
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- Yang, Ariel (författare)
- SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USA;SUNY Stony Brook, Global Hlth Inst, Stony Brook, NY 11794 USA
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- Bakhtari, Nahid (författare)
- SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USA;SUNY Stony Brook, Global Hlth Inst, Stony Brook, NY 11794 USA
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- Langdon-Embry, Liana (författare)
- SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USA;SUNY Stony Brook, Global Hlth Inst, Stony Brook, NY 11794 USA
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- Redwood, Emile (författare)
- SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USA;SUNY Stony Brook, Global Hlth Inst, Stony Brook, NY 11794 USA
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- Lapierre, Simon Grandjean (författare)
- SUNY Stony Brook, Global Hlth Inst, Stony Brook, NY 11794 USA;Ctr Hosp Univ Montreal, Ctr Rech, Immunopathol Axis, Montreal, PQ, Canada;Inst Pasteur Madagascar, Mycobacteria Unit, Antananarivo, Madagascar
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- Rakotomanga, Patricia (författare)
- Inst Pasteur Madagascar, Helminthiasis Unit, Antananarivo, Madagascar
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- Rafalimanantsoa, Armand (författare)
- Inst Pasteur Madagascar, Helminthiasis Unit, Antananarivo, Madagascar
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- De Dios Santos, Juan (författare)
- Uppsala universitet,Institutionen för informationsteknologi
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- Vigan-Womas, Ines (författare)
- Inst Pasteur Madagascar, Immunol Infect Dis Unit, Antananarivo, Madagascar
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- Knoblauch, Astrid M. (författare)
- SUNY Stony Brook, Global Hlth Inst, Stony Brook, NY 11794 USA;Inst Pasteur Madagascar, Mycobacteria Unit, Antananarivo, Madagascar;Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland
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- Marcos, Luis A. (författare)
- SUNY Stony Brook, Global Hlth Inst, Stony Brook, NY 11794 USA;SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA
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(creator_code:org_t)
- 2019-08-05
- 2019
- Engelska.
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Ingår i: PLoS Neglected Tropical Diseases. - : Public Library of Science (PLoS). - 1935-2727 .- 1935-2735. ; 13:8
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundEndemic areas for soil-transmitted helminthiases often lack the tools and trained personnel necessary for point-of-care diagnosis. This study pilots the use of smartphone microscopy and an artificial neural network-based (ANN) object detection application named Kankanet to address those two needs.Methodology/Principal findingsA smartphone was equipped with a USB Video Class (UVC) microscope attachment and Kankanet, which was trained to recognize eggs of Ascaris lumbricoides, Trichuris trichiura, and hookworm using a dataset of 2,078 images. It was evaluated for interpretive accuracy based on 185 new images. Fecal samples were processed using Kato-Katz (KK), spontaneous sedimentation technique in tube (SSTT), and Merthiolate-Iodine-Formaldehyde (MIF) techniques. UVC imaging and ANN interpretation of these slides was compared to parasitologist interpretation of standard microscopy.Relative to a gold standard defined as any positive result from parasitologist reading of KK, SSTT, and MIF preparations through standard microscopy, parasitologists reading UVC imaging of SSTT achieved a comparable sensitivity (82.9%) and specificity (97.1%) in A. lumbricoides to standard KK interpretation (97.0% sensitivity, 96.0% specificity). The UVC could not accurately image T. trichiura or hookworm. Though Kankanet interpretation was not quite as sensitive as parasitologist interpretation, it still achieved high sensitivity for A. lumbricoides and hookworm (69.6% and 71.4%, respectively). Kankanet showed high sensitivity for T. trichiura in microscope images (100.0%), but low in UVC images (50.0%).Conclusions/SignificanceThe UVC achieved comparable sensitivity to standard microscopy with only A. lumbricoides. With further improvement of image resolution and magnification, UVC shows promise as a point-of-care imaging tool. In addition to smartphone microscopy, ANN-based object detection can be developed as a diagnostic aid. Though trained with a limited dataset, Kankanet accurately interprets both standard microscope and low-quality UVC images. Kankanet may achieve sensitivity comparable to parasitologists with continued expansion of the image database and improvement of machine learning technology.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
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- Av författaren/redakt...
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Yang, Ariel
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Bakhtari, Nahid
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Langdon-Embry, L ...
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Redwood, Emile
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Lapierre, Simon ...
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Rakotomanga, Pat ...
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Rafalimanantsoa, ...
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De Dios Santos, ...
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Vigan-Womas, Ine ...
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Knoblauch, Astri ...
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Marcos, Luis A.
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Geovetenskap och ...
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och Miljövetenskap
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Mikrobiologi ino ...
- Artiklar i publikationen
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PLoS Neglected T ...
- Av lärosätet
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Uppsala universitet