Search: L773:1613 4125
> (2015-2019) >
High-Fat Diet Enric...
High-Fat Diet Enriched with Bilberry Modifies Colonic Mucus Dynamics and Restores Marked Alterations of Gut Microbiome in Rats
-
- Liu, Haoyu (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
-
- Waldén, Tomas, 1978- (author)
- Uppsala University,Uppsala universitet,Institutionen för medicinsk cellbiologi
-
- Ahl, David (author)
- Uppsala University,Uppsala universitet,Institutionen för medicinsk cellbiologi
-
show more...
-
- Nyman, Margareta (author)
- Lund University,Lunds universitet,Avdelningen för livsmedel och läkemedel,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Food and Pharma,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH
-
- Bertilsson, Stefan (author)
- Uppsala University,Uppsala universitet,Limnologi,Science for Life Laboratory, SciLifeLab
-
- Phillipson, Mia, 1973- (author)
- Uppsala University,Uppsala universitet,Institutionen för medicinsk cellbiologi
-
- Holm, Lena (author)
- Uppsala University,Uppsala universitet,Institutionen för medicinsk cellbiologi
-
- Liu, Hao Yu (author)
- Uppsala University
-
show less...
-
(creator_code:org_t)
- 2019-08-12
- 2019
- English.
-
In: Molecular Nutrition & Food Research. - : WILEY. - 1613-4125 .- 1613-4133. ; 63:20
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
show less...
Abstract
Subject headings
Close
- Scope Emerging evidence suggests that high-fat diet (HFD) is associated with gut microbiome dysbiosis and related disorders. Bilberry is a prebiotic food component with known health benefits. Herein, the dynamics of the colonic mucus layer and microbiome during HFD and bilberry supplementation are addressed. Methods and results The effects on colonic mucus thickness in vivo and gut microbiota composition (Illumina sequencing, quantitative real-time PCR) are investigated in young rats fed a low-fat diet or HFD with or without bilberries for 8 weeks (n = 8). HFD induced significant local colonic effects, despite no observed weight gain or systemic inflammation, as HFD causes epithelial upregulation of inducible nitric oxide synthase, which is counteracted by bilberry. The firmly adherent mucus layer becomes thicker and the mRNA levels of Muc2 and Tff3 are increased by HFD with or without bilberry. In parallel, HFD reduced the colonic abundance of mucolytic bacterial species Akkermansia muciniphila and Bacteroides spp. Finally, bilberry prevents HFD-induced microbiota dysbiosis, including expansion of pathobionts, for example, Enterobacteriaceae. Conclusion HFD expand firmly adherent mucus thickness and reduce mucus-foraging bacteria populations in the colon prior to obesity. Enriching HFD with bilberry protects against intestinal inflammation and marked microbiota encroachment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Akkermansia muciniphila
- bilberries
- gut microbiome
- high-fat diet
- mucus
- Akkermansia muciniphila
- bilberries
- gut microbiome
- high-fat diet
- mucus
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Liu, Haoyu
-
Waldén, Tomas, 1 ...
-
Ahl, David
-
Nyman, Margareta
-
Bertilsson, Stef ...
-
Phillipson, Mia, ...
-
show more...
-
Holm, Lena
-
Liu, Hao Yu
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nutrition and Di ...
- Articles in the publication
-
Molecular Nutrit ...
- By the university
-
Uppsala University
-
Lund University