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Effects of a nutrit...
Effects of a nutrition intervention on acute and late bowel symptoms and health-related quality of life up to 24 months post radiotherapy in patients with prostate cancer : a multicentre randomised controlled trial.
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- Forslund, Marina (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Birgitta Johansson
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- Ottenblad, Anna (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Karolinska Univ Hosp, Dept Nutr & Dietet, Stockholm, Sweden
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- Ginman, Claes (författare)
- Cent Hosp Karlstad, Dept Clin Oncol, Karlstad, Sweden
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- Johansson, Silvia (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Nygren, Peter (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Johansson, Birgitta, 1959- (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Birgitta Johansson
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(creator_code:org_t)
- 2019-11-22
- 2020
- Engelska.
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Ingår i: Supportive Care in Cancer. - : Springer Nature. - 0941-4355 .- 1433-7339. ; 28:7, s. 3331-3342
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose: Radiotherapy to the prostate gland and pelvic lymph nodes may cause acute and late bowel symptoms and diminish quality of life. The aim was to study the effects of a nutrition intervention on bowel symptoms and health-related quality of life, compared with standard care.Methods: Patients were randomised to a nutrition intervention (n = 92) aiming to replace insoluble fibres with soluble and reduce intake of lactose, or a standard care group (n = 88) who were recommended to maintain their habitual diet. Bowel symptoms, health-related quality of life and intake of fibre and lactose-containing foods were assessed up to 24 months after radiotherapy completion. Multiple linear regression was used to analyse the effects of the nutrition intervention on bowel symptoms during the acute (up to 2 months post radiotherapy) and the late (7 to 24 months post radiotherapy) phase.Results: Most symptoms and functioning worsened during the acute phase, and improved during the late phase in both the intervention and standard care groups. The nutrition intervention was associated with less blood in stools (p = 0.047), flatulence (p = 0.014) and increased loss of appetite (p = 0.018) during the acute phase, and more bloated abdomen in the late phase (p = 0.029). However, these associations were clinically trivial or small.Conclusions: The effect of the nutrition intervention related to dietary fibre and lactose on bowel symptoms from pelvic RT was small and inconclusive, although some minor and transient improvements were observed. The results do not support routine nutrition intervention of this type to reduce adverse effects from pelvic radiotherapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
Nyckelord
- Nutrition intervention
- Radiotherapy
- Bowel symptoms
- Prostate cancer
- Caring Sciences
- Vårdvetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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