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  • Botling, JohanUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi (author)

High-grade progression confers poor survival in pancreatic neuroendocrine tumors

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2019-10-29
  • S. Karger AG,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-399943
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-399943URI
  • https://doi.org/10.1159/000504392DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • INTRODUCTION: Little is known about how Pancreatic Neuroendocrine Tumors (PanNETs) evolve over time and if changes towards a more aggressive biology correlates with prognosis. The purpose of this study was to characterize changes PanNET differentiation and proliferation over time, and to correlate findings to overall survival (OS).PATIENTS AND METHODS: In this retrospective cohort study we screened 475 PanNET patients treated at Uppsala University Hospital, Sweden. Sporadic patients with baseline and follow-up tumor samples were included. Pathology reports and available tissue sections were re-evaluated with regard to tumor histopathology and Ki-67 index.RESULTS: Forty-six patients with 106 tumor samples (56 available for pathology re-evaluation) were included. Median Ki-67 index at diagnosis was 7% (range 1-38%), grade 1 n=8, grade 2 n=36, and grade 3 n=2. The median change in Ki-67 index (absolute value; follow-up - baseline) was +14% (range -11 to +80%). Increase in tumor grade occurred in 28 patients (63.6%), the majority from grade 1/2 to grade 3 (n=24, 54.5%). The patients with a high-grade progression had a median OS of 50.2 months compared to 115.1 months in patients without such progression (HR 3.89, 95% CI 1.91-7.94, P<0.001).CONCLUSIONS: A longitudinal increase in Ki-67 index and increase in tumor grade were observed in a majority of PanNETs included in this study. We propose that increase in Ki-67 index and high-grade progression should be investigated further as important biomarkers in PanNET.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lamarca, Angela (author)
  • Bajic, DuskaUppsala universitet,Endokrin tumörbiologi(Swepub:uu)dusba300 (author)
  • Norlén, OlovUppsala universitet,Endokrinkirurgi(Swepub:uu)olono376 (author)
  • Lönngren, Vincent,1977-Uppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)vinlo174 (author)
  • Kjaer, JosefinUppsala universitet,Endokrinkirurgi(Swepub:uu)joskj191 (author)
  • Eriksson, BarbroUppsala universitet,Endokrin tumörbiologi(Swepub:uu)barberik (author)
  • Welin, StaffanUppsala universitet,Onkologisk endokrinologi(Swepub:uu)stafweli (author)
  • Hellman, PerUppsala universitet,Endokrinkirurgi,Experimentell kirurgi(Swepub:uu)perhellm (author)
  • Rindi, Guido (author)
  • Skogseid, BrittUppsala universitet,Endokrin tumörbiologi(Swepub:uu)brittsko (author)
  • Crona, JoakimUppsala universitet,Endokrin tumörbiologi(Swepub:uu)joacr310 (author)
  • Uppsala universitetScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Related titles

  • In:Neuroendocrinology: S. Karger AG110:11-12, s. 891-8980028-38351423-0194

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