International prognostic scoring system for mastocytosis (IPSM): a retrospective cohort study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: (WFRF:(Brockow Knut)) > International progn...

International prognostic scoring system for mastocytosis (IPSM) : a retrospective cohort study

Sperr, Wolfgang R. (författare): Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, A-1090 Vienna, Austria;Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, A-1090 Vienna, Austria

Kundi, Michael (författare): Med Univ Vienna, Inst Environm Hlth, Vienna, Austria

Alvarez-Twose, Ivan (författare): Hosp Virgen Valle, Inst Estudios Mastocitosis Castilla Mancha CLMast, Toledo, Spain

visa fler...

van Anrooij, Bjorn (författare): Univ Groningen, Univ Med Ctr Groningen, Dept Hematol, Groningen, Netherlands;Univ Groningen, Univ Med Ctr Groningen, Dept Allergol, Groningen, Netherlands

Elberink, Joanna N. G. Oude (författare): Univ Groningen, Univ Med Ctr Groningen, Dept Allergol, Groningen, Netherlands

Gorska, Aleksandra (författare): Med Univ Gdansk, Dept Allergol, Gdansk, Poland

Niedoszytko, Marek (författare): Med Univ Gdansk, Dept Allergol, Gdansk, Poland

Gleixner, Karoline V. (författare): Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, A-1090 Vienna, Austria;Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, A-1090 Vienna, Austria

Hadzijusufovic, Emir (författare): Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, A-1090 Vienna, Austria;Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, A-1090 Vienna, Austria;Univ Vet Med, Dept Univ Clin Compan Anim & Horses, Univ Clin Small Anim, Internal Med Small Anim, Vienna, Austria

Zanotti, Roberta (författare): Verona Univ Hosp, Sect Hematol, Dept Med, Verona, Italy

Bonadonna, Patrizia (författare): Verona Univ Hosp, Allergy Unit, Verona, Italy

Bonifacio, Massimiliano (författare): Verona Univ Hosp, Sect Hematol, Dept Med, Verona, Italy

Perkins, Cecelia (författare): Stanford Univ, Sch Med, Dept Med, Div Hematol, Stanford, CA 94305 USA

Illerhaus, Anja (författare): Univ Cologne, Dept Dermatol, Cologne, Germany

Elena, Chiara (författare): Univ Pavia, Dept Mol Med, Pavia, Italy;Univ Pavia, Dept Hematol Oncol, Pavia, Italy;Fdn IRCCS Policlin San Matteo, Pavia, Italy

Merante, Serena (författare): Univ Pavia, Dept Mol Med, Pavia, Italy;Univ Pavia, Dept Hematol Oncol, Pavia, Italy;Fdn IRCCS Policlin San Matteo, Pavia, Italy

Shoumariyeh, Khalid (författare): Univ Freiburg, Fac Med, Med Ctr, Dept Hematol Oncol & Stem Cell Transplantat, Freiburg, Germany

von Bubnoff, Nikolas (författare): Univ Freiburg, Fac Med, Med Ctr, Dept Hematol Oncol & Stem Cell Transplantat, Freiburg, Germany;Univ Schleswig Holstein, Med Ctr, Dept Hematol & Oncol, Campus Lubeck, Lubeck, Germany

Parente, Roberta (författare): Univ Salerno, Div Allergy & Clin Immunol, Salerno, Italy

Jawhar, Mohamad (författare): Heidelberg Univ, Univ Med Mannheim, Med Klin 3, Mannheim, Germany

Fortina, Anna Belloni (författare): Univ Padua, Dept Med, Pediat Dermatol Unit, Padua, Italy

Caroppo, Francesca (författare): Univ Padua, Dept Med, Pediat Dermatol Unit, Padua, Italy

Brockow, Knut (författare): Tech Univ Munich, Sch Med, Dept Dermatol & Allergy, Munich, Germany

Zink, Alexander (författare): Tech Univ Munich, Sch Med, Dept Dermatol & Allergy, Munich, Germany

Fuchs, David (författare): Johannes Kepler Univ Linz, Kepler Univ Hosp, Univ Clin Hematol & Internal Oncol, Linz, Austria

Kilbertus, Alex J. (författare): Johannes Kepler Univ Linz, Kepler Univ Hosp, Dept Dermatol & Venerol, Linz, Austria

Yavuz, Akif Selim (författare): Istanbul Univ, Istanbul Med Sch, Div Hematol, Istanbul, Turkey

Doubek, Michael (författare): Masaryk Univ, Univ Hosp, Brno, Czech Republic;Masaryk Univ, CEITEC, Brno, Czech Republic

Hägglund, Hans (författare): Uppsala universitet,Hematologi

Panse, Jens (författare): Dept Oncol, Haematol, Aachen, Germany

Sabato, Vito (författare): Univ Antwerp, Dept Immunol Allergol Rheumatol, Fac Med & Hlth Sci, Antwerp, Belgium;Antwerp Univ Hosp, Antwerp, Belgium

Bretterklieber, Agnes (författare): Univ Hosp Graz, Dept Dermatol & Venereol, Graz, Austria

Niederwieser, Dietger (författare): Univ Hosp Leipzig, Leipzig, Germany

Breynaert, Christine (författare): Univ Hosp Leuven, KU Leuven, Dept Microbiol Immunol & Transplantat, Allergy & Clin Immunol Res Grp, Leuven, Belgium;Univ Hosp Leuven, MASTeL, Leuven, Belgium

Hartmann, Karin (författare): Univ Cologne, Dept Dermatol, Cologne, Germany;Univ Basel, Div Allergy, Dept Dermatol, Basel, Switzerland;Univ Basel, Dept Biomed, Basel, Switzerland

Triggiani, Massimo (författare): Univ Salerno, Div Allergy & Clin Immunol, Salerno, Italy

Nedoszytko, Boguslaw (författare): Med Univ Gdansk, Dept Dermatol, Gdansk, Poland

Reiter, Andreas (författare): Heidelberg Univ, Univ Med Mannheim, Med Klin 3, Mannheim, Germany

Orfao, Alberto (författare): Univ Salamanca, Ctr Invest Canc, CSIC, IBMCC,USAL,CIBERONC, Salamanca, Spain;Univ Salamanca, Dept Med, IBSAL, Salamanca, Spain;Univ Salamanca, Serv Gen Citometria, Salamanca, Spain

Hermine, Olivier (författare): Univ Paris 05, Imagine Inst, Ctr Natl Reference Mastocytoses, Sorbonne Paris Cite, Paris, France

Gotlib, Jason (författare): Stanford Univ, Sch Med, Dept Med, Div Hematol, Stanford, CA 94305 USA

Arock, Michel (författare): Paris Sorbonne Univ, Pitie Salpetriere Hosp, Dept Hematol Biol, UMR8113, Paris, France

Kluin-Nelemans, Hanneke C. (författare): Univ Groningen, Univ Med Ctr Groningen, Dept Hematol, Groningen, Netherlands

Valent, Peter (författare)

visa färre...

(creator_code:org_t)

ELSEVIER SCI LTD, 2019
2019
Engelska.
Ingår i: The Lancet Haematology. - : ELSEVIER SCI LTD. - 2352-3026. ; 6:12, s. E638-E649

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Background The WHO classification separates mastocytosis into distinct variants, but prognostication remains a clinical challenge. The aim of this study was to improve prognostication for patients with mastocytosis. Methods We analysed data of the registry of the European Competence Network on Mastocytosis including 1639 patients (age 17-90 years) diagnosed with mastocytosis according to WHO criteria between Jan 12, 1978, and March 16, 2017. Univariate and multivariate analyses with Cox regression were applied to identify prognostic variables predicting survival outcomes and to establish a prognostic score. We validated this International Prognostic Scoring System in Mastocytosis (IPSM) with data of 462 patients (age 17-79 years) from the Spanish network Red Espanola de Mastocitosis diagnosed between Jan 22, 1998, and Nov 2, 2017. Findings The prognostic value of the WHO classification was confirmed in our study (p<0.0001). For patients with non-advanced mastocytosis (n=1380), we identified age 60 years or older (HR 10.75, 95% CI 5.68-20.32) and a concentration of alkaline phosphatase 100 U/L or higher (2.91, 1.60-5.30) as additional independent prognostic variables for overall survival. The resulting scoring system divided patients with non-advanced mastocytosis into three groups: low (no risk factors), intermediate 1 (one risk factor), and intermediate 2 (two risk factors). Overall survival and progression-free survival differed significantly among these groups (p<0.0001). In patients with advanced mastocytosis (n=259), age 60 years or older (HR 2.14, 95% CI 1.42-3.22), a concentration of tryptase 125 ng/mL or higher (1.81, 1.20-2.75), a leukocyte count of 16 x 10(9) per L or higher (1.88, 1.27-2.79), haemoglobin of 11 g/dL or lower (1.71, 1.13-2.57), a platelet count of 100 x 10(9) per L or lower (1.63, 1.13-2.34), and skin involvement (0.46, 0.30-0.69) were prognostic variables. Based on these variables, a separate score for advanced mastocytosis with four risk categories was established, with significantly different outcomes for overall survival and progression-free survival (p<0.0001). The prognostic value of both scores was confirmed in 413 patients with non-advanced disease and 49 with advanced mastocytosis from the validation cohort. Interpretation The IPSM scores for patients with non-advanced and advanced mastocytosis can be used to predict survival outcomes and guide treatment decisions. However, the predictive value of the IPSM needs to be confirmed in forthcoming trials. Copyright (C) 2019 Elsevier Ltd. All rights reserved.

Hitta via bibliotek

The Lancet Haematology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Sperr, Wolfgang ...; Kundi, Michael; Alvarez-Twose, I ...; van Anrooij, Bjo ...; Elberink, Joanna ...; Gorska, Aleksand ...; visa fler...; Niedoszytko, Mar ...; Gleixner, Karoli ...; Hadzijusufovic, ...; Zanotti, Roberta; Bonadonna, Patri ...; Bonifacio, Massi ...; Perkins, Cecelia; Illerhaus, Anja; Elena, Chiara; Merante, Serena; Shoumariyeh, Kha ...; von Bubnoff, Nik ...; Parente, Roberta; Jawhar, Mohamad; Fortina, Anna Be ...; Caroppo, Frances ...; Brockow, Knut; Zink, Alexander; Fuchs, David; Kilbertus, Alex ...; Yavuz, Akif Seli ...; Doubek, Michael; Hägglund, Hans; Panse, Jens; Sabato, Vito; Bretterklieber, ...; Niederwieser, Di ...; Breynaert, Chris ...; Hartmann, Karin; Triggiani, Massi ...; Nedoszytko, Bogu ...; Reiter, Andreas; Orfao, Alberto; Hermine, Olivier; Gotlib, Jason; Arock, Michel; Kluin-Nelemans, ...; Valent, Peter; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Hematologi

Artiklar i publikationen: The Lancet Haema ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

International prognostic scoring system for mastocytosis (IPSM) : a retrospective cohort study

Ämnesord

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub