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Emotional Mental Im...
Emotional Mental Imagery Abnormalities in Monozygotic Twins With, at High-Risk of, and Without Affective Disorders : Present in Affected Twins in Remission but Absent in High-Risk Twins
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- Di Simplicio, Martina (författare)
- Imperial Coll London, Dept Brain Sci, Div Psychiat, London, England
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- Lau-Zhu, Alex (författare)
- Imperial Coll London, Dept Brain Sci, Div Psychiat, London, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England;Univ Oxford, Oxford Inst Clin Psychol Training, Med Sci Div, Oxford, England
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- Meluken, Iselin (författare)
- Copenhagen Univ Hosp, Rigshosp, Psychiat Ctr Copenhagen, Copenhagen Affect Disorder Res Ctr CADIC, Copenhagen, Denmark
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- Taylor, Patrick (författare)
- Imperial Coll London, Dept Brain Sci, Div Psychiat, London, England
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- Kessing, Lars Vedel (författare)
- Copenhagen Univ Hosp, Rigshosp, Psychiat Ctr Copenhagen, Copenhagen Affect Disorder Res Ctr CADIC, Copenhagen, Denmark
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- Vinberg, Maj (författare)
- Copenhagen Univ Hosp, Rigshosp, Psychiat Ctr Copenhagen, Copenhagen Affect Disorder Res Ctr CADIC, Copenhagen, Denmark
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- Holmes, Emily Alexandra (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Clin Neurosci, Div Psychol, Stockholm, Sweden
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- Miskowiak, Kamilla Woznica (författare)
- Copenhagen Univ Hosp, Rigshosp, Psychiat Ctr Copenhagen, Copenhagen Affect Disorder Res Ctr CADIC, Copenhagen, Denmark;Univ Copenhagen, Dept Psychol, Copenhagen, Denmark
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(creator_code:org_t)
- 2019-11-08
- 2019
- Engelska.
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Ingår i: Frontiers in Psychiatry. - : Frontiers Media S.A.. - 1664-0640. ; 10
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Abstract
Ämnesord
Stäng
- Background: Mental imagery abnormalities feature across affective disorders including bipolar disorder (BD) and unipolar depression (UD). Maladaptive emotional imagery has been proposed as a maintenance factor for affective symptomatology and a target for mechanism-driven psychological treatment developments. Where imagery abnormalities feature beyond acute affective episodes, further opportunities for innovation arise beyond treatments, such as for tertiary/relapse prevention (e.g., in remitted individuals) or primary prevention (e.g., in non-affected but at-risk individuals). The aim of our study was to investigate for the first time the presence of possible mental imagery abnormalities in affected individuals in remission and at-risk individuals for affective disorders using a familial risk design. Methods: A population-based cohort of monozygotic twins was recruited through linkage between the Danish national registries (N=204). Participants were grouped as: affected (remitted BD/UD; n = 115); high-risk (co-twin with history of BD/UD; n = 49), or low-risk (no co-twin history of BD/UD; n = 40). Twins completed mental imagery measures spanning key subjective domains (spontaneous imagery use and emotional imagery) and cognitive domains (imagery inspection and imagery manipulation). Results: Affected twins in remission reported enhanced emotional mental imagery compared to both low- and high-risk twins. This was characterized by greater impact of i) intrusive prospective imagery (Impact of Future Events Scale) and ii) deliberately-generated prospective imagery of negative scenarios (Prospective Imagery Task). There were no significant differences in these key measures between affected BD and UD twins in remission. Additionally, low- and high-risk twins did not significantly differ on these emotional imagery measures. There were also no significant differences between the three groups on non-emotional measures including spontaneous imagery use and cognitive stages of imagery. Conclusions: Abnormalities in emotional prospective imagery are present in monozygotic twins with affective disorders in remission-despite preserved cognitive stages of imagery-but absent in unaffected high-risk twins, and thus do not appear to index familial risk (i.e., unlikely to qualify as "endophenotypes"). Elevated emotional prospective imagery represents a promising treatment/prevention target in affective disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- mental imagery
- future simulation
- bipolar disorder
- depression
- twins
- endophenotype
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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