High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: (WFRF:(Syvänen Ann Christine 1950 )) > High genetic risk s...

High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus

Reid, Sarah (författare): Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab

Alexsson, Andrei (författare): Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab

Frodlund, Martina (författare): Linköping University,Rheumatology/Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linkoping, Sweden

visa fler...

Morris, David (författare): Department of Medical and Molecular Genetics, King’s College London, London, UK

Sandling, Johanna K. (författare): Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab

Bolin, Karin (författare): Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab

Svenungsson, Elisabet (författare): Karolinska Institutet,Karolinska Institute,Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Jönsen, Andreas (författare): Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Rheumatology, Department of Clinical Sciences, Lund University, Lund, Sweden

Bengtsson, Christine (författare): Umeå University,Umeå universitet,Reumatologi,Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden

Gunnarsson, Iva (författare): Karolinska Institutet,Karolinska Institute,Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Illescas Rodriguez, Vera (författare): Karolinska Institute,Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Bengtsson, Anders (författare): Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Rheumatology, Department of Clinical Sciences, Lund University, Lund, Sweden

Arve, Sabine (författare): Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Rheumatology, Department of Clinical Sciences, Lund University, Lund, Sweden

Rantapää-Dahlqvist, Solbritt (författare): Umeå University,Umeå universitet,Reumatologi,Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden

Eloranta, Maija-Leena (författare): Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab

Syvänen, Ann-Christine, 1950- (författare): Uppsala University,Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab

Sjöwall, Christopher (författare): Linköping University,Rheumatology/Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linkoping, Sweden

Vyse, Timothy James (författare): Department of Medical and Molecular Genetics, King’s College London, London, UK

Rönnblom, Lars (författare): Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab

Leonard, Dag, 1975- (författare): Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab

visa färre...

(creator_code:org_t)

2019-12-11
2020
Engelska.
Ingår i: Annals of the Rheumatic Diseases. - : BMJ Publishing Group Ltd. - 0003-4967 .- 1468-2060. ; 79:3, s. 363-369

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://ard.bmj.com/...; https://umu.diva-por... (primary) (Raw object); http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; https://lup.lub.lu.s...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

OBJECTIVES: To investigate associations between a high genetic disease risk and disease severity in patients with systemic lupus erythematosus (SLE).METHODS: Patients with SLE (n=1001, discovery cohort and n=5524, replication cohort) and healthy controls (n=2802 and n=9859) were genotyped using a 200K Immunochip single nucleotide polymorphism array. A genetic risk score (GRS) was assigned to each individual based on 57 SLE risk loci.RESULTS: SLE was more prevalent in the high, compared with the low, GRS-quartile (OR 12.32 (9.53 to 15.71), p=7.9×10-86 and OR 7.48 (6.73 to 8.32), p=2.2×10-304 for the discovery and the replication cohorts, respectively). In the discovery cohort, patients in the high GRS-quartile had a 6-year earlier mean disease onset (HR 1.47 (1.22 to 1.75), p=4.3×10-5), displayed higher prevalence of damage accrual (OR 1.47 (1.06 to 2.04), p=2.0×10-2), renal disorder (OR 2.22 (1.50 to 3.27), p=5.9×10-5), anti-dsDNA (OR 1.83 (1.19 to 2.81), p=6.1×10-3), end-stage renal disease (ESRD) (OR 5.58 (1.50 to 20.79), p=1.0×10-2), proliferative nephritis (OR 2.42 (1.30 to 4.49), p=5.1×10-3), anti-cardiolipin-IgG (OR 1.89 (1.13 to 3.18), p=1.6×10-2), anti-β2-glycoprotein-I-IgG (OR 2.29 (1.29 to 4.06), p=4.8×10-3) and positive lupus anticoagulant test (OR 2.12 (1.16 to 3.89), p=1.5×10-2) compared with patients in the low GRS-quartile. Survival analysis showed earlier onset of the first organ damage (HR 1.51 (1.04 to 2.25), p=3.7×10-2), first cardiovascular event (HR 1.65 (1.03 to 2.64), p=2.6×10-2), nephritis (HR 2.53 (1.72 to 3.71), p=9.6×10-7), ESRD (HR 6.78 (1.78 to 26.86), p=6.5×10-3) and decreased overall survival (HR 1.83 (1.02 to 3.30), p=4.3×10-2) in high to low quartile comparison.CONCLUSIONS: A high GRS is associated with increased risk of organ damage, renal dysfunction and all-cause mortality. Our results indicate that genetic profiling may be useful for predicting outcomes in patients with SLE.

Hitta via bibliotek

Annals of the Rheumatic Diseases (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reumatologi och ...

Artiklar i publikationen: Annals of the Rh ...

Av lärosätet: Uppsala universitet; Umeå universitet; Lunds universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus

Ämnesord

Nyckelord

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub