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Programmed DNA elim...
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Kinsella, Cormac M.Uppsala universitet,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab,Univ Amsterdam, Amsterdam UMC, Dept Med Microbiol, Lab Expt Virol, NL-1105 AZ Amsterdam, Netherlands
(author)
Programmed DNA elimination of germline development genes in songbirds
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-11-29
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NATURE PUBLISHING GROUP,2019
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-400663
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-400663URI
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https://doi.org/10.1038/s41467-019-13427-4DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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In some eukaryotes, germline and somatic genomes differ dramatically in their composition. Here we characterise a major germline-soma dissimilarity caused by a germline-restricted chromosome (GRC) in songbirds. We show that the zebra finch GRC contains >115 genes paralogous to single-copy genes on 18 autosomes and the Z chromosome, and is enriched in genes involved in female gonad development. Many genes are likely functional, evidenced by expression in testes and ovaries at the RNA and protein level. Using comparative genomics, we show that genes have been added to the GRC over millions of years of evolution, with embryonic development genes bicc1 and trim71 dating to the ancestor of songbirds and dozens of other genes added very recently. The somatic elimination of this evolutionarily dynamic chromosome in songbirds implies a unique mechanism to minimise genetic conflict between germline and soma, relevant to antagonistic pleiotropy, an evolutionary process underlying ageing and sexual traits.
Subject headings and genre
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Ruiz-Ruano, Francisco J.Uppsala universitet,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab,Systematisk biologi,Univ Granada, Dept Genet, E-18071 Granada, Spain(Swepub:uu)fraru543
(author)
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Dion-Cote, Anne-MarieUppsala universitet,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab,Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA;Univ Moncton, Dept Biol, Moncton, NB E1A 3E9, Canada(Swepub:uu)anndi744
(author)
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Charles, Alexander J.Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England
(author)
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Gossmann, Toni I.Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England;Bielefeld Univ, Dept Anim Behav, D-33501 Bielefeld, Germany
(author)
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Cabrero, JosefaUniv Granada, Dept Genet, E-18071 Granada, Spain
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Kappei, DennisNatl Univ Singapore, Canc Sci Inst Singapore, Singapore 117599, Singapore;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117596, Singapore
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Hemmings, NicolaUniv Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England
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Simons, Mirre J. P.Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England
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Camacho, Juan Pedro M.Univ Granada, Dept Genet, E-18071 Granada, Spain
(author)
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Forstmeier, WolfgangMax Planck Inst Ornithol, D-82319 Seewiesen, Germany
(author)
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Suh, AlexanderUppsala universitet,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab,Systematisk biologi(Swepub:uu)alesu519
(author)
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Uppsala universitetEvolutionsbiologi
(creator_code:org_t)
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In:Nature Communications: NATURE PUBLISHING GROUP102041-1723
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