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Sökning: id:"swepub:oai:DiVA.org:uu-400826" > Toxicity study on C...

  • Murugesu, SuganyaInt Islamic Univ Malaysia, Dept Pharmaceut Chem, Kulliyyah Pharm, Pharmacognosy Res Grp, Kuantan, Pahang Darul Ma, Malaysia;Univ Kuala Lumpur, Fac Pharm & Hlth Sci, Perak Darul Ridzuan, Royal Coll Med Perak, Ipoh 30450, Perak Darul Rid, Malaysia (författare)

Toxicity study on Clinacanthus nutans leaf hexane fraction using Danio rerio embryos

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • ELSEVIER,2019
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-400826
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-400826URI
  • https://doi.org/10.1016/j.toxrep.2019.10.020DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Clinacanthus nutans, an herbal shrub belonging to the Acanthaceae family, is traditionally used as a functional food to treat various ailments in Malaysia and Indonesia. Although the polar fraction of this plant shows nontoxic effect, the toxicity of the non-polar extract is not reported so far. The present study aimed to assess the toxic effect and determine the lethal concentration of this non-polar fraction using zebrafish embryos. The n-hexane fraction was partitioned from the crude extract of C. nutans obtained using 80% methanolic solution. After spawning of the adult male and female zebrafish, the eggs were collected, transferred into a 96-well plate and incubated with the n-hexane fraction at concentrations of 15.63 mu g/ml, 31.25 mu g/ml, 62.5 mu g/ml, 125 mu g/ml, 250 mu g/ml and 500 mu g/ml in 2% DMSO. The survival and sublethal endpoint were assessed, the mortality and hatchability rates were calculated based on microscopic observation, while the heartbeat rate was measured using DanioScope software. The median lethal concentration (LC50) of the C. nutans n-hexane fraction, which was determined using probit analysis, was calculated to be 75.49 mu g/mL, which is harmful. Moreover, gas chromatography-mass spectrometry (GC-MS) analysis revealed the presence of palmitic acid, phytol, hexadecanoic acid, 1-monopalmitin, stigmast-5-ene, pentadecanoic acid, heptadecanoic acid, 1-linolenoylglycerol and stigmasterol in the n-hexane fraction.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Khatib, AlfiInt Islamic Univ Malaysia, Dept Pharmaceut Chem, Kulliyyah Pharm, Pharmacognosy Res Grp, Kuantan, Pahang Darul Ma, Malaysia;Univ Malaysia, Int Islamic, Kulliyyah Sci, Cent Res & Anim Facil, Kuantan 25200, Pahang Darul Ma, Malaysia;Airlangga Univ, Fac Pharm, Surabaya 60155, Indonesia (författare)
  • Ahmed, Qamar UddinInt Islamic Univ Malaysia, Dept Pharmaceut Chem, Kulliyyah Pharm, Pharmacognosy Res Grp, Kuantan, Pahang Darul Ma, Malaysia (författare)
  • Ibrahim, ZalikhaInt Islamic Univ Malaysia, Dept Pharmaceut Chem, Kulliyyah Pharm, Pharmacognosy Res Grp, Kuantan, Pahang Darul Ma, Malaysia (författare)
  • Uzir, Bisha FathamahInt Islamic Univ Malaysia, Dept Pharmaceut Chem, Kulliyyah Pharm, Pharmacognosy Res Grp, Kuantan, Pahang Darul Ma, Malaysia (författare)
  • Benchoula, KhaledInt Islamic Univ Malaysia, Dept Pharmaceut Chem, Kulliyyah Pharm, Pharmacognosy Res Grp, Kuantan, Pahang Darul Ma, Malaysia (författare)
  • Yusoff, Nik Idris NikInt Islamic Univ Malaysia, Dept Pharmaceut Chem, Kulliyyah Pharm, Pharmacognosy Res Grp, Kuantan, Pahang Darul Ma, Malaysia (författare)
  • Perumal, VikneswariUniv Kuala Lumpur, Fac Pharm & Hlth Sci, Perak Darul Ridzuan, Royal Coll Med Perak, Ipoh 30450, Perak Darul Rid, Malaysia (författare)
  • Alajmi, Mohamed F.King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia (författare)
  • Salamah, SahalKing Saud Bin Abdul Aziz Univ Hlth Sci, Jeddah 21423, Saudi Arabia (författare)
  • El-Seedi, HeshamUppsala universitet,Farmakognosi,Al Rayan Coll, Al Rayan Res & Innovat Ctr, Medina 42541, Saudi Arabia;Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China(Swepub:uu)heels173 (författare)
  • Int Islamic Univ Malaysia, Dept Pharmaceut Chem, Kulliyyah Pharm, Pharmacognosy Res Grp, Kuantan, Pahang Darul Ma, Malaysia;Univ Kuala Lumpur, Fac Pharm & Hlth Sci, Perak Darul Ridzuan, Royal Coll Med Perak, Ipoh 30450, Perak Darul Rid, MalaysiaInt Islamic Univ Malaysia, Dept Pharmaceut Chem, Kulliyyah Pharm, Pharmacognosy Res Grp, Kuantan, Pahang Darul Ma, Malaysia;Univ Malaysia, Int Islamic, Kulliyyah Sci, Cent Res & Anim Facil, Kuantan 25200, Pahang Darul Ma, Malaysia;Airlangga Univ, Fac Pharm, Surabaya 60155, Indonesia (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Toxicology reports: ELSEVIER6, s. 1148-11542214-7500

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