Search: (WFRF:(Norman Paul E.)) pers:(Voelzke Henry) >
Phenome-wide associ...
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Schmidt, Amand F.UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England;Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Dept Cardiol, Utrecht, Netherlands;UCLs BHF Res Accelerator Ctr, London, England
(author)
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-10-29
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BMC,2019
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-401186
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-401186URI
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https://doi.org/10.1186/s12872-019-1187-zDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. Methods: Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included, providing data on 79,578 participants. Results were scaled to a one mmol/L lower LDL-C concentration. Results: The PCSK9 GS (comprising 4 SNPs) associations with plasma lipid and apolipoprotein levels were consistent in direction with treatment effects. The GS odds ratio (OR) for myocardial infarction (MI) was 0.53 (95% CI 0.42; 0.68), compared to a PCSK9 inhibitor effect of 0.90 (95% CI 0.86; 0.93). For ischemic stroke ORs were 0.84 (95% CI 0.57; 1.22) for the GS, compared to 0.85 (95% CI 0.78; 0.93) in the drug trials. ORs with type 2 diabetes mellitus (T2DM) were 1.29 (95% CI 1.11; 1.50) for the GS, as compared to 1.00 (95% CI 0.96; 1.04) for incident T2DM in PCSK9 inhibitor trials. No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer's disease - outcomes for which large-scale trial data were unavailable. Conclusions: Genetic variation at the PCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI. While indicating an increased risk of T2DM, no other possible safety concerns were shown; although precision was moderate.
Subject headings and genre
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Holmes, Michael V.Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Med Res Council Populat Hlth Res Unit, Oxford, England;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Oxford, England
(author)
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Preiss, DavidUniv Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Med Res Council Populat Hlth Res Unit, Oxford, England;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Oxford, England
(author)
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Swerdlow, Daniel I.UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England;Imperial Coll London, Dept Med, London, England
(author)
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Denaxas, SpirosUCLs BHF Res Accelerator Ctr, London, England;UCL, Hlth Data Res UK, 222 Euston Rd, London NW1 2DA, England;UCL, Inst Hlth Informat, 222 Euston Rd, London NW1 2DA, England;British Lib, Alan Turing Inst, 96 Euston Rd, London NW1 2DB, England
(author)
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Fatemifar, GhazalehUCLs BHF Res Accelerator Ctr, London, England;UCL, Hlth Data Res UK, 222 Euston Rd, London NW1 2DA, England;UCL, Inst Hlth Informat, 222 Euston Rd, London NW1 2DA, England
(author)
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Faraway, RupertUCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England
(author)
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Finan, ChrisUCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England;UCLs BHF Res Accelerator Ctr, London, England
(author)
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Valentine, DennisUCLs BHF Res Accelerator Ctr, London, England;UCL, Farr Inst Hlth Informat, London, England
(author)
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Fairhurst-Hunter, ZammyUniv Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Richard Doll Bldg,Old Rd Campus,Roosevelt Dr, Oxford OX3 7LF, England;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Richard Doll Bldg,Old Rd Campus,Roosevelt Dr, Oxford OX3 7LF, England
(author)
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Hartwig, Fernando PiresUniv Fed Pelotas, Postgrad Program Epidemiol, Pelotas, RS, Brazil
(author)
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Horta, Bernardo LessaUniv Fed Pelotas, Postgrad Program Epidemiol, Pelotas, RS, Brazil
(author)
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Hypponen, ElinaUniv South Australia, Sansom Inst Hlth Res, Ctr Populat Hlth Res, Adelaide, SA, Australia;UCL GOS Inst Child Hlth, Populat Policy & Practice, London, England;South Australian Hlth & Med Res Inst, Adelaide, SA, Australia
(author)
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Power, ChristineUCL GOS Inst Child Hlth, Populat Policy & Practice, London, England
(author)
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Moldovan, MaxSouth Australian Hlth & Med Res Inst, Adelaide, SA, Australia
(author)
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van Iperen, ErikNetherlands Heart Inst, Durrer Ctr Cardiovasc Res, Utrecht, Netherlands;Acad Med Ctr Amsterdam, Dept Clin Epidemiol Biostat & Bioinformat, Amsterdam, Netherlands
(author)
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Hovingh, KeesAcad Med Ctr Amsterdam, Dept Vasc Med, Amsterdam, Netherlands
(author)
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Demuth, IljaCharite Univ Med Berlin, Berlin, Germany;Free Univ Berlin, Berlin, Germany;Humboldt Univ, Berlin, Germany;Berlin Inst Hlth, Lipid Clin, Interdisciplinary Metab Ctr, Berlin, Germany;Charite Univ Med Berlin, BCRT Berlin Inst Hlth, Ctr Regenerat Therapies, Berlin, Germany
(author)
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Norman, KristinaUniv Potsdam, Inst Nutr Sci, D-14558 Nuthetal, Germany;Charite Univ Med Berlin, Geriatr Res Grp, D-13347 Berlin, Germany;German Inst Human Nutr Potsdam Rehbrucke, Dept Nutr & Gerontol, D-14558 Nuthetal, Germany
(author)
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Steinhagen-Thiessen, ElisabethCharite Univ Med Berlin, Berlin, Germany;Free Univ Berlin, Berlin, Germany;Humboldt Univ, Berlin, Germany;Berlin Inst Hlth, Lipid Clin, Interdisciplinary Metab Ctr, Berlin, Germany
(author)
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Demuth, JuriECA Econ GmbH, Berlin, Germany
(author)
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Bertram, LarsUniv Lubeck, Lubeck Interdisciplinary Platform Genome Analyt L, Inst Neurogenet & Cardiogenet, Lubeck, Germany;Univ Oslo, Dept Psychol, Ctr Lifespan Changes Brain & Cognit LCBC, Oslo, Norway
(author)
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Lill, Christina M.Univ Lubeck, Inst Neurogenet & Cardiogenet, Lubeck Interdisciplinary Platform Genome Analyt L, Genet & Mol Epidemiol Grp, Lubeck, Germany;Inst Human Genet, Lubeck, Germany;Imperial Coll, Sch Publ Hlth, Ageing Epidemiol Res Unit, London, England
(author)
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Coassin, StefanMed Univ Innsbruck, Dept Genet & Pharmacol, Inst Genet Epidemiol, A-6020 Innsbruck, Austria
(author)
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Willeit, JohannMed Univ Innsbruck, Dept Neurol, Innsbruck, Austria
(author)
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Kiechl, StefanMed Univ Innsbruck, Dept Neurol, Innsbruck, Austria
(author)
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Willeit, KarinMed Univ Innsbruck, Dept Neurol, Innsbruck, Austria;Univ Bern, Univ Hosp Bern, Inselspital, Dept Neurol, Bern, Switzerland
(author)
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Mason, DanBradford Royal Infirm, Bradford Inst Hlth Res, Bradford, W Yorkshire, England
(author)
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Wright, JohnBradford Royal Infirm, Bradford Inst Hlth Res, Bradford, W Yorkshire, England
(author)
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Morris, RichardUCL, Dept Primary Care & Populat Hlth, London, England
(author)
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Wanamethee, GoyaUCL, Dept Primary Care & Populat Hlth, London, England
(author)
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Whincup, PeterSt Georges Univ London, Populat Hlth Res Inst, London, England
(author)
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Ben-Shlomo, YoavUniv Bristol, Populat Hlth Sci, Bristol, Avon, England
(author)
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McLachlan, StelaUniv Edinburgh, Usher Inst, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland
(author)
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Price, Jackie F.Univ Edinburgh, Usher Inst, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland
(author)
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Kivimaki, MikaUCL, UCL Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, London, England
(author)
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Welch, CatherineUCL, UCL Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, London, England
(author)
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Sanchez-Galvez, AdelaidaUCL, UCL Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, London, England
(author)
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Marques-Vidal, PedroLausanne Univ Hosp, Dept Med, Internal Med, Lausanne, Switzerland
(author)
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Nicolaides, AndrewImperial Coll, Dept Vasc Surg, London, England;Univ Nicosia, Nicosia Med Sch, Dept Surg, Nicosia, Cyprus
(author)
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Panayiotou, Andrie G.Cyprus Univ Technol, Cyprus Int Inst Environm & Publ Hlth, Limassol, Cyprus
(author)
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Onland-Moret, N. CharlotteUniv Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
(author)
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van der Schouw, Yvonne T.Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
(author)
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Matullo, GiuseppeIIGM, Turin, Italy;Univ Turin, Dept Med Sci, Turin, Italy
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Fiorito, GiovanniIIGM, Turin, Italy;Univ Turin, Dept Med Sci, Turin, Italy
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Guarrera, SimonettaIIGM, Turin, Italy;Univ Turin, Dept Med Sci, Turin, Italy
(author)
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Sacerdote, CarlottaCitta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy;Ctr Canc Prevent CPO, Turin, Italy
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Wareham, Nicholas J.Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, MRC Epidemiol Unit,Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England
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Langenberg, ClaudiaUniv Cambridge, Addenbrookes Hosp, Sch Clin Med, MRC Epidemiol Unit,Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England
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Scott, Robert A.Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, MRC Epidemiol Unit,Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England
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Luan, Jian'anUniv Cambridge, Addenbrookes Hosp, Sch Clin Med, MRC Epidemiol Unit,Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England
(author)
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Bobak, MartinUCL, UCL Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, London, England
(author)
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Malyutina, SofiaNovosibirsk State Med Univ, Novosibirsk, Russia;Russian Acad Med Sci, Siberian Branch, Inst Internal & Prevent Med, Novosibirsk, Russia
(author)
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Pajak, AndrzejJagiellonian Univ, Coll Med, Fac Hlth Sci, Dept Epidemiol & Populat Studies, Krakow, Poland
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Kubinova, RuzenaNatl Inst Publ Hlth, Prague, Czech Republic
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Tamosiunas, AbdonasLithuanian Univ Hlth Sci, Kaunas, Lithuania
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Pikhart, HynekUCL, UCL Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, London, England
(author)
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Grarup, NielsUniv Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark
(author)
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Pedersen, OlufUniv Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark
(author)
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Hansen, TorbenUniv Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark
(author)
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Linneberg, AllanUniv Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark;Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Capital Region, Denmark
(author)
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Jess, TineBispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Capital Region, Denmark
(author)
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Cooper, JackieUCL, Dept Med, Ctr Cardiovasc Genet, London, England
(author)
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Humphries, Steve E.UCL, Dept Med, Ctr Cardiovasc Genet, London, England
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Brilliant, MurrayMarshfield Clin Res Inst, Ctr Human Genet, Marshfield, WI USA
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Kitchner, TerrieMarshfield Clin Res Inst, Ctr Human Genet, Marshfield, WI USA
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Hakonarson, HakonChildrens Hosp Philadelphia, Philadelphia, PA 19104 USA
(author)
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Carrell, David S.Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA
(author)
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McCarty, Catherine A.Univ Minnesota, Minneapolis, MN USA
(author)
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Lester, Kirchner H.Geisinger, Danville, PA USA
(author)
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Larson, Eric B.Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA
(author)
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Crosslin, David R.Univ Washington Seattle, Dept Biomed Informat & Med Educ, Seattle, WA USA
(author)
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de Andrade, MarizaMayo Clin, Rochester, MN USA
(author)
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Roden, Dan M.Vanderbilt Univ, Sch Med, Dept Med, Dept Pharmacol,Dept Biomed Informat, Nashville, TN 37212 USA
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Denny, Joshua C.Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA
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Carty, CaraWHI, Seattle, WA USA
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Hancock, StephenUniv Newcastle, Newcastle, NSW, Australia
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Attia, JohnUniv Newcastle, Newcastle, NSW, Australia;Hunter Med Res Inst, Publ Hlth Program, Newcastle, NSW, Australia
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Holliday, ElizabethUniv Newcastle, Newcastle, NSW, Australia;Hunter Med Res Inst, Publ Hlth Program, Newcastle, NSW, Australia
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Scott, RodneyUniv Newcastle, Newcastle, NSW, Australia
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Schofield, PeterHunter New England Local Hlth Dist, Newcastle, NSW, Australia
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O'Donnell, MartinPopulat Hlth Res Inst, Hamilton, ON, Canada
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Yusuf, SalimPopulat Hlth Res Inst, Hamilton, ON, Canada
(author)
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Chong, MichaelPopulat Hlth Res Inst, Hamilton, ON, Canada
(author)
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Pare, GuillaumePopulat Hlth Res Inst, Hamilton, ON, Canada
(author)
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van der Harst, PimNetherlands Heart Inst, Durrer Ctr Cardiovasc Res, Utrecht, Netherlands;Acad Med Ctr Amsterdam, Dept Clin Epidemiol Biostat & Bioinformat, Amsterdam, Netherlands;Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands;Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
(author)
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Said, M. AbdullahUniv Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
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Eppinga, Ruben N.Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
(author)
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Verweij, NiekUniv Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
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Snieder, HaroldUniv Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands
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Christen, TimLeiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands
(author)
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Mook-Kanamori, D. O.Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands
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Gustafsson, StefanUppsala universitet,Molekylär epidemiologi(Swepub:uu)stegu732
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Lind, LarsUppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA;(Swepub:uu)larslind
(author)
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Ingelsson, Erik,1975-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA(Swepub:uu)ering425
(author)
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Pazoki, RahaErasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Imperial Coll London, Dept Epidemiol & Biostat, London, England
(author)
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Franco, OscarErasmus MC, Dept Epidemiol, Rotterdam, Netherlands
(author)
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Hofman, AlbertErasmus MC, Dept Epidemiol, Rotterdam, Netherlands
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Uitterlinden, AndreErasmus MC, Dept Epidemiol, Rotterdam, Netherlands
(author)
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Dehghan, AbbasErasmus MC, Dept Epidemiol, Rotterdam, Netherlands
(author)
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Teumer, AlexanderUniv Med Greifswald, Inst Community Med, Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany
(author)
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Baumeister, SebastianUniv Med Greifswald, Inst Community Med, Greifswald, Germany;Ludwig Maximilians Univ Munchen, Chair Epidemiol, UNIKA T Augsburg, Augsburg, Germany
(author)
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Doerr, MarcusDZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany
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Lerch, Markus M.Univ Med Greifswald, Dept Internal Med A, Greifswald, Germany
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Voelker, UweDZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany
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Voelzke, HenryUniv Med Greifswald, Inst Community Med, Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany
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Ward, JoeyUniv Glasgow, Inst Hlth & Wellbeing, Glasgow G12 8RZ, Lanark, Scotland
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Pell, Jill P.Univ Glasgow, Inst Hlth & Wellbeing, Glasgow G12 8RZ, Lanark, Scotland
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Meade, TomLondon Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London, England
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Christophersen, Ingrid E.Vestre Viken Hosp Trust, Baerum Hosp, Dept Med Res, Gjettum, Norway
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Maitland-van der Zee, Anke H.Univ Utrecht, Fac Sci, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands;Univ Amsterdam, Acad Med Ctr, Dept Resp Med, Amsterdam, Netherlands
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Baranova, Ekaterina V.Univ Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland
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Young, RobinUniv Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland
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Ford, IanUniv Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland
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Campbell, ArchieUniv Edinburgh, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland
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Padmanabhan, SandoshUniv Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8TA, Lanark, Scotland
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Bots, Michiel L.Cyprus Univ Technol, Cyprus Int Inst Environm & Publ Hlth, Limassol, Cyprus
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Grobbee, Diederick E.Cyprus Univ Technol, Cyprus Int Inst Environm & Publ Hlth, Limassol, Cyprus
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Froguel, PhilippeUniv Lille, Inst Pasteur Lille, CNRS, UMR 8199,EGID, F-59000 Lille, France;Imperial Coll London, Dept Genom Common Dis, London W12 0NN, England
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Thuillier, DorotheeUniv Lille, Inst Pasteur Lille, CNRS, UMR 8199,EGID, F-59000 Lille, France
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Roussel, RonanINSERM, Ctr Rech Cordeliers, U1138, Paris, France;Univ Paris Diderot, Sorbonne Paris Cite, UFR Med, Paris, France;Hop Bicha, AP HP, Dept Diabetol Endocrinol & Nutr, Paris, France
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Bonnefond, AmelieUniv Lille, Inst Pasteur Lille, CNRS, UMR 8199,EGID, F-59000 Lille, France
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Cariou, BertrandUniv Nantes, CHU Nantes, CNRS, Inst Thorax,INSERM, Nantes, France
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Smart, MelissaUniv Essex, Inst Social & Econ Res, Colchester, Essex, England
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Bao, YanchunUniv Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
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Kumari, MeenaBoston Univ, Sch Med, Boston, MA 02118 USA
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Mahajan, AnubhaUniv Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
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Hopewell, Jemma C.Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Richard Doll Bldg,Old Rd Campus,Roosevelt Dr, Oxford OX3 7LF, England;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Richard Doll Bldg,Old Rd Campus,Roosevelt Dr, Oxford OX3 7LF, England
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Seshadri, SudhaBoston Univ, Sch Med, Boston, MA 02118 USA
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Dale, CarolineUCL, Farr Inst Hlth Informat, London, England
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Costa, Rui Providencia E.UCL, Farr Inst Hlth Informat, London, England
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Ridker, Paul M.Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Brigham & Womens Hosp, Boston, MA 02115 USA
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Chasman, Daniel I.Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Brigham & Womens Hosp, Boston, MA 02115 USA
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Reiner, Alex P.UWash, Seattle, WA USA
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Ritchie, Marylyn D.Penn State, State Coll, PA USA
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Lange, Leslie A.Univ Colorado Denver, Denver, CO USA
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Cornish, Alex J.Inst Canc Res, Div Genet & Epidemiol, London, England
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Dobbins, Sara E.Inst Canc Res, Div Genet & Epidemiol, London, England
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Hemminki, KariGerman Canc Res Ctr, Div Mol Genet Epidemiol, Neuenheimer Feld 580, D-69120 Heidelberg, Germany;Deutsch Krebsforschungszentrum, Heidelberg, Germany
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Kinnersley, BenInst Canc Res, Div Genet & Epidemiol, London, England
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Sanson, MarcInst Cerveau Moelle Epiniere ICM, Paris, France;UPMC Univ Paris 06, Sorbonne Univ, UMR S 1127, F-75013 Paris, France
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Labreche, KarimInst Cerveau Moelle Epiniere ICM, Paris, France;UPMC Univ Paris 06, Sorbonne Univ, UMR S 1127, F-75013 Paris, France
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Simon, MatthiasBethel Clin, Dept Neurosurg, Kantensiek 11, D-33617 Bielefeld, Germany
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Bondy, MelissaBaylor Coll Med, Dan L Duncan Canc Ctr, Dept Pediat, Div Hematol Oncol, Houston, TX 77030 USA
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Law, PhilipInst Canc Res, Div Genet & Epidemiol, London, England
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Speedy, HelenInst Canc Res, Div Genet & Epidemiol, London, England
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Allan, JamesNewcastle Univ, Northern Inst Canc Res, Newcastle Upon Tyne, Tyne & Wear, England
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Li, NiInst Canc Res, Div Genet & Epidemiol, London, England
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Went, MollyInst Canc Res, Div Genet & Epidemiol, London, England
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Weinhold, NielsUniv Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA
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Morgan, GarethUniv Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA
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Sonneveld, PieterErasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands
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Nilsson, BjornDept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden
(author)
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Goldschmidt, HartmutUniv Clin Heidelberg, Internal Med 5, Heidelberg, Germany;Natl Ctr Tumor Dis NCT, Heidelberg, Germany
(author)
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Sud, AmitInst Canc Res, Div Genet & Epidemiol, London, England
(author)
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Engert, AndreasUniv Hosp Cologne, Dept Internal Med, Cologne, Germany
(author)
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Hansson, MarkusSkane Univ Hosp, Hematol Clin, Skane, Sweden;Lund Univ, Wallenberg Ctr Mol Med, Lund, Sweden
(author)
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Hemingway, HarryUCLs BHF Res Accelerator Ctr, London, England;UCL, Hlth Data Res UK, 222 Euston Rd, London NW1 2DA, England;UCL, Inst Hlth Informat, 222 Euston Rd, London NW1 2DA, England;UCL, Univ Coll London Hosp, Biomed Res Ctr, Natl Inst Hlth Res, 222 Euston Rd, London NW1 2DA, England
(author)
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Asselbergs, Folkert W.UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England;Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Dept Cardiol, Utrecht, Netherlands;UCLs BHF Res Accelerator Ctr, London, England;UCL, Hlth Data Res UK, London, England;UCL, Inst Hlth Informat, London, England
(author)
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Patel, Riyaz S.UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England;UCLs BHF Res Accelerator Ctr, London, England;St Bartholomews Hosp, Barts Heart Ctr, London, England
(author)
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Keating, Brendan J.Univ Penn, Philadelphia, PA 19104 USA
(author)
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Sattar, NaveedUniv Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8TA, Lanark, Scotland
(author)
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Houlston, RichardInst Canc Res, Div Genet & Epidemiol, London, England
(author)
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Casas, Juan P.Vet Affairs Boston Healthcare Syst, Massachusetts Vet Epidemiol & Res Informat Ctr MA, Boston, MA USA
(author)
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Hingorani, Aroon D.UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England;UCLs BHF Res Accelerator Ctr, London, England
(author)
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UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England;Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Dept Cardiol, Utrecht, Netherlands;UCLs BHF Res Accelerator Ctr, London, EnglandUniv Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Med Res Council Populat Hlth Res Unit, Oxford, England;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Oxford, England
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In:BMC Cardiovascular Disorders: BMC19:11471-22611471-2261
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Uppsala University