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The Alternative Com...
The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure
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- Holt, Margrethe Flesvig (author)
- Oslo Univ Hosp, Norway;Oslo University Hospital Rikshospitalet, Norway
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- Michelsen, Annika E. (author)
- Oslo Univ Hosp, Norway;Univ Oslo, Norway
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- Shahini, Negar (author)
- Oslo Univ Hosp, Norway
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- Bjorkelund, Elisabeth (author)
- Oslo University Hospital Rikshospitalet, Norway
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- Bendz, Christina Holt (author)
- Oslo University Hospital Rikshospitalet, Norway
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- Massey, Richard J. (author)
- Oslo University Hospital Rikshospitalet, Norway;Univ Oslo, Norway
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- Schjalm, Camilla (author)
- Oslo University Hospital Rikshospitalet, Norway;Univ Oslo, Norway
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- Halvorsen, Bente (author)
- Oslo Univ Hosp, Norway;Univ Oslo, Norway
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- Broch, Kaspar (author)
- Oslo University Hospital Rikshospitalet, Norway;Univ Oslo, Norway
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- Ueland, Thor (author)
- Oslo Univ Hosp, Norway;Univ Oslo, Norway;The Arctic University of Norway, Norway
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- Gullestad, Lars (author)
- Oslo University Hospital Rikshospitalet, Norway;Univ Oslo, Norway
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- Nilsson, Per H., 1980- (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Avancerade material,Oslo University Hospital Rikshospitalet, Norway;University of Oslo, Norway,Linnaeus Ctr Biomat Chem, BMC;HoRB
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- Aukrust, Pål (author)
- Oslo University Hospital Rikshospitalet, Norway;University of Oslo, Norway
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- Mollnes, Tom Eirik (author)
- Oslo University Hospital Rikshospitalet, Norway;University of Oslo, Norway;The Arctic University of Norway, Norway;Nordland Hospital, Norway;Norwegian University of Science and Technology, Norway
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- Louwe, Mieke C. (author)
- Oslo University Hospital, Norway
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(creator_code:org_t)
- 2021-12-24
- 2021
- English.
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In: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 12
- Related links:
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https://doi.org/10.3...
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- Objective: Dysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase C3bBbP are elevated in these patients. We hypothesized that plasma levels of FB and C3bBbP would be associated with disease severity and survival in patients with HF. Methods: We analyzed plasma levels of FB, C3bBbP, and terminal C5b-9 complement complex (TCC) in 343 HF patients and 27 healthy controls. Results: Compared with controls, patients with HF had elevated levels of circulating FB (1.6-fold, p < 0.001) and C3bBbP (1.3-fold, p < 0.001). In contrast, TCC, reflecting the terminal pathway, was not significantly increased (p = 0.15 vs controls). FB was associated with NT-proBNP, troponin, eGFR, and i.e., C-reactive protein. FB, C3bBbP and TCC were not associated with mortality in HF during a mean follow up of 4.3 years. Conclusion: Our findings suggest that in patients with HF, the alternative pathway is activated. However, this is not accompanied by activation of the terminal pathway.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- heart failure
- complement
- alternative pathway
- complement Factor B
- C3bBbP
- terminal complement complex
- Medicin
- Medicine
- Immunologi
- Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Holt, Margrethe ...
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Michelsen, Annik ...
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Shahini, Negar
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Bjorkelund, Elis ...
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Bendz, Christina ...
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Massey, Richard ...
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show more...
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Schjalm, Camilla
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Halvorsen, Bente
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Broch, Kaspar
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Ueland, Thor
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Gullestad, Lars
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Nilsson, Per H., ...
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Aukrust, Pål
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Mollnes, Tom Eir ...
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Louwe, Mieke C.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Frontiers in Imm ...
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Linnaeus University