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Cerebrospinal fluid...
Cerebrospinal fluid biomarkers of inflammation in trigeminal neuralgia patients operated with microvascular decompression
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- Ericson, Hans, 1959- (author)
- Uppsala universitet,Enblad: Neurokirurgi,Neurokirurgi,Uppsala Univ, Sweden
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- Abu Hamdeh, Sami (author)
- Uppsala universitet,Enblad: Neurokirurgi,Uppsala Univ, Sweden
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- Freyhult, Eva, 1979- (author)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin,Uppsala Univ, Sweden
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- Stiger, Fredrik (author)
- Uppsala universitet,Anestesiologi och intensivvård,Uppsala Univ, Sweden
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- Bäckryd, Emmanuel (author)
- Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Svenningsson, Anders (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Gordh, Torsten (author)
- Uppsala universitet,Anestesiologi och intensivvård,Uppsala Univ, Sweden
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- Kultima, Kim (author)
- Uppsala universitet,Klinisk kemi,Uppsala Univ, Sweden
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(creator_code:org_t)
- 2019-08-01
- 2019
- English.
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In: Pain. - : Ovid Technologies (Wolters Kluwer Health). - 0304-3959 .- 1872-6623. ; 160:11, s. 2603-2611
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https://doi.org/10.1...
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Abstract
Subject headings
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- Compression of the trigeminal root entry zone by a blood vessel can cause trigeminal neuralgia (TN). However, a neurovascular conflict does not explain all cases of TN, and TN can exist without a neurovascular contact. A common observation during microvascular decompression surgery to treat TN is arachnoiditis in the region of the trigeminal nerve. Thus, aberrant inflammatory mechanisms may be involved in the pathophysiology of TN but information about the role of inflammation in TN is scarce. We used Proximity Extension Assay technology to analyse the levels of 92 protein biomarkers related to inflammation in lumbar cerebrospinal fluid from patients with TN (n = 27) before and after microvascular decompression compared to individuals without TN. We aimed to analyse the pattern of inflammation-related proteins in order to improve our understanding of the pathophysiology of TN. The main finding was that immunological protein levels in the cerebrospinal fluid from patients with TN decreased after surgery towards levels observed in healthy controls. Two proteins seemed to be of specific interest for TN: TRAIL and TNF-beta. Thus, inflammatory activity might be one important mechanism in TN.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Neurokirurgi
- Neurosurgery
- Trigeminal neuralgia; Microvascular decompression; Biomarkers; PEA; Inflammation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ericson, Hans, 1 ...
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Abu Hamdeh, Sami
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Freyhult, Eva, 1 ...
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Stiger, Fredrik
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Bäckryd, Emmanue ...
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Svenningsson, An ...
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show more...
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Gordh, Torsten
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Kultima, Kim
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Pain
- By the university
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Uppsala University
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Karolinska Institutet
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Linköping University