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Engineered antibodi...
Engineered antibodies : new possibilities for brain PET?
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- Sehlin, Dag, 1976- (författare)
- Uppsala universitet,Geriatrik
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- Syvänen, Stina (författare)
- Uppsala universitet,Geriatrik
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- Ballanger, Benedicte (författare)
- Lyon Neurosci Res Ctr, Lyon, France
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Barthel, Henryk (författare)
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- Bischof, Gerard N. (författare)
- Univ Cologne, Univ Hosp Cologne, Cologne, Germany
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- Boche, Delphine (författare)
- Univ Southampton, Southampton, Hants, England
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- Boecker, Hennig (författare)
- Univ Leipzig, Univ Hosp Leipzig, Leipzig, Germany;German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
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- Bohn, Karl Peter (författare)
- Univ Cologne, Univ Hosp Cologne, Cologne, Germany
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- Borghammer, Per (författare)
- Aarhus Univ, Aarhus, Denmark
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- Cross, Donna (författare)
- Univ Utah, Salt Lake City, UT 84112 USA
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- Di Monte, Donato (författare)
- German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
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- Drzezga, Alexander (författare)
- Univ Cologne, Univ Hosp Cologne, Cologne, Germany;Res Ctr Julich, Julich, Germany
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- Endepols, Heike (författare)
- Univ Cologne, Univ Hosp Cologne, Cologne, Germany
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- Giehl, Kathrin (författare)
- Univ Cologne, Univ Hosp Cologne, Cologne, Germany
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- Goedert, Michel (författare)
- MRC, Mol Biol Lab, Cambridge, England
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- Hammes, Jochen (författare)
- Univ Cologne, Univ Hosp Cologne, Cologne, Germany
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- Hansson, Oskar (författare)
- Lund Univ, Lund, Sweden
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- Herholz, Karl (författare)
- Univ Manchester, Manchester, Lancs, England
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- Hoeglinger, Guenter (författare)
- German Ctr Neurodegenerat Dis DZNE, Munich, Germany
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- Hoenig, Merle (författare)
- Univ Cologne, Univ Hosp Cologne, Cologne, Germany
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- Jessen, Frank (författare)
- Univ Cologne, Univ Hosp Cologne, Cologne, Germany
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- Klockgether, Thomas (författare)
- German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
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- Lafaye, Pierre (författare)
- Inst Pasteur, Paris, France
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- Lammerstma, Adriaan (författare)
- Univ Amsterdam, Med Ctr, Amsterdam, Netherlands
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Mandelkow, Eckhard (författare)
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Mandelkow, Eva-Maria (författare)
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- Maurer, Andreas (författare)
- Univ Tubingen Hosp, Tubingen, Germany
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- Mollenhauer, Brit (författare)
- Univ Med Ctr Gottingen, Gottingen, Germany
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- Neumaier, Bernd (författare)
- Res Ctr Julich, Julich, Germany
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- Nordberg, Agneta (författare)
- Karolinska Institutet
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Onur, Ozgur (författare)
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- Reetz, Kathrin (författare)
- Univ Hosp Aachen, Aachen, Germany
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- Rodriguez-Vietez, Elena (författare)
- Karolinska Inst, Stockholm, Sweden
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- Rominger, Axel (författare)
- Univ Bern, Bern, Switzerland
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- Rowe, James (författare)
- Univ Cambridge, Cambridge, England;MRC, Cognit & Brain Sci Unit, Cambridge, England
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- Sabri, Osama (författare)
- Univ Leipzig, Univ Hosp Leipzig, Leipzig, Germany
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Schneider, Anja (författare)
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- Strafella, Antonio (författare)
- Univ Toronto, Toronto, ON, Canada;Toronto Western Hosp, UHN, Toronto, ON, Canada
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van Eimeren, Thilo (författare)
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- Vasdev, Neil (författare)
- Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada
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- Villemagne, Victor (författare)
- Austin Hlth, Heidelberg, Vic, Australia
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- Willbold, Dieter (författare)
- Res Ctr Julich, Julich, Germany
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(creator_code:org_t)
- 2019-07-24
- 2019
- Engelska.
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Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - : SPRINGER. - 1619-7070 .- 1619-7089. ; 46:13, s. 2848-2858
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Almost 50 million people worldwide are affected by Alzheimer's disease (AD), the most common neurodegenerative disorder. Development of disease-modifying therapies would benefit from reliable, non-invasive positron emission tomography (PET) biomarkers for early diagnosis, monitoring of disease progression, and assessment of therapeutic effects. Traditionally, PET ligands have been based on small molecules that, with the right properties, can penetrate the blood-brain barrier (BBB) and visualize targets in the brain. Recently a new class of PET ligands based on antibodies have emerged, mainly in applications related to cancer. While antibodies have advantages such as high specificity and affinity, their passage across the BBB is limited. Thus, to be used as brain PET ligands, antibodies need to be modified for active transport into the brain. Here, we review the development of radioligands based on antibodies for visualization of intrabrain targets. We focus on antibodies modified into a bispecific format, with the capacity to undergo transferrin receptor 1 (TfR1)-mediated transcytosis to enter the brain and access pathological proteins, e.g. amyloid-beta. A number of such antibody ligands have been developed, displaying differences in brain uptake, pharmacokinetics, and ability to bind and visualize the target in the brain of transgenic mice. Potential pathological changes related to neurodegeneration, e.g. misfolded proteins and neuroinflammation, are suggested as future targets for this novel type of radioligand. Challenges are also discussed, such as the temporal match of radionuclide half-life with the ligand's pharmacokinetic profile and translation to human use. In conclusion, brain PET imaging using bispecific antibodies, modified for receptor-mediated transcytosis across the BBB, is a promising method for specifically visualizing molecules in the brain that are difficult to target with traditional small molecule ligands.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Transferrin receptor 1 (TfR1)-mediated transcytosis
- Alzheimer's disease (AD)
- Amyloid-beta (A beta)
- Antibody
- Blood-brain barrier (BBB)
- Positron emission tomography (PET)
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sehlin, Dag, 197 ...
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Syvänen, Stina
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Ballanger, Bened ...
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Barthel, Henryk
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Bischof, Gerard ...
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Boche, Delphine
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visa fler...
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Boecker, Hennig
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Bohn, Karl Peter
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Borghammer, Per
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Cross, Donna
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Di Monte, Donato
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Drzezga, Alexand ...
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Endepols, Heike
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Giehl, Kathrin
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Goedert, Michel
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Hammes, Jochen
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Hansson, Oskar
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Herholz, Karl
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Hoeglinger, Guen ...
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Hoenig, Merle
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Jessen, Frank
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Klockgether, Tho ...
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Lafaye, Pierre
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Lammerstma, Adri ...
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Mandelkow, Eckha ...
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Mandelkow, Eva-M ...
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Maurer, Andreas
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Mollenhauer, Bri ...
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Neumaier, Bernd
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Nordberg, Agneta
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Onur, Ozgur
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Reetz, Kathrin
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Rodriguez-Vietez ...
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Rominger, Axel
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Rowe, James
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Sabri, Osama
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Schneider, Anja
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Strafella, Anton ...
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van Eimeren, Thi ...
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Vasdev, Neil
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Villemagne, Vict ...
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Willbold, Dieter
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Radiologi och bi ...
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European Journal ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet