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The Uppsala-Stockho...
The Uppsala-Stockholm Assisted Reproductive Techniques (UppStART) study
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- Iliadou, Anastasia N. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
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- Öberg, Anna Sara (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
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- Pege, Jessica (författare)
- Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
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- Rodriguez-Wallberg, Kenny A. (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Div Gynecol & Reprod, Dept Reprod Med, Stockholm, Sweden;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden
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- Olofsson, Jan I. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden
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- Holte, Jan (författare)
- Uppsala universitet,Reproduktionsbiologi,Carl von Linne Klin, Uppsala, Sweden;Univ Agr Sci Uppsala, Ctr Reprod Biol Uppsala, Uppsala, Sweden
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- Wramsby, Håkan (författare)
- Livio Fertilitetsctr Kungsholmen, Stockholm, Sweden
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- Wramsby, Margaretha (författare)
- Livio Fertilitetsctr Gardet, Stockholm, Sweden
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- Cnattingius, Sven (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden
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- Cesta, Carolyn E. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol, Stockholm, Sweden
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(creator_code:org_t)
- 2019-08-28
- 2019
- Engelska.
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Ingår i: BMJ Open. - : BMJ PUBLISHING GROUP. - 2044-6055. ; 9
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://bmjopen.bmj....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Purpose: The Uppsala-Stockholm Assisted Reproductive Techniques (UppStART) study is a prospectively recruited sample of couples undergoing assisted reproduction in Stockholm and Uppsala county in Sweden. The study was initiated to (1) investigate possible changes in the epigenetic profile of infants inferred through the ART procedures and their consequence and (2) to assess the impact of lifestyle and health exposures on treatment outcome.Participants: Recruitment took place between September 2011 and December 2013, and in vitro fertilisation (IVF) cycles initiated and pregnancies conceived during this time were followed until December 2014. The cohort includes 971 participants (n= 514 women; n= 457 men), and 129 pregnancies were achieved from the first IVF cycle included in the study.Findings to date: Self-reported demographic, health and lifestyle data were collected from a baseline questionnaire, and to assess changes to lifestyle, a follow-up questionnaire was issued at the time of oocyte retrieval, and at subsequent IVF cycles. Questionnaire data were linked to data extracted from medical records. Biological samples were collected at baseline: blood for extraction of serum, plasma and DNA, morning and evening saliva samples for cortisol measurement and at delivery including samples of maternal blood, placenta and amniotic fluid, and cord blood for epigenetic analysis.Future plans: Through the unique identification number assigned to each Swedish citizen at birth or immigration, UppStART study participants will be linked to the Swedish population-based national and quality registers to provide data from prenatal, obstetrical, neonatal and infant care, and subsequent updates will provide data on childhood health and educational outcomes. Collaboration and use of UppStART data is encouraged, and more information about access can be found at www.ki.se/meb/uppstart
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- assisted reproductive techniques
- in vitro fertilisation
- infertility
- lifestyle
- epigenetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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