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A Multi-Cohort Meta...
A Multi-Cohort Metabolomics Analysis Discloses Sphingomyelin (32:1) Levels to be Inversely Related to Incident Ischemic Stroke
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- Lind, Lars (författare)
- Karolinska Institutet,Uppsala universitet,Klinisk epidemiologi
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- Salihovic, Samira (författare)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Ganna, Andrea (författare)
- Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA;Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA;Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA
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- Sundström, Johan, Professor, 1971- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk epidemiologi
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- Broeckling, Corey D. (författare)
- Colorado State Univ, Prote & Metabol Facil, Ft Collins, CO 80523 USA
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- Magnusson, Patrik K. (författare)
- Karolinska Institutet
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- Pedersen, Nancy L. (författare)
- Karolinska Inst, Dept Med Epidemiol & Biostat MEB, Stockholm, Sweden
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- Siegbahn, Agneta, 1947- (författare)
- Uppsala universitet,Koagulation och inflammationsvetenskap
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- Prenni, Jessica (författare)
- Colorado State Univ, Prote & Metabol Facil, Ft Collins, CO 80523 USA
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- Fall, Tove, 1979- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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- Ingelsson, Erik (författare)
- Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA;Stanford Cardiovasc Inst, Stanford, CA USA
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- Ärnlöv, Johan, 1970- (författare)
- Högskolan Dalarna,Karolinska Institutet,Medicinsk vetenskap
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Journal of Stroke & Cerebrovascular Diseases. - : Elsevier BV. - 1052-3057 .- 1532-8511. ; 29:2
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background and Purpose:To search for novel pathophysiological pathways related to ischemic stroke using a metabolomics approach.Methods: We identified 204 metabolites in plasma by liquid chromatography mass spectrometry in 3 independent population-based samples (TwinGene, Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) and Uppsala Longitudinal Study of Adult Men). TwinGene was used for discovery and the other 2 samples were meta-analyzed as replication. In PIVUS, traditional cardiovascular (CV) risk factors, multiple markers of subclinical CV disease, markers of coagulation/fibrinolysis were measured and analyzed in relation to top metabolites.Results:In TwinGene (177 incident cases, median follow-up 4.3 years), levels of 28 metabolites were associated with incident ischemic stroke at a false discover rate (FDR) of 5%. In the replication (together 194 incident cases, follow-up 10 and 12 years, respectively), only sphingomyelin (32:1) was significantly associated (HR.69 per SD change, 95% CI.57-0.83, P value = .00014; FDR <5%) when adjusted for systolic blood pressure, diabetes, smoking, low density lipoportein (LDL)- and high density lipoprotein (HDL), body mass index (BMI) and atrial fibrillation. In PIVUS, sphingomyelin (32:1) levels were significantly related to both LDL- and HDL-cholesterol in a positive fashion, and to serum triglycerides, BMI and diabetes in a negative fashion. Furthermore, sphingomyelin (32:1) levels were related to vasodilation in the forearm resistance vessels, and inversely to leukocyte count (P < .0069 and .0026, respectively).Conclusions:An inverse relationship between sphingomyelin (32:1) and incident ischemic stroke was identified, replicated, and characterized. A possible protective role for sphingomyelins in stroke development has to be further investigated in additional experimental and clinical studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Epidemiology
- metabolomics
- stroke
- risk factor
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- art (ämneskategori)
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- Av författaren/redakt...
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Lind, Lars
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Salihovic, Samir ...
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Ganna, Andrea
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Sundström, Johan ...
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Broeckling, Core ...
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Magnusson, Patri ...
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visa fler...
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Pedersen, Nancy ...
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Siegbahn, Agneta ...
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Prenni, Jessica
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Fall, Tove, 1979 ...
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Ingelsson, Erik
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Ärnlöv, Johan, 1 ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Journal of Strok ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Högskolan Dalarna