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Sökning: id:"swepub:oai:DiVA.org:uu-403249" > Cervical cancer cas...

  • Wang, JiangrongKarolinska Institutet (författare)

Cervical cancer case-control audit : Results from routine evaluation of a nationwide cervical screening program

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2019-06-03
  • WILEY,2020
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-403249
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-403249URI
  • https://doi.org/10.1002/ijc.32416DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:142657458URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Our study used a refined case-control cervical cancer Audit framework to investigate effectiveness of cervical screening, with measures of three screening failures: irregular-participation, cervical cancer developed after cytological abnormalities and after normal screening results. The register-based study included 4,254 cervical cancer cases diagnosed in Sweden during 2002-2011, and 30 population-based controls per case. We used conditional logistic regression models to examine relative risks of cervical cancer in relation to screening participation and screening results in the past two screening rounds from 6 months before cancer diagnosis. We found that women unscreened in past two screening rounds showed four times increased risk of cervical cancer compared to women screened in time (OR = 4.1, 95% CI = 3.8-4.5), and women unscreened in the previous round but screened in the most recent round also showed a statistically significantly elevated risk (OR = 1.6, 95% CI = 1.5-1.8). Women having abnormality in previous two rounds exhibited higher risk of cervical cancer compared to women screened with normal results, while having normal results in the subsequent round after the abnormality also yielded an increased risk (OR = 4.0, 95% CI = 3.2-5.1). Being screened with only normal results was associated with 89% risk reduction for squamous cell cancer, compared to women unscreened, but only 60% reduction for adenocarcinoma. Our findings emphasize the importance of routine participation in cervical screening and suggest that management of abnormalities, as well as sensitivity of the test, warrants improvement especially for preventing cervical adenocarcinoma. The Audit framework serves as routine evaluation model and the findings benchmark for future evaluation of changes in screening practice.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Elfström, K. MiriamKarolinska Institutet (författare)
  • Andrae, BengtKarolinska Institutet,Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden (författare)
  • Kleppe, Sara NordqvistKarolinska Institutet (författare)
  • Ploner, AlexanderKarolinska Institutet (författare)
  • Lei, JiayaoKarolinska Institutet (författare)
  • Dillner, JoakimKarolinska Institutet (författare)
  • Sundström, KarinKarolinska Institutet (författare)
  • Sparén, PärKarolinska Institutet (författare)
  • Karolinska InstitutetCentrum för klinisk forskning, Gävleborg (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Cancer: WILEY146:5, s. 1230-12400020-71361097-0215

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