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Dapagliflozin in Pa...
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction
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- McMurray, J. J. V. (author)
- Univ Glasgow, BHF Cardiovasc Res Ctr, Glasgow, Lanark, Scotland
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- Solomon, S. D. (author)
- Brigham & Womens Hosp, Cardiovasc Div, 75 Francis St, Boston, MA 02115 USA
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- Inzucchi, S. E. (author)
- Yale Univ, Sch Med, Sect Endocrinol, New Haven, CT USA
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- Kober, L. (author)
- Copenhagen Univ Hosp, Rigshosp, Copenhagen, Denmark
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- Kosiborod, M. N. (author)
- Univ Missouri, St Lukes Mid Amer Heart Inst, Kansas City, MO 64110 USA
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- Martinez, F. A. (author)
- Natl Univ Cordoba, Cordoba, Argentina
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- Ponikowski, P. (author)
- Wroclaw Med Univ, Wroclaw, Poland
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- Sjöstrand, Mikaela, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Anand, I. S. (author)
- Univ Minnesota, Dept Cardiol, Minneapolis, MN USA
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Belohlavek, J. (author)
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- Bohm, M. (author)
- Saarland Univ Hosp, Dept Med, Homburg, Germany
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Chiang, C. -E (author)
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- Chopra, V. K. (author)
- Medanta, Dept Cardiol, Gurgaon, India
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- de Boer, R. A. (author)
- Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands;Univ Groningen, Groningen, Netherlands
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- Desai, A. S. (author)
- Brigham & Womens Hosp, Cardiovasc Div, 75 Francis St, Boston, MA 02115 USA
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- Diez, M. (author)
- Inst Cardiovasc Buenos Aires, Div Cardiol, Buenos Aires, DF, Argentina
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- Drozdz, J. (author)
- Med Univ Lodz, Dept Cardiol, Lodz, Poland
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- Dukat, A. (author)
- Comenius Univ, Dept Internal Med 5, Bratislava, Slovakia
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- Ge, J. (author)
- Shanghai Inst Cardiovasc Dis, Dept Cardiol, Shanghai, Peoples R China;Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China
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- Howlett, J. G. (author)
- Univ Calgary, Cumming Sch Med, Calgary, AB, Canada;Univ Calgary, Libin Cardiovasc Inst, Calgary, AB, Canada
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- Katova, T. (author)
- Natl Cardiol Hosp, Clin Cardiol, Sofia, Bulgaria
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- Kitakaze, M. (author)
- Natl Cerebral & Cardiovasc Ctr, Cardiovasc Div Med, Osaka, Japan
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- Ljungman, Charlotta, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Merkely, B. (author)
- Semmelweis Univ, Heart & Vasc Ctr, Budapest, Hungary
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- Nicolau, J. C. (author)
- Univ Sao Paolo, Fac Med, Hosp Clin, Sao Paulo, Brazil
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- O'Meara, E. (author)
- Montreal Heart Inst, Dept Cardiol, Montreal, PQ, Canada
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- Petrie, M. C. (author)
- Univ Glasgow, BHF Cardiovasc Res Ctr, Glasgow, Lanark, Scotland
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- Vinh, P. N. (author)
- Tan Tao Univ, Dept Internal Med, Tan Duc, Vietnam
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- Schou, M. (author)
- Gentofte Univ Hosp, Dept Cardiol, Copenhagen, Denmark
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- Tereshchenko, S. (author)
- Natl Med Res Ctr Cardiol, Dept Myocardial Dis & Heart Failure, Moscow, Russia
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- Verma, S. (author)
- Univ Toronto, St Michaels Hosp, Div Cardiac Surg, Toronto, ON, Canada
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- Held, Claes, 1956- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- DeMets, D. L. (author)
- Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI 53706 USA
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- Docherty, K. F. (author)
- Univ Glasgow, BHF Cardiovasc Res Ctr, Glasgow, Lanark, Scotland
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- Jhund, P. S. (author)
- Univ Glasgow, BHF Cardiovasc Res Ctr, Glasgow, Lanark, Scotland
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- Bengtsson, O. (author)
- AstraZeneca, Gothenburg, Sweden
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- Sjostrand, M. (author)
- AstraZeneca, Gothenburg, Sweden
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Langkilde, A. -M (author)
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(creator_code:org_t)
- 2019
- 2019
- English.
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In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 381:21, s. 1995-2008
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND In patients with type 2 diabetes, inhibitors of sodium-glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through glucose-independent mechanisms. More data are needed regarding the effects of SGLT2 inhibitors in patients with established heart failure and a reduced ejection fraction, regardless of the presence or absence of type 2 diabetes.METHODS In this phase 3, placebo-controlled trial, we randomly assigned 4744 patients with New York Heart Association class II, III, or IV heart failure and an ejection fraction of 40% or less to receive either dapagliflozin (at a dose of 10 mg once daily) or placebo, in addition to recommended therapy. The primary outcome was a composite of worsening heart failure (hospitalization or an urgent visit resulting in intravenous therapy for heart failure) or cardiovascular death.RESULTS Over a median of 18.2 months, the primary outcome occurred in 386 of 2373 patients (16.3%) in the dapagliflozin group and in 502 of 2371 patients (21.2%) in the placebo group (hazard ratio, 0.74; 95% confidence interval [CI], 0.65 to 0.85; P<0.001). A first worsening heart failure event occurred in 237 patients (10.0%) in the dapagliflozin group and in 326 patients (13.7%) in the placebo group (hazard ratio, 0.70; 95% CI, 0.59 to 0.83). Death from cardiovascular causes occurred in 227 patients (9.6%) in the dapagliflozin group and in 273 patients (11.5%) in the placebo group (hazard ratio, 0.82; 95% CI, 0.69 to 0.98); 276 patients (11.6%) and 329 patients (13.9%), respectively, died from any cause (hazard ratio, 0.83; 95% CI, 0.71 to 0.97). Findings in patients with diabetes were similar to those in patients without diabetes. The frequency of adverse events related to volume depletion, renal dysfunction, and hypoglycemia did not differ between treatment groups.CONCLUSIONS Among patients with heart failure and a reduced ejection fraction, the risk of worsening heart failure or death from cardiovascular causes was lower among those who received dapagliflozin than among those who received placebo, regardless of the presence or absence of diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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McMurray, J. J. ...
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Solomon, S. D.
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Inzucchi, S. E.
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Kober, L.
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Kosiborod, M. N.
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Martinez, F. A.
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show more...
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Ponikowski, P.
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Sjöstrand, Mikae ...
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Anand, I. S.
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Belohlavek, J.
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Bohm, M.
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Chiang, C. -E
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Chopra, V. K.
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de Boer, R. A.
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Desai, A. S.
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Diez, M.
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Drozdz, J.
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Dukat, A.
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Ge, J.
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Howlett, J. G.
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Katova, T.
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Kitakaze, M.
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Ljungman, Charlo ...
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Merkely, B.
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Nicolau, J. C.
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O'Meara, E.
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Petrie, M. C.
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Vinh, P. N.
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Schou, M.
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Tereshchenko, S.
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Verma, S.
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Held, Claes, 195 ...
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DeMets, D. L.
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Docherty, K. F.
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Jhund, P. S.
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Bengtsson, O.
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Sjostrand, M.
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Langkilde, A. -M
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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New England Jour ...
- By the university
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Uppsala University
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University of Gothenburg