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Radiation dosimetry...
Radiation dosimetry of para-chloro-2-[18F]fluoroethyl-etomidate:a PET tracer for adrenocortical imaging
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- Silins, Isabella, 1983- (författare)
- Uppsala universitet,Endokrinkirurgi
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- Moreno, Adrian (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Wall, Anders (författare)
- Uppsala universitet,Radiologi
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- Aigbirhio, Franklin (författare)
- Wolfson Brain Imaging Centre, University of Cambridge, England
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- Gurnell, Mark (författare)
- Institute of Metabolic Science & Department of Medicine, University of Cambridge, England
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- Brown, Morris (författare)
- William Harvey Heart Centre, Queen Mary University of London, England
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- Roslin, Sara (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Antoni, Gunnar (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Hellman, Per (författare)
- Uppsala universitet,Endokrinkirurgi
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- Sundin, Anders, 1954- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Radiologi
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Introduction[11C]metomidate, a methyl ester analogue of etomidate, is used for positron emission tomography of adrenocortical cancer, and has been tested in recent clinical trials for lateralization in primary aldosteronism (PA). However, in PA, visualization as well as uptake quantification are hampered by the tracer’s rather high non-specific liver uptake, and its overall clinical usefulness is also limited by the short 20-minute half-life of carbon-11. Therefore, we evaluated para-chloro-2-[18F]fluoroethyl-etomidate, [18F]CETO, a fluorine-18 (T1/2=109.8 min) analogue, as a potential new adrenocortical PET tracer.ObjectivesThe aim of this study was to assess in vivo and in-human radiation dosimetry of [18F]CETO.Methods: Residence times were calculated based on uptake data from rats (n=30, biodistribution study with ex vivo measurements) as well as in vivo PET/CT in cynomolgus (n=1) and humans (n=9). OLINDA 1.1 was used to obtain absorbed doses in human organs (mGy/MBq) and effective dose (mSv/MBq).Results[18F]CETO showed a high uptake in human adrenal glands, still increasing at 90 minutes post injection. Regardless of species used for input data (rat, cynomolgus or human), adrenal glands (absorbed dose 0.093 ± 0.038 mGy/MBq based on human data) were confirmed as the dose-limiting organs. The effective dose based on human data was 18.2 μSv/MBq and varied little when using rat (18.4 μSv/MBq) or cynomolgus data (16.1 μSv/MBq). Conclusions[18F]CETO has a favourable biodistribution in humans for adrenal imaging. The effective dose for a typical clinical PET/CT examination with 200 MBq [18F]CETO is 3.6 mSv.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- [18F]CETO
- positron emission tomography
- primary aldosteronism
- adrenal
- tumour
- adenoma
- Conn adenoma
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)
- Av författaren/redakt...
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Silins, Isabella ...
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Moreno, Adrian
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Wall, Anders
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Aigbirhio, Frank ...
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Gurnell, Mark
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Brown, Morris
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visa fler...
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Roslin, Sara
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Antoni, Gunnar
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Hellman, Per
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Sundin, Anders, ...
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Lubberink, Mark
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
- Av lärosätet
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Uppsala universitet