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Secondary ossificat...
Secondary ossification center induces and protects growth plate structure
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- Xie, Meng (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Gol'din, Pavel (författare)
- Department of Evolutionary Morphology, Schmalhausen Institute of Zoology of NAS of Ukraine, Ukraine
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- Nele Herdina, Anna (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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visa fler...
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- Estefa, Jordi, 1987- (författare)
- Uppsala universitet,Institutionen för organismbiologi
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- Medvedeva, Ekaterina (författare)
- Division of Anatomy, MIC, Medical University of Vienna, Austria,Institute for Regenerative Medicine, Sechenov University, Russia
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- Li, Lei (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Newton, Phillip (författare)
- Department of Women’s and Children’s Health, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Sweden,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Kotova, Svetlana (författare)
- Semenov Institute of Chemical Physics, Russia,Institute for Regenerative Medicine, Sechenov University, Russia
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- Shavkuta, Boris (författare)
- Institute of Photonic Technologies, Research center "Crystallography and Photonics", Russia,Institute for Regenerative Medicine, Sechenov University, Russia
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- Saxena, Aditya (författare)
- Division of Biological Sciences, University of California San Diego, USA
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- Shumate, Lauren (författare)
- Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A.
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- Metscher, Brian (författare)
- Department of Theoretical Biology, University of Vienna, Austria
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- Grossschmidt, Karl (författare)
- Bone and Biomaterials Research, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria
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- Nishimori, Shigeki (författare)
- Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A.
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- Akovantseva, Anastasia (författare)
- Institute of Photonic Technologies, Research center "Crystallography and Photonics", Russia,Institute for Regenerative Medicine, Sechenov University, Russia
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- Linares Arregui, Irene (författare)
- Department of Solid Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden
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- Tafforeau, Paul (författare)
- European Synchrotron Radiation Facility, Grenoble, France
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- Fried, Kaj (författare)
- Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Carlström, Mattias (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Simon, Andras (författare)
- Department of Cell and Molecular Biology, Centre of Developmental Biology for Regenerative Medicine, Karolinska Institute, Stockholm, Sweden
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- Gasser, Christian (författare)
- Department of Solid Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden
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- Kronenberg, Henry (författare)
- Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A.
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- Bastepe, Murat (författare)
- Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A.
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- Cooper, Kimberly (författare)
- Division of Biological Sciences, University of California San Diego, USA
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- Timashev, Peter (författare)
- Semenov Institute of Chemical Physics, Russia,Institute for Regenerative Medicine, Sechenov University, Russia
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- Sanchez, Sophie (författare)
- Uppsala universitet,Institutionen för organismbiologi
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- Adameyko, Igor (författare)
- Department of Molecular Neurosciences, Medical University of Vienna, Austria,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Eriksson, Anders (författare)
- Department of Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden
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- Chagin, Andrei (författare)
- Institute for Regenerative Medicine, Sechenov University, Russia,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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visa färre...
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(creator_code:org_t)
- Engelska.
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Ingår i: eLIFE. - 2050-084X.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Growth plate and articular cartilage constitute a single anatomical entity, but later separate into two distinct structures by the formation of secondary ossification center (SOC). The reason for such spatial separation remains unknown. Here, we demonstrate that evolutionarily SOC first appears in amniotes. Mathematical modelling reveals that SOC reduces mechanical stress within the growth plate. Analysis of mammals with specialized extremities reveals that SOC size correlates with the extent of mechanical demands. Ex and in vivo experiments demonstrate that SOC allows epiphyseal chondrocytes to withstand a several-fold higher load before activation of the YAP-p73 signalling pathway and caspase-dependent apoptosis, with hypertrophic chondrocytes being the most load-sensitive cells. Atomic force microscopy shows that hypertrophic chondrocytes are the least mechanically stiff cells within the growth plate. Altogether, these findings suggest that SOC is evolved to protect epiphyseal chondrocytes, especially the hypertrophic chondrocytes, from the high mechanical stress encountered in the terrestrial environment.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Xie, Meng
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Gol'din, Pavel
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Nele Herdina, An ...
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Estefa, Jordi, 1 ...
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Medvedeva, Ekate ...
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Li, Lei
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visa fler...
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Newton, Phillip
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Kotova, Svetlana
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Shavkuta, Boris
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Saxena, Aditya
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Shumate, Lauren
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Metscher, Brian
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Grossschmidt, Ka ...
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Nishimori, Shige ...
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Akovantseva, Ana ...
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Linares Arregui, ...
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Tafforeau, Paul
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Fried, Kaj
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Carlström, Matti ...
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Simon, Andras
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Gasser, Christia ...
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Kronenberg, Henr ...
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Bastepe, Murat
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Cooper, Kimberly
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Timashev, Peter
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Sanchez, Sophie
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Adameyko, Igor
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Eriksson, Anders
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Chagin, Andrei
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Uppsala universitet