SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Jensen Gorm Boje)
 

Sökning: WFRF:(Jensen Gorm Boje) > Prognosis And Recla...

Prognosis And Reclassification By YKL-40 In Stable Coronary Artery Disease

Schroder, Jakob (författare)
Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
Jakobsen, Janus Christian (författare)
Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark;Department of Cardiology, Holbæk Hospital, Holbæk, Denmark;Department of Regional Health Research, The Faculty of Heath Sciences, University of Southern Denmark, Odense, Denmark
Winkel, Per (författare)
Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
visa fler...
Hilden, Jørgen (författare)
Section of Biostatistics, Department of Public Health Research, University of Copenhagen, Copenhagen, Denmark
Jensen, Gorm Boje (författare)
Department of Cardiology, Hvidovre Hospital, Copenhagen University Hospital, Copenhagen, Denmark
Sajadieh, Ahmad (författare)
Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
Larsson, Anders (författare)
Uppsala universitet,Klinisk kemi
Ärnlöv, Johan, 1970- (författare)
Högskolan Dalarna,Karolinska Institutet,Medicinsk vetenskap,Karolinska institutet
Harutyunyan, Marina (författare)
Department of Cardiology, Rigshospitalet, University of Copenhagen, København, Denmark
Johansen, Julia S. (författare)
Department of Medicine, Herlev and Gentofte Hospital, Copenhagen, Denmark
Kjøller, Erik (författare)
Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark;Department of Cardiology S, Herlev Hospital University of Copenhagen, Denmark
Gluud, Christian (författare)
Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Kastrup, Jens (författare)
Department of Cardiology, Rigshospitalet, University of Copenhagen, København, Denmark
visa färre...
 (creator_code:org_t)
2020
2020
Engelska.
Ingår i: Journal of the American Heart Association. - 2047-9980 .- 2047-9980. ; 9:5
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BackgroundThe inflammatory biomarker YKL‐40 has previously been studied as a potential risk marker in cardiovascular disease. We aimed to assess the prognostic reclassification potential of serum YKL‐40 in patients with stable coronary artery disease.Methods and ResultsThe main study population was the placebo group of the CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease) trial. The primary outcome was a composite of acute myocardial infarction, unstable angina pectoris, cerebrovascular disease, and all‐cause mortality. We used Cox proportional hazards regression models adjusted for C‐reactive protein level and baseline cardiovascular risk factors. Improvement in prediction by adding serum YKL‐40 to the risk factors was calculated using the Cox‐Breslow method and c‐statistic. A total of 2200 patients were randomized to placebo, with a follow‐up duration of 10 years. YKL‐40 was associated with an increased risk of the composite outcome (hazard ratio per unit increase in (YKL‐40) 1.13, 95% CI 1.03–1.24, P=0.013) and all‐cause mortality (hazard ratio 1.32, 95% CI 1.17–1.49, P<0.0001). Considering whether a composite‐outcome event was more likely to have, or not have, occurred to date, we found 68.4% of such predictions to be correct when based on the standard predictors, and 68.5% when serum YKL‐40 was added as a predictor. Equivalent results were obtained with c‐statistics.ConclusionsHigher serum YKL‐40 was independently associated with an increased risk of adverse cardiovascular outcomes and mortality. Addition of YKL‐40 did not improve risk prediction in patients with stable coronary artery disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

CHI3L1
YKL‐40
cohort study
coronary atherosclerosis
Hälsa och välfärd

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy