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Long‐term follow‐up...
Long‐term follow‐up of antivascular endothelial growth factor treatment for diabetic macular oedema : a four‐year real‐world study
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- Granstam, Elisabet, 1963- (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Department of Ophthalmology, Västmanland County Hospital, Västerås
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- Rosenblad Karlsson, Andreas, Fil. dr, 1973- (författare)
- Stockholms universitet,Uppsala universitet,Klinisk diabetologi och metabolism,Arbets- och miljömedicin,Centrum för klinisk forskning, Västerås,Department of Statistics, Stockholm University,Statistiska institutionen,Uppsala University, Sweden
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Modher Raghib, Aseel (författare)
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- Granström, Therese (författare)
- Högskolan Dalarna,Uppsala universitet,Klinisk diabetologi och metabolism,School of Education, Health and Social Studies, Dalarna University, Falun,Omvårdnad,Uppsala University Hospital, Uppsala University
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- Eriksson, Jan (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Lindholm Olinder, Anna, PhD, 1960- (författare)
- Karolinska Institutet
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- Leksell, Janeth (författare)
- Högskolan Dalarna,Uppsala universitet,Klinisk diabetologi och metabolism,School of Education, Health and Social Studies, Dalarna University, Falun,Omvårdnad,Uppsala University Hospital, Uppsala University
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(creator_code:org_t)
- 2019-10-27
- 2020
- Engelska.
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Ingår i: Acta Ophthalmologica. - : Wiley. - 1755-375X .- 1755-3768. ; 98:4, s. 360-367
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- PurposeTo evaluate visual acuity (VA) and central retinal thickness (CRT) on optical coherence tomography during a 4‐year period in patients treated for sight‐threatening diabetic macular oedema (DMO) at two Swedish county hospitals. Additionally, to compare health‐related quality of life and subjective visual functioning before and after 4 years of treatment.MethodsFifty‐eight patients with DMO were evaluated after 4 years of antivascular endothelial growth factor (VEGF) treatment. VA, CRT and clinical data were retrospectively reviewed. Health‐related quality of life and subjective visual functioning were evaluated with Short Form Health Survey (SF‐36) and National Eye Institute Vision Functioning Questionnaire 25 (VFQ‐25). Comparisons between independent groups were performed using Pearson's χ2 test, Fisher's exact test or Mann–Whitney U test. Spearman's ρ was used for correlation analyses. Wilcoxon signed‐rank test was used for comparison between dependent groups. Logistic regression analysis was applied for analysis of VA and CRT over 4 years.ResultsFollow‐up data were obtained from 37 of 58 (63.8%) patients. Baseline characteristics were similar, regardless of follow‐up. VA improvement at 1 year (mean + 4.4, SD 7.5; ETDRS letter score) was maintained over 3 years, then declined. CRT was reduced throughout the study. In the first treatment year, eyes received 5.1 (1.4) anti‐VEGF injections, followed by approximately two injections yearly. Additional treatment included laser and dexamethasone implants. SF‐36 showed no change at 4 years, compared with baseline. VFQ‐25 demonstrated improvement in near vision activities (p = 0.036).ConclusionSignificant long‐term improvement in visual function was present in patients with anti‐VEGF‐treated DMO.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- anti-VEGF treatment
- diabetic macular oedema
- longitudinal study
- long-term follow-up
- real-world study
- visual acuity
- Medicinsk vetenskap
- Medical Science
- Hälsa och välfärd
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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