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Effects of 1-year a...
Effects of 1-year anti-TNF-α therapies on bone mineral density and bone biomarkers in rheumatoid arthritis and ankylosing spondylitis
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- Gulyas, Katalin (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary;Dept Sports Med, Debrecen, Debrecen, Hungary
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- Horvath, Agnes (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Vegh, Edit (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Pusztai, Anita (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Szentpetery, Agnes (author)
- Uppsala universitet,Reumatologi,Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary;Vincent's Univ Hosp, Univ Coll Dublin, Conway Inst BioMol Res, Dept Rheumatol, St, Dublin, Ireland
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- Petho, Zsofia (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Vancsa, Andrea (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Bodnar, Nora (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Csomor, Peter (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Hamar, Attila (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Bodoki, Levente (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Bhattoa, Harjit Pal (author)
- Univ Debrecen, Fac Med, Dept Lab Med, Debrecen, Debrecen, Hungary
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- Juhasz, Balazs (author)
- Univ Debrecen, Fac Med, Dept Oncology, Debrecen, Debrecen, Hungary
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- Nagy, Zoltan (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Hodosi, Katalin (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Karosi, Tamas (author)
- Borsod Cty Teaching Hosp, Dept Otolaryngology, Miskolc, Miskolc, Hungary
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- FitzGerald, Oliver (author)
- Vincent's Univ Hosp, Univ Coll Dublin, Conway Inst BioMol Res, Dept Rheumatol, St, Dublin, Ireland
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- Szucs, Gabriella (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Szekanecz, Zoltan (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Szamosi, Szilvia (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
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- Szanto, Sandor (author)
- Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary;Dept Sports Med, Debrecen, Debrecen, Hungary
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(creator_code:org_t)
- 2019-09-14
- 2020
- English.
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In: Clinical Rheumatology. - : Springer Science and Business Media LLC. - 0770-3198 .- 1434-9949. ; 39:1, s. 167-175
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Abstract
Subject headings
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- ObjectivesRheumatoid arthritis (RA) and ankylosing spondylitis (AS) have been associated with generalized and localized bone loss. We conducted a comprehensive study using imaging (dual-energy X-ray absorptiometry, DXA) and laboratory biomarkers in order to determine bone health and to study the effects of anti-tumor necrosis factor (TNF) biologics in RA and AS.Patients and methodsThirty-six RA and 17 AS patients undergoing 1-year etanercept (ETN) or certolizumab-pegol (CZP) therapy were studied. Bone density was assessed by DXA at baseline and after 12 months. Serum C-reactive protein (CRP), calcium, phosphate, parathyroid hormone (PTH), vitamin D3, osteocalcin, procollagen type I N-propeptide (P1NP), C-terminal telopeptide (βCTX), osteoprotegerin, sclerostin (SOST), Dickkopf-1 (DKK-1), soluble receptor activator nuclear kappa B ligand (sRANKL), and cathepsin K (cathK) levels were determined at baseline and after 6 and 12 months.ResultsTNF-α inhibition was clinically effective. Anti-TNF-α halted further bone loss over 1 year. In general, anti-TNF therapy significantly increased P1NP, SOST levels, and the P1NP/βCTX ratios, while decreased DKK-1 and CathK production at different time points in most patient subsets. In the full cohort and in RA, baseline and/or 12-month bone mineral density (BMD) at multiple sites exerted inverse relationships with CRP and βCTX, and positive correlation with SOST. In AS, L2-4 BMD after 1-year biologic therapy inversely correlated with baseline βCTX, while femoral neck BMD rather showed inverse correlations with CRP.ConclusionsAnti-TNF therapy slowed down generalized bone loss, in association with clinical improvements, in both diseases. TNF blockade may enhance bone formation and suppress joint destruction. Anti-TNF therapy may act inversely on DKK-1 and SOST. Independent predictors of BMD were SOST and βCTX in RA, whilst CRP in AS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Biologics
- Bone loss
- DKK-1
- Erosion
- JAK inhibitors
- Osteoporosis
- Osteoprotegerin
- RANKL
- Rheumatoid arthritis
- Sclerostin
- Spondyloarthritis
- Syndesmophyte
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gulyas, Katalin
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Horvath, Agnes
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Vegh, Edit
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Pusztai, Anita
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Szentpetery, Agn ...
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Petho, Zsofia
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Vancsa, Andrea
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Bodnar, Nora
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Csomor, Peter
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Hamar, Attila
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Bodoki, Levente
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Bhattoa, Harjit ...
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Juhasz, Balazs
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Nagy, Zoltan
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Hodosi, Katalin
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Karosi, Tamas
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FitzGerald, Oliv ...
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Szucs, Gabriella
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Szekanecz, Zolta ...
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Szamosi, Szilvia
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Szanto, Sandor
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Clinical Rheumat ...
- By the university
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Uppsala University