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  • Gulyas, KatalinUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary;Dept Sports Med, Debrecen, Debrecen, Hungary (author)

Effects of 1-year anti-TNF-α therapies on bone mineral density and bone biomarkers in rheumatoid arthritis and ankylosing spondylitis

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2019-09-14
  • Springer Science and Business Media LLC,2020
  • electronicrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-407442
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-407442URI
  • https://doi.org/10.1007/s10067-019-04771-3DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • ObjectivesRheumatoid arthritis (RA) and ankylosing spondylitis (AS) have been associated with generalized and localized bone loss. We conducted a comprehensive study using imaging (dual-energy X-ray absorptiometry, DXA) and laboratory biomarkers in order to determine bone health and to study the effects of anti-tumor necrosis factor (TNF) biologics in RA and AS.Patients and methodsThirty-six RA and 17 AS patients undergoing 1-year etanercept (ETN) or certolizumab-pegol (CZP) therapy were studied. Bone density was assessed by DXA at baseline and after 12 months. Serum C-reactive protein (CRP), calcium, phosphate, parathyroid hormone (PTH), vitamin D3, osteocalcin, procollagen type I N-propeptide (P1NP), C-terminal telopeptide (βCTX), osteoprotegerin, sclerostin (SOST), Dickkopf-1 (DKK-1), soluble receptor activator nuclear kappa B ligand (sRANKL), and cathepsin K (cathK) levels were determined at baseline and after 6 and 12 months.ResultsTNF-α inhibition was clinically effective. Anti-TNF-α halted further bone loss over 1 year. In general, anti-TNF therapy significantly increased P1NP, SOST levels, and the P1NP/βCTX ratios, while decreased DKK-1 and CathK production at different time points in most patient subsets. In the full cohort and in RA, baseline and/or 12-month bone mineral density (BMD) at multiple sites exerted inverse relationships with CRP and βCTX, and positive correlation with SOST. In AS, L2-4 BMD after 1-year biologic therapy inversely correlated with baseline βCTX, while femoral neck BMD rather showed inverse correlations with CRP.ConclusionsAnti-TNF therapy slowed down generalized bone loss, in association with clinical improvements, in both diseases. TNF blockade may enhance bone formation and suppress joint destruction. Anti-TNF therapy may act inversely on DKK-1 and SOST. Independent predictors of BMD were SOST and βCTX in RA, whilst CRP in AS.

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  • Horvath, AgnesUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Vegh, EditUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Pusztai, AnitaUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Szentpetery, AgnesUppsala universitet,Reumatologi,Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary;Vincent's Univ Hosp, Univ Coll Dublin, Conway Inst BioMol Res, Dept Rheumatol, St, Dublin, Ireland (author)
  • Petho, ZsofiaUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Vancsa, AndreaUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Bodnar, NoraUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Csomor, PeterUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Hamar, AttilaUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Bodoki, LeventeUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Bhattoa, Harjit PalUniv Debrecen, Fac Med, Dept Lab Med, Debrecen, Debrecen, Hungary (author)
  • Juhasz, BalazsUniv Debrecen, Fac Med, Dept Oncology, Debrecen, Debrecen, Hungary (author)
  • Nagy, ZoltanUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Hodosi, KatalinUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Karosi, TamasBorsod Cty Teaching Hosp, Dept Otolaryngology, Miskolc, Miskolc, Hungary (author)
  • FitzGerald, OliverVincent's Univ Hosp, Univ Coll Dublin, Conway Inst BioMol Res, Dept Rheumatol, St, Dublin, Ireland (author)
  • Szucs, GabriellaUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Szekanecz, ZoltanUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Szamosi, SzilviaUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (author)
  • Szanto, SandorUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary;Dept Sports Med, Debrecen, Debrecen, Hungary (author)
  • Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary;Dept Sports Med, Debrecen, Debrecen, HungaryUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary (creator_code:org_t)

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  • In:Clinical Rheumatology: Springer Science and Business Media LLC39:1, s. 167-1750770-31981434-9949

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