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Measures of body fa...
Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer : risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer
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- Genkinger, J. M. (författare)
- Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, Med Ctr, New York, NY 10019 USA;Columbia Univ, Herbert Irving Comprehens Canc Ctr, Canc Epidemiol Program, Med Ctr, New York, NY 10019 USA
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- Wu, K. (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA
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- Wang, M. (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA;Harvard Med Sch, Dept Med, Boston, MA 02115 USA
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- Albanes, D. (författare)
- NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA
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- Black, A. (författare)
- NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA
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- van den Brandt, P. A. (författare)
- Maastricht Univ, Grow Sch Oncol & Dev Biol, Dept Epidemiol, Maastricht, Netherlands
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- Burke, K. A. (författare)
- Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, Med Ctr, New York, NY 10019 USA
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- Cook, M. B. (författare)
- NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA
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- Gapstur, S. M. (författare)
- Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA
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- Giles, G. G. (författare)
- Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia
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- Giovannucci, E. (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard Med Sch, Dept Med, Boston, MA 02115 USA
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- Goodman, G. G. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
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- Goodman, P. J. (författare)
- SWOG Stat Ctr, Seattle, WA USA
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- Håkansson, N. (författare)
- Karolinska Institutet
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- Key, T. J. (författare)
- Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England
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- Mannistö, S. (författare)
- Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland
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- Le Marchand, L. (författare)
- Univ Hawaii, Epidemiol Program, Canc Ctr, Honolulu, HI 96822 USA
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- Liao, L. M. (författare)
- NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA
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- MacInnis, R. J. (författare)
- Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia
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- Neuhouser, M. L. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
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- Platz, E. A. (författare)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
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- Sawada, N. (författare)
- Natl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan
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- Schenk, J. M. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
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- Stevens, V. L. (författare)
- Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA
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- Travis, R. C. (författare)
- Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England
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- Tsugane, S. (författare)
- Natl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan
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- Visvanathan, K. (författare)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
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- Wilkens, L. R. (författare)
- Univ Hawaii, Epidemiol Program, Canc Ctr, Honolulu, HI 96822 USA
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- Wolk, Alicja (författare)
- Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden
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- Smith-Warner, S. A. (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
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(creator_code:org_t)
- OXFORD UNIV PRESS, 2020
- 2020
- Engelska.
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Ingår i: Annals of Oncology. - : OXFORD UNIV PRESS. - 0923-7534 .- 1569-8041. ; 31:1, s. 103-114
- Relaterad länk:
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http://www.annalsofo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Advanced prostate cancer etiology is poorly understood. Few studies have examined associations of anthropometric factors (e.g. early adulthood obesity) with advanced prostate cancer risk.Patients and methods: We carried out pooled analyses to examine associations between body fatness, height, and prostate cancer risk. Among 830 772 men, 51 734 incident prostate cancer cases were identified, including 4762 advanced (T4/N1/M1 or prostate cancer deaths) cases, 2915 advanced restricted (same as advanced, but excluding localized cancers that resulted in death) cases, 9489 high-grade cases, and 3027 prostate cancer deaths. Cox proportional hazards models were used to calculate study-specific hazard ratios (HR) and 95% confidence intervals (CI); results were pooled using random effects models.Results: No statistically significant associations were observed for body mass index (BMI) in early adulthood for advanced, advanced restricted, and high-grade prostate cancer, and prostate cancer mortality. Positive associations were shown for BMI at baseline with advanced prostate cancer (HR = 1.30, 95% CI = 0.95-1.78) and prostate cancer mortality (HR = 1.52, 95% CI = 1.12-2.07) comparing BMI >= 35.0 kg/m(2) with 21-22.9 kg/m(2). When considering early adulthood and baseline BMI together, a 27% higher prostate cancer mortality risk (95% CI = 9% to 49%) was observed for men with BMI <25.0 kg/m(2) in early adulthood and BMI >= 30.0 kg/m(2) at baseline compared with BMI <25.0 kg/m(2) in early adulthood and BMI <30.0 kg/m(2) at baseline. Baseline waist circumference, comparing >= 110 cm with <90 cm, and waist-to-hip ratio, comparing >= 1.00 with <0.90, were associated with significant 14%-16% increases in high-grade prostate cancer risk and suggestive or significant 20%-39% increases in prostate cancer mortality risk. Height was associated with suggestive or significant 33%-56% risks of advanced or advanced restricted prostate cancer and prostate cancer mortality, comparing >= 1.90 m with <1.65 m.Conclusion: Our findings suggest that height and total and central adiposity in mid-to-later adulthood, but not early adulthood adiposity, are associated with risk of advanced forms of prostate cancer. Thus, maintenance of healthy weight may help prevent advanced prostate cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- BMI
- body fatness
- height
- pooled analysis
- prostate cancer
- waist
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Genkinger, J. M.
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Wu, K.
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Wang, M.
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Albanes, D.
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Black, A.
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van den Brandt, ...
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visa fler...
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Burke, K. A.
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Cook, M. B.
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Gapstur, S. M.
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Giles, G. G.
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Giovannucci, E.
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Goodman, G. G.
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Goodman, P. J.
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Håkansson, N.
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Key, T. J.
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Mannistö, S.
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Le Marchand, L.
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Liao, L. M.
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MacInnis, R. J.
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Neuhouser, M. L.
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Platz, E. A.
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Sawada, N.
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Schenk, J. M.
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Stevens, V. L.
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Travis, R. C.
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Tsugane, S.
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Visvanathan, K.
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Wilkens, L. R.
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Wolk, Alicja
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Smith-Warner, S. ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Annals of Oncolo ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet