Search: id:"swepub:oai:DiVA.org:uu-407643" >
Falciparum malaria ...
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Morgan, Andrew P.Univ North Carolina Chapel Hill, Sch Med, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
(author)
Falciparum malaria from coastal Tanzania and Zanzibar remains highly connected despite effective control efforts on the archipelago
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-01-28
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BMC,2020
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-407643
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-407643URI
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https://doi.org/10.1186/s12936-020-3137-8DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143017672URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Tanzania's Zanzibar archipelago has made significant gains in malaria control over the last decade and is a target for malaria elimination. Despite consistent implementation of effective tools since 2002, elimination has not been achieved. Importation of parasites from outside of the archipelago is thought to be an important cause of malaria's persistence, but this paradigm has not been studied using modern genetic tools.Methods: Whole-genome sequencing (WGS) was used to investigate the impact of importation, employing population genetic analyses of Plasmodium falciparum isolates from both the archipelago and mainland Tanzania. Ancestry, levels of genetic diversity and differentiation, patterns of relatedness, and patterns of selection between these two populations were assessed by leveraging recent advances in deconvolution of genomes from polyclonal malaria infections.Results: Significant decreases in the effective population sizes were inferred in both populations that coincide with a period of decreasing malaria transmission in Tanzania. Identity by descent analysis showed that parasites in the two populations shared long segments of their genomes, on the order of 5 cM, suggesting shared ancestry within the last 10 generations. Even with limited sampling, two of isolates between the mainland and Zanzibar were identified that are related at the expected level of half-siblings, consistent with recent importation.Conclusions: These findings suggest that importation plays an important role for malaria incidence on Zanzibar and demonstrate the value of genomic approaches for identifying corridors of parasite movement to the island.
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Brazeau, Nicholas F.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA
(author)
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Ngasala, BillyUppsala universitet,Internationell barnhälsa och nutrition,Muhimbili Univ Hlth & Allied Sci, Dept Parasitol & Med Entomol, Dar Es Salaam, Tanzania(Swepub:uu)bilng827
(author)
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Mhamilawa, Lwidiko EUppsala universitet,Internationell barnhälsa och nutrition,Muhimbili Univ Hlth & Allied Sci, Dept Parasitol & Med Entomol, Dar Es Salaam, Tanzania(Swepub:uu)lwied894
(author)
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Denton, MadelineUniv North Carolina Chapel Hill, Sch Med, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
(author)
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Msellem, MwinyiMnazi Mmoja Hosp, Training & Res, Zanzibar, Tanzania
(author)
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Morris, UlrikaKarolinska Institutet
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Filer, Dayne L.Univ N Carolina, Curriculum Bioinformat & Computat Biol, Chapel Hill, NC 27599 USA
(author)
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Aydemir, OzkanBrown Univ, Dept Lab Med & Pathol, Providence, RI 02912 USA
(author)
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Bailey, Jeffrey A.Brown Univ, Dept Lab Med & Pathol, Providence, RI 02912 USA
(author)
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Parr, Jonathan B.Univ North Carolina Chapel Hill, Sch Med, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
(author)
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Mårtensson, Andreas,1963-Uppsala universitet,Internationell barnhälsa och nutrition(Swepub:uu)andma331
(author)
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Bjorkman, AndersKarolinska Institutet
(author)
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Juliano, Jonathan J.Univ North Carolina Chapel Hill, Sch Med, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA;Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA;Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
(author)
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Univ North Carolina Chapel Hill, Sch Med, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USAUniv N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA
(creator_code:org_t)
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In:Malaria Journal: BMC191475-2875
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