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  • George, LeenaUniv Leicester, Leicester NIHR Biomed Res Ctr, Inst Lung Hlth, Leicester, Leics, England (author)

Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2019-09-10
  • WILEY,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-407976
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-407976URI
  • https://doi.org/10.1111/all.14016DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143143400URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Whether the clinical or pathophysiologic significance of the "treatable trait" high blood eosinophil count in COPD is the same as for asthma remains controversial. We sought to determine the relationship between the blood eosinophil count, clinical characteristics and gene expression from bronchial brushings in COPD and asthma.Methods: Subjects were recruited into a COPD (emphysema versus airway disease [EvA]) or asthma cohort (Unbiased BIOmarkers in PREDiction of respiratory disease outcomes, U-BIOPRED). We determined gene expression using RNAseq in EvA (n = 283) and Affymetrix microarrays in U-BIOPRED (n = 85). We ran linear regression analysis of the bronchial brushings transcriptional signal versus blood eosinophil counts as well as differential expression using a blood eosinophil > 200 cells/mu L as a cut-off. The false discovery rate was controlled at 1% (with continuous values) and 5% (with dichotomized values).Results: There were no differences in age, gender, lung function, exercise capacity and quantitative computed tomography between eosinophilic versus noneosinophilic COPD cases. Total serum IgE was increased in eosinophilic asthma and COPD. In EvA, there were 12 genes with a statistically significant positive association with the linear blood eosinophil count, whereas in U-BIOPRED, 1197 genes showed significant associations (266 positive and 931 negative). The transcriptome showed little overlap between genes and pathways associated with blood eosinophil counts in asthma versus COPD. Only CST1 was common to eosinophilic asthma and COPD and was replicated in independent cohorts.Conclusion: Despite shared "treatable traits" between asthma and COPD, the molecular mechanisms underlying these clinical entities are predominately different.

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  • Taylor, Adam R.GSK Resp Therapeut Area Unit, Stevenage, Herts, England (author)
  • Esteve-Codina, AnnaBarcelona Inst Sci & Technol, CNAG CRG Ctr Nacl Anal Genom, Ctr Genom Regulat, Barcelona, Spain (author)
  • Soler Artigas, MariaUniv Leicester, Leicester NIHR Biomed Res Ctr, Inst Lung Hlth, Leicester, Leics, England;Barcelona Inst Sci & Technol, CNAG CRG Ctr Nacl Anal Genom, Ctr Genom Regulat, Barcelona, Spain;Univ Autonoma Barcelona, VHIR, Grp Psychiat Mental Hlth & Addict, Psychiat Genet Unit, Barcelona, Spain;Biomed Network Res Ctr Mental Hlth CIBERSAM, Inst Salud Carlos III, Barcelona, Spain (author)
  • Andri Thun, GianBarcelona Inst Sci & Technol, CNAG CRG Ctr Nacl Anal Genom, Ctr Genom Regulat, Barcelona, Spain (author)
  • Bates, StewartGSK Resp Therapeut Area Unit, Stevenage, Herts, England (author)
  • Pavlidis, SteliosImperial Coll London, Airway Dis Sect, Natl Heart & Lung Inst, London, England;Imperial Coll London, Data Sci Inst, London, England (author)
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  • Parr, David G.Univ Hosp Coventry & Warwickshire NHS Trust, Dept Resp Med, Coventry, W Midlands, England (author)
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  • Hohlfeld, JensFraunhofer Inst Toxicol & Expt Med, Hannover, Germany (author)
  • Greulich, TimmPhilipps Univ Marburg, Univ Med Ctr Giessen & Marburg, Dept Med Pulm & Crit Care Med, Marburg, Germany;German Ctr Lung Res DZL, Grosshansdorf, Germany (author)
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  • Timens, WimUniv Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands (author)
  • Hinks, TimothyUniv Oxford, Oxford, England (author)
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  • Richardson, MatthewUniv Leicester, Leicester NIHR Biomed Res Ctr, Inst Lung Hlth, Leicester, Leics, England (author)
  • Venge, PerUppsala universitet,Klinisk kemi(Swepub:uu)pervenge (author)
  • Heath, SimonBarcelona Inst Sci & Technol, CNAG CRG Ctr Nacl Anal Genom, Ctr Genom Regulat, Barcelona, Spain (author)
  • Gut, IvoBarcelona Inst Sci & Technol, CNAG CRG Ctr Nacl Anal Genom, Ctr Genom Regulat, Barcelona, Spain;Univ Pompeu Fabra, Barcelona, Spain (author)
  • Tobin, Martin D.Univ Leicester, Leicester NIHR Biomed Res Ctr, Inst Lung Hlth, Leicester, Leics, England (author)
  • Edwards, LindsayGSK Resp Therapeut Area Unit, Stevenage, Herts, England (author)
  • Riley, John H.GSK Resp Therapeut Area Unit, Stevenage, Herts, England (author)
  • Djukanovic, RatkoNIHR Southampton Resp Biomed Res Unit & Clin & Ex, Southampton, Hants, England (author)
  • Auffray, CharlesUniv Lyon, EISBM, CNRS, ENS,UCBL, Lyon 07, France (author)
  • De-Meulder, BertrandUniv Lyon, EISBM, CNRS, ENS,UCBL, Lyon 07, France (author)
  • Erik-Dahlen, SvenKarolinska Inst, Stockholm, Sweden (author)
  • Adcock, Ian M.Biomed Network Res Ctr Mental Hlth CIBERSAM, Inst Salud Carlos III, Barcelona, Spain (author)
  • Chung, Kian FanBiomed Network Res Ctr Mental Hlth CIBERSAM, Inst Salud Carlos III, Barcelona, Spain (author)
  • Ziegler-Heitbrock, LoemsHelmholtz Zentrum Muenchen, EvA Study Ctr, Gauting, Germany;Asklepios Klin, Gauting, Germany (author)
  • Sterk, Peter J.Univ Amsterdam, Med Ctr, Dept Resp Med, Amsterdam, Netherlands (author)
  • Singh, DaveUniv Manchester, Ctr Resp Med & Allergy, Manchester, Lancs, England;Univ Hosp South Manchester NHS Fdn Trust, Med Evaluat Unit, Manchester, Lancs, England (author)
  • Brightling, Christopher E.Univ Leicester, Leicester NIHR Biomed Res Ctr, Inst Lung Hlth, Leicester, Leics, England (author)
  • Univ Leicester, Leicester NIHR Biomed Res Ctr, Inst Lung Hlth, Leicester, Leics, EnglandGSK Resp Therapeut Area Unit, Stevenage, Herts, England (creator_code:org_t)

Related titles

  • In:Allergy. European Journal of Allergy and Clinical Immunology: WILEY75:2, s. 370-3800105-45381398-9995

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