Sökning: L773:1521 6918 OR L773:1532 1916 >
Therapeutic potenti...
Therapeutic potential of an anaerobic cultured human intestinal microbiota, ACHIM, for treatment of IBS
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- Benno, P. (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden
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- Norin, E. (författare)
- Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden
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- Midtvedt, T. (författare)
- Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden
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- Hellström, Per M., 1954- (författare)
- Uppsala universitet,Gastroenterologi/hepatologi
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- Engelska.
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Ingår i: Baillière's Best Practice & Research. - : Elsevier. - 1521-6918 .- 1532-1916. ; 40-41
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- By administering an anaerobic cultivated human intestinal microbiota (ACHIM) via upper gastrointestinal route using endoscopy we aimed to rectify intestinal dysbiosis and simultaneously achieve a treatment response in IBS patients. The study population fulfilled the Rome III IBS criteria and comprised 50 patients. During 10 days, patients recorded the irritable bowel syndrome symptom severity scale (IBS-SSS) along with the Bristol stool scale and number of stools/day. The enrolled patients were categorized as follows: 37 with diarrhea, 5 with constipation and 8 with mixed symptoms. The treatment response showed reduction in a majority of patients, 32 of which with 50-point reduction of IBS-SSS and 21 with a 100-point IBS-SSS reduction. The percentage improvement was 36 (23-49) and 28 (18-38) for women and men respectively. Short-chain fatty acids were not changed. We consider fecal microbiota transplantation in the form of ACHIM as an option for the future therapeutic armamentarium in IBS. (C) 2019 Published by Elsevier Ltd.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Anaerobic cultivated human intestinal microbiota
- Irritable bowel syndrome
- Microbiota transplant
Publikations- och innehållstyp
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