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Utility of animal g...
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Al-Saffar, AhmadUppsala universitet,Gastroenterologi/hepatologi
(författare)
Utility of animal gastrointestinal motility and transit models in functional gastrointestinal disorders
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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Elsevier,2019
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-408003
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-408003URI
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https://doi.org/10.1016/j.bpg.2019.101633DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:for swepub-publicationtype
Anmärkningar
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Alteration in the gastrointestinal (GI) motility and transit comprises an important component of the functional gastrointestinal disorders (FGID). Available animal GI motility and transit models are to study symptoms (delayed gastric emptying, constipation, diarrhea) rather than biological markers to develop an effective treatment that targets the underlying mechanism of altered GI motility in patients. Animal data generated from commonly used methods in human like scintigraphy, breath test and wireless motility capsule may directly translate to the clinic. However, species differences in the control mechanism or pharmacological responses of GI motility may compromise the predictive and translational value of the preclinical data to human. In this review we aim to provide a summary on animal models used to mimic GI motility alteration in FGID, and the impact of the species differences in the physiological and pharmacological responses on the translation of animal GI motility and transit data to human.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Takemi, ShotaSaitama Univ, Grad Sch Sci & Engn, Div Life Sci, Area Regulatory Biol,Sakura Ku, 255 Shimo Ohkubo, Saitama 3388570, Japan
(författare)
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Saaed, Hiwa K.Univ Sulaimani, Coll Pharm, Dept Pharmacol & Toxicol, Sulaymaniyah, Iraq
(författare)
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Sakata, IchiroSaitama Univ, Grad Sch Sci & Engn, Div Life Sci, Area Regulatory Biol,Sakura Ku, 255 Shimo Ohkubo, Saitama 3388570, Japan
(författare)
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Sakai, TakafumiSaitama Univ, Grad Sch Sci & Engn, Div Life Sci, Area Regulatory Biol,Sakura Ku, 255 Shimo Ohkubo, Saitama 3388570, Japan;Saitama Univ, Grad Sch Sci & Engn, Div Strategy Res, Area Life NanoBio,Sakura Ku, 255 Shimo Ohkubo, Saitama 3388570, Japan
(författare)
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Uppsala universitetGastroenterologi/hepatologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Baillière's Best Practice & Research: Elsevier40-411521-69181532-1916
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