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Early appearance of...
Early appearance of key transcription factors influence the spatiotemporal development of the human inner ear
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- Chacko, Lejo Johnson (författare)
- Med Univ Innsbruck, Dept Otorhinolaryngol, Anichstr 35, A-6020 Innsbruck, Austria
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- Sergi, Consolato (författare)
- Univ Alberta, Dept Lab Med & Pathol, 8440 112 St NW, Edmonton, AB T6G 2B7, Canada;Univ Alberta, Dept Pediat, 8440 112 St NW, Edmonton, AB T6G 2B7, Canada
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- Eberharter, Theresa (författare)
- Med Univ Innsbruck, Dept Otorhinolaryngol, Anichstr 35, A-6020 Innsbruck, Austria
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- Dudas, Jozsef (författare)
- Med Univ Innsbruck, Dept Otorhinolaryngol, Anichstr 35, A-6020 Innsbruck, Austria
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- Rask-Andersen, Helge (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar,Uppsala Univ Hosp, Uppsala, Sweden
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- Hoermann, Romed (författare)
- Med Univ Innsbruck, Dept Anat Histol & Embryol, Div Clin & Funct Anat, Muellerstr 59, A-6020 Innsbruck, Austria
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- Fritsch, Helga (författare)
- Med Univ Innsbruck, Dept Anat Histol & Embryol, Div Clin & Funct Anat, Muellerstr 59, A-6020 Innsbruck, Austria
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- Fischer, Natalie (författare)
- Tirol Kliniken, Univ Clin Innsbruck, Anichstr 35, A-6020 Innsbruck, Austria
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- Glueckert, Rudolf (författare)
- Med Univ Innsbruck, Dept Otorhinolaryngol, Anichstr 35, A-6020 Innsbruck, Austria;Tirol Kliniken, Univ Clin Innsbruck, Anichstr 35, A-6020 Innsbruck, Austria
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- Schrott-Fischer, Anneliese (författare)
- Med Univ Innsbruck, Dept Otorhinolaryngol, Anichstr 35, A-6020 Innsbruck, Austria
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(creator_code:org_t)
- 2019-12-02
- 2020
- Engelska.
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Ingår i: Cell and Tissue Research. - : SPRINGER. - 0302-766X .- 1432-0878. ; 379:3, s. 459-471
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Expression patterns of transcription factors leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), transforming growth factor-beta-activated kinase-1 (TAK1), SRY (sex-determining region Y)-box 2 (SOX2), and GATA binding protein 3 (GATA3) in the developing human fetal inner ear were studied between the gestation weeks 9 and 12. Further development of cochlear apex between gestational weeks 11 and 16 (GW11 and GW16) was examined using transmission electron microscopy. LGR5 was evident in the apical poles of the sensory epithelium of the cochlear duct and the vestibular end organs at GW11. Immunostaining was limited to hair cells of the organ of Corti by GW12. TAK1 was immune positive in inner hair cells of the organ of Corti by GW12 and colocalized with p75 neurotrophic receptor expression. Expression for SOX2 was confined primarily to the supporting cells of utricle at the earliest stage examined at GW9. Intense expression for GATA3 was presented in the cochlear sensory epithelium and spiral ganglia at GW9. Expression of GATA3 was present along the midline of both the utricle and saccule in the zone corresponding to the striolar reversal zone where the hair cell phenotype switches from type I to type II. The spatiotemporal gradient of the development of the organ of Corti was also evident with the apex of the cochlea forming by GW16. It seems that highly specific staining patterns of several transcriptions factors are critical in guiding the genesis of the inner ear over development. Our findings suggest that the spatiotemporal gradient in cochlear development extends at least until gestational week 16.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Inner ear
- Human
- Transcription factors
- Immunohistochemistry
- SOX2
- TAK1
- GATA3
- Electron microscopy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Chacko, Lejo Joh ...
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Sergi, Consolato
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Eberharter, Ther ...
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Dudas, Jozsef
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Rask-Andersen, H ...
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Hoermann, Romed
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visa fler...
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Fritsch, Helga
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Fischer, Natalie
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Glueckert, Rudol ...
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Schrott-Fischer, ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Cellbiologi
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MEDICIN OCH HÄLS ...
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Uppsala universitet