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Atopy Modifies the ...
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Marcon, AlessandroUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, Italy
(författare)
Atopy Modifies the Association Between Inhaled Corticosteroid Use and Lung Function Decline in Patients with Asthma
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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ELSEVIER,2020
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-408284
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-408284URI
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https://doi.org/10.1016/j.jaip.2019.10.023DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: Inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, but response to medication is variable. Patients with allergic inflammation generally show a better short-term response to ICSs; however, studies on predictors of long-term response are few. OBJECTIVE: To assess whether allergic sensitization can modify the association between ICS use and lung function decline over 20 years in adult asthma. METHODS: We used data from the 3 clinical examinations of the European Community Respiratory Health Survey. We measured ICS use (no use, and use for <1.3, 1.3-8, and >8 years) and FEV1 decline among subjects with asthma over the 2 periods between consecutive examinations. We conducted a cohort study combining data of the 2 periods (906 observations from 745 subjects) to assess whether the association between ICS use and FEV1 decline was modified by allergic sensitization (IgE > 0.35 kU/L for any of house-dust mite, timothy grass, cat, or Cladosporium). RESULTS: FEV1 decline was similar for non-ICS users, as well as ICS users for less than 1.3 years, with and without allergic sensitization. However, among subjects on ICSs for a longer period, sensitization was associated with an attenuated decline (P-interaction = .006): in the group treated for more than 8 years, FEV1 decline was on average 27 mL/y (95% CIBonferroni-adjusted, 11-42) lower for subjects with sensitization compared with nonsensitized subjects. CONCLUSIONS: Our study suggests that biomarkers of atopy can predict a more favorable long-term response to ICSs. Randomized controlled studies are needed to confirm these findings. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Marchetti, PierpaoloUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, Italy
(författare)
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Anto, Josep M.Inst Global Hlth ISGlobal, Barcelona, Spain;Univ Pompeu Fabra, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
(författare)
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Cazzoletti, LuciaUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, Italy
(författare)
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Cerveri, IsaUniv Pavia, IRCCS Policlin San Matteo Fdn, Dept Internal Med & Therapeut, Div Resp Dis, Pavia, Italy
(författare)
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Corsico, AngeloUniv Pavia, IRCCS Policlin San Matteo Fdn, Dept Internal Med & Therapeut, Div Resp Dis, Pavia, Italy
(författare)
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Ferreira, Diogenes SeraphimMonash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia;Univ Fed Parana, Complexo Hosp Clin, Alergia & Imunol, Curitiba, Parana, Brazil
(författare)
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Garcia-Aymerich, JudithInst Global Hlth ISGlobal, Barcelona, Spain;Univ Pompeu Fabra, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
(författare)
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Gislason, DavidLandspitali Univ Hosp, Dept Allergy Resp Med & Sleep, Reykjavik, Iceland
(författare)
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Heinrich, JoachimMaximilians Univ, Univ Hosp Ludwig, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany;German Ctr Lung Res, Comprehens Pneumol Ctr Munich, Munich, Germany
(författare)
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Jogi, RainUniv Tartu, Dept Pneumol, Tartu, Estonia
(författare)
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Johannessen, AneUniv Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway
(författare)
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Leynaert, BenedicteVIMA Aging & Chron Dis Epidemiol & Publ Hlth Appr, Inserm U1168, Villejuif, France;Univ Versailles St Quentin Yvelines, UMR S 1168, UVSQ, St Quentin En Yvelines, France
(författare)
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Malinovschi, Andrei,1978-Uppsala universitet,Klinisk fysiologi(Swepub:uu)anmal535
(författare)
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Pin, IsabelleCtr Hosp Univ Grenoble Alpes, Pediat, Grenoble, France;INSERM, Inst Adv Biosci, Grenoble, France;Univ Grenoble Alpes, Grenoble, France
(författare)
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Probst-Hensch, NicoleSwiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland;Univ Basel, Basel, Switzerland
(författare)
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Weyler, JoostUniv Antwerp, StatUA Stat Ctr, Epidemiol & Social Med, Antwerp, Belgium
(författare)
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Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn
(författare)
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Jarvis, DeborahImperial Coll London, Natl Heart & Lung Inst, London, England;Imperial Coll London, MRC, PHE, Ctr Environm & Hlth, London, England
(författare)
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Accordini, SimoneUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, Italy
(författare)
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Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, ItalyInst Global Hlth ISGlobal, Barcelona, Spain;Univ Pompeu Fabra, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Allergy and Clinical Immunology: ELSEVIER8:3, s. 980-+2213-21982213-2201
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Marcon, Alessand ...
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Marchetti, Pierp ...
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Anto, Josep M.
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Cazzoletti, Luci ...
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Cerveri, Isa
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Corsico, Angelo
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Ferreira, Diogen ...
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Garcia-Aymerich, ...
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Gislason, David
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Heinrich, Joachi ...
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Jogi, Rain
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Johannessen, Ane
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Leynaert, Benedi ...
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Malinovschi, And ...
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Pin, Isabelle
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Probst-Hensch, N ...
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Weyler, Joost
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Janson, Christer
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Jarvis, Deborah
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Accordini, Simon ...
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