SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Cerveri Isa)
 

Sökning: WFRF:(Cerveri Isa) > Atopy Modifies the ...

  • Marcon, AlessandroUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, Italy (författare)

Atopy Modifies the Association Between Inhaled Corticosteroid Use and Lung Function Decline in Patients with Asthma

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • ELSEVIER,2020
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-408284
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-408284URI
  • https://doi.org/10.1016/j.jaip.2019.10.023DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, but response to medication is variable. Patients with allergic inflammation generally show a better short-term response to ICSs; however, studies on predictors of long-term response are few. OBJECTIVE: To assess whether allergic sensitization can modify the association between ICS use and lung function decline over 20 years in adult asthma. METHODS: We used data from the 3 clinical examinations of the European Community Respiratory Health Survey. We measured ICS use (no use, and use for <1.3, 1.3-8, and >8 years) and FEV1 decline among subjects with asthma over the 2 periods between consecutive examinations. We conducted a cohort study combining data of the 2 periods (906 observations from 745 subjects) to assess whether the association between ICS use and FEV1 decline was modified by allergic sensitization (IgE > 0.35 kU/L for any of house-dust mite, timothy grass, cat, or Cladosporium). RESULTS: FEV1 decline was similar for non-ICS users, as well as ICS users for less than 1.3 years, with and without allergic sensitization. However, among subjects on ICSs for a longer period, sensitization was associated with an attenuated decline (P-interaction = .006): in the group treated for more than 8 years, FEV1 decline was on average 27 mL/y (95% CIBonferroni-adjusted, 11-42) lower for subjects with sensitization compared with nonsensitized subjects. CONCLUSIONS: Our study suggests that biomarkers of atopy can predict a more favorable long-term response to ICSs. Randomized controlled studies are needed to confirm these findings. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Marchetti, PierpaoloUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, Italy (författare)
  • Anto, Josep M.Inst Global Hlth ISGlobal, Barcelona, Spain;Univ Pompeu Fabra, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain (författare)
  • Cazzoletti, LuciaUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, Italy (författare)
  • Cerveri, IsaUniv Pavia, IRCCS Policlin San Matteo Fdn, Dept Internal Med & Therapeut, Div Resp Dis, Pavia, Italy (författare)
  • Corsico, AngeloUniv Pavia, IRCCS Policlin San Matteo Fdn, Dept Internal Med & Therapeut, Div Resp Dis, Pavia, Italy (författare)
  • Ferreira, Diogenes SeraphimMonash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia;Univ Fed Parana, Complexo Hosp Clin, Alergia & Imunol, Curitiba, Parana, Brazil (författare)
  • Garcia-Aymerich, JudithInst Global Hlth ISGlobal, Barcelona, Spain;Univ Pompeu Fabra, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain (författare)
  • Gislason, DavidLandspitali Univ Hosp, Dept Allergy Resp Med & Sleep, Reykjavik, Iceland (författare)
  • Heinrich, JoachimMaximilians Univ, Univ Hosp Ludwig, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany;German Ctr Lung Res, Comprehens Pneumol Ctr Munich, Munich, Germany (författare)
  • Jogi, RainUniv Tartu, Dept Pneumol, Tartu, Estonia (författare)
  • Johannessen, AneUniv Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway (författare)
  • Leynaert, BenedicteVIMA Aging & Chron Dis Epidemiol & Publ Hlth Appr, Inserm U1168, Villejuif, France;Univ Versailles St Quentin Yvelines, UMR S 1168, UVSQ, St Quentin En Yvelines, France (författare)
  • Malinovschi, Andrei,1978-Uppsala universitet,Klinisk fysiologi(Swepub:uu)anmal535 (författare)
  • Pin, IsabelleCtr Hosp Univ Grenoble Alpes, Pediat, Grenoble, France;INSERM, Inst Adv Biosci, Grenoble, France;Univ Grenoble Alpes, Grenoble, France (författare)
  • Probst-Hensch, NicoleSwiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland;Univ Basel, Basel, Switzerland (författare)
  • Weyler, JoostUniv Antwerp, StatUA Stat Ctr, Epidemiol & Social Med, Antwerp, Belgium (författare)
  • Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn (författare)
  • Jarvis, DeborahImperial Coll London, Natl Heart & Lung Inst, London, England;Imperial Coll London, MRC, PHE, Ctr Environm & Hlth, London, England (författare)
  • Accordini, SimoneUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, Italy (författare)
  • Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, C O Ist Biol 2,Str Le Grazie 8, I-37134 Verona, ItalyInst Global Hlth ISGlobal, Barcelona, Spain;Univ Pompeu Fabra, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Allergy and Clinical Immunology: ELSEVIER8:3, s. 980-+2213-21982213-2201

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy