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Prostate cancer mor...
Prostate cancer mortality and metastasis under different biopsy frequencies in North American active surveillance cohorts
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- Lange, Jane M. (författare)
- Fred Hutchinson Canc Res Ctr, Dept Biostat, Seattle, WA 98102 USA
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- Laviana, Aaron A. (författare)
- Vanderbilt Univ, Vanderbilt Ctr Hlth Serv Res, 221 Kirkland Hall, Nashville, TN 37235 USA
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- Penson, David F. (författare)
- Vanderbilt Univ, Dept Urol Surg, 221 Kirkland Hall, Nashville, TN 37235 USA;Vanderbilt Univ, Dept Hlth Policy, 221 Kirkland Hall, Nashville, TN 37235 USA
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- Lin, Daniel W. (författare)
- Univ Washington, Dept Urol, Seattle, WA 98195 USA
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- Bill-Axelson, Anna (författare)
- Uppsala universitet,Urologkirurgi
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- Carlsson, Sigrid, 1982 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Newcomb, Lisa F. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
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- Trock, Bruce J. (författare)
- Johns Hopkins Univ, Brady Urol Inst, Baltimore, MD USA
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- Carter, H. Ballentine (författare)
- Johns Hopkins Med, Dept Urol, Baltimore, MD USA
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- Carroll, Peter R. (författare)
- Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA
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- Cooperberg, Mathew R. (författare)
- Univ Calif San Francisco, Dept Urol, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA
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- Cowan, Janet E. (författare)
- Univ Calif San Francisco, Mission Bay Lib, San Francisco, CA 94143 USA
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- Klotz, Laurence H. (författare)
- Univ Toronto, Dept Urol, Toronto, ON, Canada
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- Etzioni, Ruth B. (författare)
- Fred Hutchinson Canc Res Ctr, Dept Biostat, Seattle, WA 98102 USA;Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA
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(creator_code:org_t)
- 2019-10-22
- 2020
- Engelska.
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Ingår i: Cancer. - : WILEY. - 0008-543X .- 1097-0142. ; 126:3, s. 583-592
- Relaterad länk:
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https://acsjournals....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Background Active surveillance (AS) is an accepted means of managing low-risk prostate cancer. Because of the rarity of downstream events, data from existing AS cohorts cannot yet address how differences in surveillance intensity affect metastasis and mortality. This study projected the comparative benefits of different AS schedules in men diagnosed with prostate cancer who had Gleason score (GS) <= 6 disease and risk profiles similar to those in North American AS cohorts. Methods Times of GS upgrading were simulated based on AS data from the University of Toronto, Johns Hopkins University, the University of California at San Francisco, and the Canary Pass Active Surveillance Cohort. Times to metastasis and prostate cancer death, informed by models from the Scandinavian Prostate Cancer Group 4 trial, were projected under biopsy surveillance schedules ranging from watchful waiting to annual biopsies. Outcomes included the risk of metastasis, the risk of death, remaining life-years (LYs), and quality-adjusted LYs. Results Compared with watchful waiting, AS biopsies reduced the risk of prostate cancer metastasis and prostate cancer death at 20 years by 1.4% to 3.3% and 1.0% to 2.4%, respectively; and 5-year biopsies reduced the risk of metastasis and prostate cancer death by 1.0% to 2.4% and 0.6% to 1.6%, respectively. There was little difference between annual and 5-year biopsy schedules in terms of LYs (range of differences, 0.04-0.16 LYs) and quality-adjusted LYs (range of differences, -0.02 to 0.09 quality-adjusted LYs). Conclusions Among men diagnosed with GS <= 6 prostate cancer, obtaining a biopsy every 3 or 4 years appears to be an acceptable alternative to more frequent biopsies. Reducing surveillance intensity for those who have a low risk of progression reduces the number of biopsies while preserving the benefit of more frequent schedules.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- active surveillance
- biopsy
- Gleason score
- microsimulation
- prostate cancer
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Cancer
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Till lärosätets databas
- Av författaren/redakt...
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Lange, Jane M.
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Laviana, Aaron A ...
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Penson, David F.
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Lin, Daniel W.
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Bill-Axelson, An ...
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Carlsson, Sigrid ...
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visa fler...
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Newcomb, Lisa F.
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Trock, Bruce J.
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Carter, H. Balle ...
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Carroll, Peter R ...
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Cooperberg, Math ...
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Cowan, Janet E.
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Klotz, Laurence ...
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Etzioni, Ruth B.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Cancer
- Av lärosätet
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Uppsala universitet
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Göteborgs universitet