A nutrition intervention in men with prostate cancer: Exploring effects on bowel symptoms from radiotherapy, patient experience, and nutrient intake

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Forslund, MarinaUppsala universitet,Institutionen för immunologi, genetik och patologi,Birgitta Johansson (author)

A nutrition intervention in men with prostate cancer : Exploring effects on bowel symptoms from radiotherapy, patient experience, and nutrient intake

BookEnglish2020

Publisher, publication year, extent ...

Uppsala :Acta Universitatis Upsaliensis,2020
83 s.
electronicrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-408823
ISBN:9789151309453
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-408823URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:vet swepub-contenttype
Subject category:dok swepub-publicationtype

Series

Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,1651-6206 ;1666

Notes

Objective The main objective of this thesis was to explore the effects of a nutrition intervention on acute and late bowel symptoms in men with localised prostate cancer treated with pelvic radiotherapy (study I), participants’ experiences from receiving the nutrition intervention (study II), and associations with nutrient intakes (study III).Methods A total of 180 men with localised prostate cancer referred to curative radiotherapy targeting the prostate gland and pelvic lymph nodes were recruited to the trial. The participants were randomised to standard care plus a nutrition intervention aiming to modify fibre and lactose intakes (NIG; n=92) or standard care alone (SCG; n=88). Data on bowel symptoms and dietary intake were collected pre-treatment and at seven time points during a 26-month study period. Analyses of the effects of the nutrition intervention on bowel symptoms were conducted for the acute phase (up to 2 months post radiotherapy), and the late phase (7 to 24 months post radiotherapy). Semi-structured interviews were conducted with 15 participants from the NIG to explore experiences of the nutrition intervention.Results The nutrition intervention was associated with statistically significantly, but not clinically significantly, less bother from blood in stools and flatulence during the acute phase. The nutrition intervention was also associated with more bloated abdomen during the late phase (Study I). Social support, contributing to the greater good, prior knowledge, dietary information, and a small need for change facilitated adherence. While feeling limited, wanting to decide for themselves, the timing of the intervention, unmet expectations, and loss of motivation were described as barriers for adherence (Study II). A greater reduction of lactose was associated with decreased intake of calcium at the end of the radiotherapy period. A more modified fibre intake during the radiotherapy period was associated with increased vitamin C, but decreased selenium intake (Study III).Conclusions The effects from the nutrition intervention were small and inconclusive and do not support routine dietary advice aiming to modify fibre and lactose intakes as a mean to substantially reduce adverse effects from pelvic radiotherapy. Tailored nutritional interventions based on individual preferences, prior knowledge, and context, could enhance adherence. There were few associations between modified fibre and lactose intakes and nutrient intakes, thus, no recommendations can be made on whether such dietary advice should continue to be provided to men with prostate cancer undergoing pelvic radiotherapy.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Omvårdnad hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nursing hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Näringslära hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nutrition and Dietetics hsv//eng
Nutrition intervention
bowel symptoms
radiotherapy
prostate cancer
Caring Sciences
Vårdvetenskap
Nutrition
Nutrition

Added entries (persons, corporate bodies, meetings, titles ...)

Johansson, Birgitta,DocentUppsala universitet,Institutionen för immunologi, genetik och patologi (thesis advisor)
Nygren, Peter,ProfessorUppsala universitet,Institutionen för immunologi, genetik och patologi (thesis advisor)
Ottenblad, Anna,Medicine doktorDepartment of Nutrition and Dietetics, Karolinska University Hospital, Stockholm, Sweden (thesis advisor)
Winkvist, Anna,ProfessorDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg (opponent)
Uppsala universitetInstitutionen för immunologi, genetik och patologi (creator_code:org_t)

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