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Associations betwee...
Associations between pretherapeutic body mass index, outcome, and cytogenetic abnormalities in pediatric acute myeloid leukemia
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- Löhmann, Ditte J. A. (author)
- Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
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- Asdahl, Peter H. (author)
- Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
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- Abrahamsson, Jonas (author)
- Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden
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- Ha, Shau-Yin (author)
- Queen Mary Hosp, Dept Pediat, Hong Kong, Peoples R China;HKPHOSG, Hong Kong, Peoples R China
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- Jonsson, Olafur G. (author)
- Landspitali Univ Hosp, Dept Pediat, Reykjavik, Iceland
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- Kaspers, Gertjan J. L. (author)
- Vrije Univ Amsterdam Med Ctr, Dept Pediat, Amsterdam, Netherlands;Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands;Dutch Childhood Oncol Grp, The Hague, Netherlands
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- Koskenvuo, Minna (author)
- Childrens Hosp, Div Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland;Helsinki Univ Cent Hosp, Helsinki, Finland
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- Lausen, Birgitte (author)
- Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark
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- De Moerloose, Barbara (author)
- Ghent Univ Hosp, Dept Pediat, Ghent, Belgium
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- Palle, Josefine, 1964- (author)
- Uppsala universitet,Barnneurologi/Barnonkologi
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- Zeller, Bernward (author)
- Oslo Univ Hosp, Div Pediat & Adolescent Med, Oslo, Norway
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- Sung, Lillian (author)
- Hosp Sick Children, Div Hematol Oncol, Toronto, ON, Canada
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- Hasle, Henrik (author)
- Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
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(creator_code:org_t)
- 2019-09-18
- 2019
- English.
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In: Cancer Medicine. - : WILEY. - 2045-7634. ; 8:15, s. 6634-6643
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Abstract
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- Background: Associations between body mass index (BMI), outcome, and leukemia-related factors in children with acute myeloid leukemia (AML) remain unclear. We investigated associations between pretherapeutic BMI, cytogenetic abnormalities, and outcome in a large multinational cohort of children with AML.Methods: We included patients, age 2-17 years, diagnosed with de novo AML from the five Nordic countries (2004-2016), Hong Kong (2007-2016), the Netherlands and Belgium (2010-2016), and Canada and USA (1995-2012). BMI standard deviations score for age and sex was calculated and categorized according to the World Health Organization. Cumulative incidence functions, Kaplan-Meier estimator, Cox regression, and logistic regression were used to investigate associations.Results: In total, 867 patients were included. The median age was 10 years (range 2-17 years). At diagnosis, 32 (4%) were underweight, 632 (73%) were healthy weight, 127 (15%) were overweight, and 76 (9%) were obese. There was no difference in relapse risk, treatment-related mortality or overall mortality across BMI groups. The frequency of t(8;21) and inv(16) increased with increasing BMI. For obese patients, the sex, age, and country adjusted odds ratio of having t(8;21) or inv(16) were 1.9 (95% confidence interval (CI) 1.1-3.4) and 2.8 (95% CI 1.3-5.8), respectively, compared to healthy weight patients.Conclusions: This study did not confirm previous reports of associations between overweight and increased treatment-related or overall mortality in children. Obesity was associated with a higher frequency of t(8;21) and inv(16). AML cytogenetics appear to differ by BMI status.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- acute myeloid leukemia
- body mass index
- cytogenetic aberrations
- mortality
- pediatrics
- recurrence
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Löhmann, Ditte J ...
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Asdahl, Peter H.
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Abrahamsson, Jon ...
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Ha, Shau-Yin
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Jonsson, Olafur ...
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Kaspers, Gertjan ...
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Koskenvuo, Minna
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Lausen, Birgitte
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De Moerloose, Ba ...
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Palle, Josefine, ...
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Zeller, Bernward
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Sung, Lillian
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Hasle, Henrik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Medicine
- By the university
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Uppsala University