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Inclusion of Endoge...
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Gabrielson, MarikeKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
(författare)
Inclusion of Endogenous Plasma Dehydroepiandrosterone Sulfate and Mammographic Density in Risk Prediction Models for Breast Cancer
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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American Association For Cancer Research (AACR),2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-408929
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-408929URI
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https://doi.org/10.1158/1055-9965.EPI-19-1120DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143272341URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background: Endogenous hormones and mammographic density are risk factors for breast cancer. Joint analyses of the two may improve the ability to identify high-risk women.Methods: This study within the KARMA cohort included pre-diagnostic measures of plasma hormone levels of dehydroepiandrosterone (DHEA), its sulfate (DHEAS), and mammographic density in 629 cases and 1,223 controls, not using menopausal hormones. We evaluated the area under the receiver-operating curve (AUC) for risk of breast cancer by adding DHEA, DHEAS, and mammographic density to the Gail or Tyrer-Cuzick 5-year risk scores or the CAD2Y 2-year risk score.Results: DHEAS and percentage density were independently and positively associated with breast cancer risk (P = 0.007 and P < 0.001, respectively) for postmenopausal, but not premenopausal, women. No significant association was seen for DHEA. In postmenopausal women, those in the highest tertiles of both DHEAS and density were at greatest risk of breast cancer (OR, 3.5; 95% confidence interval, 1.9-6.3) compared with the lowest tertiles. Adding DHEAS significantly improved the AUC for the Gail (+2.1 units, P = 0.008) and Tyrer-Cuzick (+1.3 units, P = 0.007) risk models. Adding DHEAS to the Gail and Tyrer-Cuzick models already including mammographic density further increased the AUC by 1.2 units (P = 0.006) and 0.4 units (P = 0.007), respectively, compared with only including density.Conclusions: DHEAS and mammographic density are independent risk factors for breast cancer and improve risk discrimination for postmenopausal breast cancer.Impact: Combining DHEAS and mammographic density could help identify women at high risk who may benefit from individualized breast cancer screening and/or preventive measures among postmenopausal women.
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Ubhayasekera, KumariUppsala universitet,Analytisk kemi(Swepub:uu)kumub884
(författare)
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Acharya, Santosh R.Uppsala universitet,Analytisk kemi
(författare)
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Franko, Mikael AnderssonKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
(författare)
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Eriksson, MikaelKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
(författare)
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Bergquist, JonasUppsala universitet,Analytisk kemi(Swepub:uu)jbe25356
(författare)
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Czene, KamilaKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
(författare)
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Hall, PerKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;South Gen Hosp, Dept Oncol, Stockholm, Sweden
(författare)
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Karolinska InstitutetKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cancer Epidemiology, Biomarkers and Prevention: American Association For Cancer Research (AACR)29:3, s. 574-5811055-99651538-7755
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