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  • Bjerre, MetteMedical Research Laboratory, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark (författare)

Serum osteoprotegerin as a long-term predictor for patients with stable coronary artery disease and its association with diabetes and statin treatment : A CLARICOR trial 10-year follow-up substudy

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-408980
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-408980URI
  • https://doi.org/10.1016/j.atherosclerosis.2020.03.030DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143840980URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:du-32636URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND AND AIMS: Elevated circulating levels of osteoprotegerin (OPG) are known to add to the prediction of cardiovascular mortality. Our objective was to clarify the long-term risk associated with serum OPG and the possible influence of diabetes and statins on OPG levels in patients with stable coronary artery disease (CAD).METHODS: We assessed the placebo-treated group (n = 1998) from the CLARICOR trial (NCT00121550), a cohort with stable CAD. At entry, 15% of the participants had diabetes and 41% received statins. Serum OPG levels were measured in blood drawn at randomization. Participants were followed through public registers for 10 years.RESULTS: OPG levels correlated positively with diabetes status, age, CRP and female sex, but negatively with the use of statins. CAD participants with diabetes had significantly elevated serum OPG levels compared to participants without diabetes, p < 0.0001. The participants without diabetes treated with statins presented with significantly lower serum OPG levels than the corresponding non-statin-users (p < 0.0001). However, statin use showed no association with OPG levels in the participants with diabetes. High OPG levels at entry showed long-term associations with all-cause mortality and cardiovascular events (hazard ratio associated with factor 10 OPG increase 15.9 (95% CI 11.0-22.9) and 6.38 (4.60-8.90), p = 0.0001, even after adjustment for standard predictors (3.16 (1.90-5.25) and 2.29 (1.53-3.44), p < 0.0001).CONCLUSIONS: Circulating OPG holds long-term independent predictive ability for all-cause mortality and cardiovascular events in CAD participants. OPG levels were associated with diabetes, age, and female sex and statin treatment was associated with lower OPG levels in the absence of diabetes.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hilden, JørgenDepartment of Biostatistics, Institute of Public Health Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
  • Winkel, PerThe Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark (författare)
  • Jensen, Gorm BojeDepartment of Cardiology, Hvidovre Hospital, Copenhagen University Hospital, Copenhagen, Denmark (författare)
  • Kjøller, ErikThe Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital; Department of Cardiology, S, Herlev Hospital, University of Copenhagen (författare)
  • Sajadieh, AhmadDepartment of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark (författare)
  • Kastrup, JensDepartment of Cardiology, Rigshospitalet University of Copenhagen, Denmark (författare)
  • Kolmos, Hans JørnDepartment of Clinical Microbiology, Odense University Hospital, Denmark (författare)
  • Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andlarss (författare)
  • Ärnlöv, Johan,1970-Högskolan Dalarna,Karolinska Institutet,Medicinsk vetenskap,Karolinska Institute(Swepub:du)jan (författare)
  • Jakobsen, Janus ChristianThe Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Cardiology, Holbæk Hospital, Holbæk, Denmark; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern, Denmark (författare)
  • Gluud, ChristianThe Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark (författare)
  • Medical Research Laboratory, Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkDepartment of Biostatistics, Institute of Public Health Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Atherosclerosis: Elsevier BV301, s. 8-140021-91501879-1484

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