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  • Saidi, TarikMoulay Ismail Univ Meknes, Fac Sci, Dept Phys, Sensor Elect & Instrumentat Grp, BP 11201, Zitoune, Meknes, Morocco.;Moulay Ismail Univ Meknes, Fac Sci, Dept Phys, Biotechnol Agroalimentary & Biomed Anal Grp, BP 11201, Zitoune, Meknes, Morocco. (författare)

Non-invasive prediction of lung cancer histological types through exhaled breath analysis by UV-irradiated electronic nose and GC/QTOF/MS

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-409702
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409702URI
  • https://doi.org/10.1016/j.snb.2020.127932DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Lung cancer (LC) is one of the most lethal diseases from the last decades. Accurate diagnosis of LC histology could lead to the prescription of personalized medical treatment to the affected subjects, which could reduce the mortality rate. We present here an experimental study performed in the pulmonology units of three hospitals from Morocco to non-invasively detect LC and predict LC histology via the analysis of the volatile organic compounds (VOCs) emitted through breathing. Gas chromatography coupled to a quadrupole time-of-flight mass spectrometer (GC/QTOF/MS) employed to detect the breath VOCs, revealed 30 discriminative VOCs in the breath of healthy subjects and LC patients; among them, 4 unique breath VOCs were found for the first time in the breath of LC patients, and could be used as new biomarkers for future LC diagnosis. Besides, an electronic nose (e-nose) system using a novel sensing technique in breath analysis, based on UV-irradiation of the gas sensors, was employed to characterize the overall composition of the collected breath samples, providing a satisfactory discrimination between the breath patterns of LC patients and healthy subjects. Importantly, the e-nose could further discriminate with high accuracy between the two types of LC (non-small cell LC and small cell LC), as well as between two of the major subtypes of non-small cell LC, namely squamous cell carcinoma (SCC) and adenocarcinoma (ADC). The reported results prove that breath analysis with chemical gas sensors and analytical techniques can provided an accurate mean for the non-invasive diagnosis of LC and LC histology.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Moufid, MohammedMoulay Ismail Univ Meknes, Fac Sci, Dept Phys, Sensor Elect & Instrumentat Grp, BP 11201, Zitoune, Meknes, Morocco.;Moulay Ismail Univ Meknes, Fac Sci, Dept Phys, Biotechnol Agroalimentary & Biomed Anal Grp, BP 11201, Zitoune, Meknes, Morocco. (författare)
  • de Jesus Beleno-Saenz, KelvinUniv Autonoma Caribe, Mechatron Engn Dept, Barranquilla, Colombia.;Univ Complutense Madrid, Dept Chem Engn, Madrid 28040, Spain. (författare)
  • Welearegay, Tesfalem GeremariamUppsala universitet,Fasta tillståndets fysik,Rovira & Virgili Univ, Dept Elect Elect & Automat Engn, Av Paisos Catalans 26, Tarragona 43007, Spain (författare)
  • El Bari, NezhaMoulay Ismail Univ Meknes, Fac Sci, Dept Phys, Biotechnol Agroalimentary & Biomed Anal Grp, BP 11201, Zitoune, Meknes, Morocco. (författare)
  • Lisset Jaimes-Mogollon, AylenUniv Complutense Madrid, Dept Chem Engn, Madrid 28040, Spain.;Univ Pamplona, Fac Engn & Architecture, GISM Grp, Pamplona, Colombia. (författare)
  • Ionescu, RaduUppsala universitet,Fasta tillståndets fysik(Swepub:uu)radio285 (författare)
  • Bourkadi, Jamal EddineUniv Mohammed 5, Moulay Youssef Univ Hosp, Resp Dept, Rabat 10000, Morocco. (författare)
  • Benamor, JoudaUniv Mohammed 5, Moulay Youssef Univ Hosp, Resp Dept, Rabat 10000, Morocco. (författare)
  • El Ftouh, MustaphaInt Univ Rabat, Avicenna Univ Hosp, Pulm Unit, BP 6527, Rabat, Morocco. (författare)
  • Bouchikhi, BenachirMoulay Ismail Univ Meknes, Fac Sci, Dept Phys, Sensor Elect & Instrumentat Grp, BP 11201, Zitoune, Meknes, Morocco. (författare)
  • Moulay Ismail Univ Meknes, Fac Sci, Dept Phys, Sensor Elect & Instrumentat Grp, BP 11201, Zitoune, Meknes, Morocco.;Moulay Ismail Univ Meknes, Fac Sci, Dept Phys, Biotechnol Agroalimentary & Biomed Anal Grp, BP 11201, Zitoune, Meknes, Morocco.Univ Autonoma Caribe, Mechatron Engn Dept, Barranquilla, Colombia.;Univ Complutense Madrid, Dept Chem Engn, Madrid 28040, Spain. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Sensors and actuators. B, Chemical: Elsevier BV3110925-40051873-3077

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