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Sökning: (WFRF:(Quertermous Thomas)) pers:(Knowles Joshua W.) > (2020-2023) > FAM13A affects body...

FAM13A affects body fat distribution and adipocyte function

Fathzadeh, Mohsen (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.
Li, Jiehan (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.
Rao, Abhiram (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Sch Engn & Med, Bioengn Dept, Stanford, CA USA.
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Cook, Naomi L. (författare)
Uppsala universitet,Molekylär epidemiologi
Chennamsetty, Indumathi (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.
Seldin, Marcus (författare)
UCLA, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA.
Zhou, Xiang (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.
Sangwung, Panjamaporn (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.
Gloudemans, Michael J. (författare)
Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
Keller, Mark (författare)
Univ Wisconsin, Dept Biochem, 420 Henry Mall, Madison, WI 53705 USA.
Attie, Allan (författare)
Univ Wisconsin, Dept Biochem, 420 Henry Mall, Madison, WI 53705 USA.
Yang, Jing (författare)
Univ Illinois, Coll Vet Med, Dept Comparat Biosci, Urbana, IL USA.
Wabitsch, Martin (författare)
Univ Ulm, Dept Paediat & Adolescent Med, Div Paediat Endocrinol & Diabet, Ulm, Germany.
Carcamo-Orive, Ivan (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.
Tada, Yuko (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.
Lusis, Aldons J. (författare)
UCLA, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA.
Shin, Myung Kyun (författare)
Merck & Co Inc, Genet & Pharmacogen, Kenilworth, NJ USA.
Molony, Cliona M. (författare)
Merck & Co Inc, Genet & Pharmacogen, Kenilworth, NJ USA.
McLaughlin, Tracey (författare)
Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.;Stanford Univ, Dept Med, Sch Med, Div Endocrinol, Stanford, CA 94305 USA.
Reaven, Gerald (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.
Montgomery, Stephen B. (författare)
Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.;Stanford Univ, Dept Genet, Stanford, CA 94305 USA.;Stanford Univ, Dept Med, Sch Med, Div Endocrinol, Stanford, CA 94305 USA.;Stanford Univ, Dept Pathol, Stanford, CA 94305 USA.
Reilly, Dermot (författare)
Merck & Co Inc, Genet & Pharmacogen, Kenilworth, NJ USA.
Quertermous, Thomas (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.
Ingelsson, Erik (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.
Knowles, Joshua W. (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.
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Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA. Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Sch Engn & Med, Bioengn Dept, Stanford, CA USA. (creator_code:org_t)
2020-03-19
2020
Engelska.
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://www.nature.c...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of FAM13A in preadipocytes accelerates adipocyte differentiation. In mice, Fam13a knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge, in comparison to their wild-type counterparts. Subcutaneous adipocytes in KO mice show a size distribution shift toward an increased number of smaller adipocytes, along with an improved adipogenic potential. Our results indicate that GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution. Genetic variants in the FAM13A locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in pre-adipocytes and in vivo knockout in mice, the authors show that FAM13A is involved in regulating fat distribution and metabolic traits.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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