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Late effects after ...
Late effects after ablative allogeneic stem cell transplantation for adolescent and young adult acute myeloid leukemia
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- Lee, Catherine J. (author)
- Univ Utah, Huntsman Canc Inst, Utah Blood & Marrow Transplant Program, 2000 Circle Hope,Room 2152, Salt Lake City, UT 84112 USA.
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- Kim, Soyoung (author)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Heath & Equ, Div Biostat, Milwaukee, WI 53226 USA.
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- Tecca, Heather R. (author)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.
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- Bo-Subait, Stephanie (author)
- Natl Marrow Donor Program Be Match, CIBMTR, Minneapolis, MN USA.
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- Phelan, Rachel (author)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.
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- Brazauskas, Ruta (author)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Heath & Equ, Div Biostat, Milwaukee, WI 53226 USA.
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- Buchbinder, David (author)
- Childrens Hosp Orange Cty, Div Pediat Hematol, Orange, CA 92668 USA.
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- Hamilton, Betty K. (author)
- Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA.
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- Battiwalla, Minoo (author)
- Sarah Cannon Bone Marrow Transplant Program, Hematol Branch, Nashville, TN USA.
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- Majhail, Navneet S. (author)
- Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA.
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- Lazarus, Hillard M. (author)
- Case Western Reserve Univ, Univ Hosp Case Med Ctr, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA.
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- Shaw, Peter J. (author)
- Childrens Hosp Westmead, Westmead, NSW, Australia.
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- Marks, David, I (author)
- Univ Hosp Bristol Natl Hlth Serv Trust, Adult Bone Marrow Transplant, Bristol, Avon, England.
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- Litzow, Mark R. (author)
- Mayo Clin, Div Hematol & Transplant Ctr, Rochester, MN USA.
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- Chhabra, Saurabh (author)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.
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- Inamoto, Yoshihiro (author)
- Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.
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- DeFilipp, Zachariah (author)
- Massachusetts Gen Hosp, Blood & Marrow Transplant Program, Boston, MA 02114 USA.
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- Hildebrandt, Gerhard C. (author)
- Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.
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- Olsson, Richard (author)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden
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- Kasow, Kimberly A. (author)
- Univ N Carolina, Pediat Hematol Oncol & Bone Marrow & Stem Cell Tr, Chapel Hill, NC 27515 USA.
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- Liesveld, Jane L. (author)
- Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA.
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- Rotz, Seth J. (author)
- Cleveland Clin Childrens Hosp, Dept Pediat Hematol Oncol & Blood & Marrow Transp, Cleveland, OH USA.
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- Badawy, Sherif M. (author)
- Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, Chicago, IL 60611 USA.;Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA.
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- Bhatt, Neel S. (author)
- Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
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- Yared, Jean A. (author)
- Univ Maryland, Dept Med, Greenebaum Comprehens Canc Ctr, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA.
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- Page, Kristin M. (author)
- Duke Univ, Med Ctr, Div Pediat Blood & Marrow Transplantat, Durham, NC USA.
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- Arellano, Martha L. (author)
- Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA.
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- Kent, Michael (author)
- Levine Childrens Hosp, Charlotte, NC USA.
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- Farhadfar, Nosha (author)
- Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA.
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- Seo, Sachiko (author)
- Dokkyo Med Univ, Dept Haematol & Oncol, Mibu, Tochigi, Japan.
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- Hematti, Peiman (author)
- Univ Wisconsin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI USA.
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- Freytes, Cesar O. (author)
- Texas Transplant Inst, San Antonio, TX USA.
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- Rovo, Alicia (author)
- Univ Spital Bern, Inselspital, Bern, Switzerland.
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- Ganguly, Siddhartha (author)
- Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA.
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- Nathan, Sunita (author)
- Rush Univ, Med Ctr, Chicago, IL 60612 USA.
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- Burns, Linda (author)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.
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- Shaw, Bronwen E. (author)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.
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- Muffly, Lori S. (author)
- Stanford Univ, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA.
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Univ Utah, Huntsman Canc Inst, Utah Blood & Marrow Transplant Program, 2000 Circle Hope,Room 2152, Salt Lake City, UT 84112 USA Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Heath & Equ, Div Biostat, Milwaukee, WI 53226 USA. (creator_code:org_t)
- 2020-03-13
- 2020
- English.
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In: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 4:6, s. 983-992
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- There is marked paucity of data regarding late effects in adolescents and young adults (AYAs) who undergo myeloablative conditioning (MAC) allogeneic hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML). We evaluated late effects and survival in 826 1-year disease-free survivors of MAC HCT for AYA AML, with an additional focus on comparing late effects based upon MAC type (total body irradiation [TBI] vs high-dose chemotherapy only). The estimated 10-year cumulative incidence of subsequent neoplasms was 4% (95% confidence interval [CI], 2%-6%); 10-year cumulative incidence of nonmalignant late effects included gonadal dysfunction (10%; 95% CI, 8%-13%), cataracts (10%; 95% CI, 7%-13%), avascular necrosis (8%; 95% CI, 5%-10%), diabetes mellitus (5%; 95% CI, 3%-7%), and hypothyroidism (3%; 95% CI, 2%-5%). Receipt of TBI was independently associated with a higher risk of cataracts only (hazard ratio [HR], 4.98; P < .0001) whereas chronic graft-versus-host disease (cGVHD) was associated with an increased risk of cataracts (HR, 3.22; P = .0006), avascular necrosis (HR, 2.49; P = .006), and diabetes mellitus (HR, 3.36; P = .03). Estimated 10-year overall survival and leukemia-free survival were 73% and 70%, respectively, and did not differ on the basis of conditioning type. In conclusion, late effects among survivors of MAC HCT for AYA AML are frequent and are more closely linked to cGVHD than type of conditioning.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lee, Catherine J ...
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Kim, Soyoung
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Tecca, Heather R ...
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Bo-Subait, Steph ...
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Phelan, Rachel
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Brazauskas, Ruta
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show more...
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Buchbinder, Davi ...
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Hamilton, Betty ...
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Battiwalla, Mino ...
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Majhail, Navneet ...
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Lazarus, Hillard ...
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Shaw, Peter J.
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Marks, David, I
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Litzow, Mark R.
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Chhabra, Saurabh
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Inamoto, Yoshihi ...
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DeFilipp, Zachar ...
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Hildebrandt, Ger ...
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Olsson, Richard
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Kasow, Kimberly ...
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Liesveld, Jane L ...
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Rotz, Seth J.
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Badawy, Sherif M ...
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Bhatt, Neel S.
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Yared, Jean A.
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Page, Kristin M.
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Arellano, Martha ...
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Kent, Michael
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Farhadfar, Nosha
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Seo, Sachiko
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Hematti, Peiman
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Freytes, Cesar O ...
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Rovo, Alicia
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Ganguly, Siddhar ...
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Nathan, Sunita
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Burns, Linda
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Shaw, Bronwen E.
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Muffly, Lori S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood Advances
- By the university
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Uppsala University
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Karolinska Institutet