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Amount and Intensit...
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Matthews, Charles E.NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
(author)
Amount and Intensity of Leisure-Time Physical Activity and Lower Cancer Risk
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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AMER SOC CLINICAL ONCOLOGY,2020
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-409789
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409789URI
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https://doi.org/10.1200/JCO.19.02407DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143285709URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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PURPOSE: To determine whether recommended amounts of leisure-time physical activity (ie, 7.5-15 metabolic equivalent task [MET] hours/week) are associated with lower cancer risk, describe the shape of the dose-response relationship, and explore associations with moderate- and vigorous-intensity physical activity.METHODS: Data from 9 prospective cohorts with self-reported leisure-time physical activity and follow-up for cancer incidence were pooled. Multivariable Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% CIs of the relationships between physical activity with incidence of 15 types of cancer. Dose-response relationships were modeled with restricted cubic spline functions that compared 7.5, 15.0, 22.5, and 30.0 MET hours/week to no leisure-time physical activity, and statistically significant associations were determined using tests for trend (P < .05) and 95% CIs (< 1.0).RESULTS: A total of 755,459 participants (median age, 62 years [range, 32-91 years]; 53% female) were followed for 10.1 years, and 50,620 incident cancers accrued. Engagement in recommended amounts of activity (7.5-15 MET hours/week) was associated with a statistically significant lower risk of 7 of the 15 cancer types studied, including colon (8%-14% lower risk in men), breast (6%-10% lower risk), endometrial (10%-18% lower risk), kidney (11%-17% lower risk), myeloma (14%-19% lower risk), liver (18%-27% lower risk), and non-Hodgkin lymphoma (11%-18% lower risk in women). The dose response was linear in shape for half of the associations and nonlinear for the others. Results for moderate- and vigorous-intensity leisure-time physical activity were mixed. Adjustment for body mass index eliminated the association with endometrial cancer but had limited effect on other cancer types.CONCLUSION: Health care providers, fitness professionals, and public health practitioners should encourage adults to adopt and maintain physical activity at recommended levels to lower risks of multiple cancers.
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Moore, Steven C.NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
(author)
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Arem, HannahGeorge Washington Univ, Sch Publ Hlth, Dept Epidemiol, Washington, DC USA
(author)
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Cook, Michael B.NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
(author)
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Trabert, BrittonNCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
(author)
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Håkansson, NiclasKarolinska Institutet
(author)
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Larsson, Susanna C.Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden(Swepub:uu)susla720
(author)
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Wolk, AlicjaKarolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden(Swepub:uu)alwol516
(author)
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Gapstur, Susan M.Amer Canc Soc, Behav & Epidemiol Res, Atlanta, GA 30329 USA
(author)
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Lynch, Brigid M.Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia;Baker Heart & Diabet Inst, Phys Act Lab, Melbourne, Vic, Australia
(author)
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Milne, Roger L.Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Melbourne, Vic, Australia
(author)
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Freedman, Neal D.NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
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Huang, Wen-YiNCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
(author)
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de Gonzalez, Amy BerringtonNCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD 20892 USA
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Kitahara, Cari M.NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD 20892 USA
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Linet, Martha S.Karolinska Institutet
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Shiroma, Eric J.NIA, Lab Epidemiol & Populat Sci, Baltimore, MD 21224 USA
(author)
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Sandin, SvenKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA;Seaver Autism Ctr Res & Treatment Mt Sinai, New York, NY USA
(author)
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Patel, Alpa, VAmer Canc Soc, Behav & Epidemiol Res, Atlanta, GA 30329 USA
(author)
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Lee, I-MinBrigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA
(author)
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NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USAGeorge Washington Univ, Sch Publ Hlth, Dept Epidemiol, Washington, DC USA
(creator_code:org_t)
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In:Journal of Clinical Oncology: AMER SOC CLINICAL ONCOLOGY38:7, s. 686-6970732-183X1527-7755
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Matthews, Charle ...
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Moore, Steven C.
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Arem, Hannah
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Cook, Michael B.
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Trabert, Britton
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Håkansson, Nicla ...
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Larsson, Susanna ...
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Wolk, Alicja
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Milne, Roger L.
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Freedman, Neal D ...
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Huang, Wen-Yi
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de Gonzalez, Amy ...
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Kitahara, Cari M ...
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Linet, Martha S.
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Shiroma, Eric J.
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Sandin, Sven
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Patel, Alpa, V
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Lee, I-Min
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