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  • Matthews, Charles E.NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA (author)

Amount and Intensity of Leisure-Time Physical Activity and Lower Cancer Risk

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • AMER SOC CLINICAL ONCOLOGY,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-409789
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409789URI
  • https://doi.org/10.1200/JCO.19.02407DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143285709URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • PURPOSE: To determine whether recommended amounts of leisure-time physical activity (ie, 7.5-15 metabolic equivalent task [MET] hours/week) are associated with lower cancer risk, describe the shape of the dose-response relationship, and explore associations with moderate- and vigorous-intensity physical activity.METHODS: Data from 9 prospective cohorts with self-reported leisure-time physical activity and follow-up for cancer incidence were pooled. Multivariable Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% CIs of the relationships between physical activity with incidence of 15 types of cancer. Dose-response relationships were modeled with restricted cubic spline functions that compared 7.5, 15.0, 22.5, and 30.0 MET hours/week to no leisure-time physical activity, and statistically significant associations were determined using tests for trend (P < .05) and 95% CIs (< 1.0).RESULTS: A total of 755,459 participants (median age, 62 years [range, 32-91 years]; 53% female) were followed for 10.1 years, and 50,620 incident cancers accrued. Engagement in recommended amounts of activity (7.5-15 MET hours/week) was associated with a statistically significant lower risk of 7 of the 15 cancer types studied, including colon (8%-14% lower risk in men), breast (6%-10% lower risk), endometrial (10%-18% lower risk), kidney (11%-17% lower risk), myeloma (14%-19% lower risk), liver (18%-27% lower risk), and non-Hodgkin lymphoma (11%-18% lower risk in women). The dose response was linear in shape for half of the associations and nonlinear for the others. Results for moderate- and vigorous-intensity leisure-time physical activity were mixed. Adjustment for body mass index eliminated the association with endometrial cancer but had limited effect on other cancer types.CONCLUSION: Health care providers, fitness professionals, and public health practitioners should encourage adults to adopt and maintain physical activity at recommended levels to lower risks of multiple cancers. 

Subject headings and genre

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  • Moore, Steven C.NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA (author)
  • Arem, HannahGeorge Washington Univ, Sch Publ Hlth, Dept Epidemiol, Washington, DC USA (author)
  • Cook, Michael B.NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA (author)
  • Trabert, BrittonNCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA (author)
  • Håkansson, NiclasKarolinska Institutet (author)
  • Larsson, Susanna C.Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden(Swepub:uu)susla720 (author)
  • Wolk, AlicjaKarolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden(Swepub:uu)alwol516 (author)
  • Gapstur, Susan M.Amer Canc Soc, Behav & Epidemiol Res, Atlanta, GA 30329 USA (author)
  • Lynch, Brigid M.Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia;Baker Heart & Diabet Inst, Phys Act Lab, Melbourne, Vic, Australia (author)
  • Milne, Roger L.Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Melbourne, Vic, Australia (author)
  • Freedman, Neal D.NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA (author)
  • Huang, Wen-YiNCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA (author)
  • de Gonzalez, Amy BerringtonNCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD 20892 USA (author)
  • Kitahara, Cari M.NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD 20892 USA (author)
  • Linet, Martha S.Karolinska Institutet (author)
  • Shiroma, Eric J.NIA, Lab Epidemiol & Populat Sci, Baltimore, MD 21224 USA (author)
  • Sandin, SvenKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA;Seaver Autism Ctr Res & Treatment Mt Sinai, New York, NY USA (author)
  • Patel, Alpa, VAmer Canc Soc, Behav & Epidemiol Res, Atlanta, GA 30329 USA (author)
  • Lee, I-MinBrigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA (author)
  • NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USAGeorge Washington Univ, Sch Publ Hlth, Dept Epidemiol, Washington, DC USA (creator_code:org_t)

Related titles

  • In:Journal of Clinical Oncology: AMER SOC CLINICAL ONCOLOGY38:7, s. 686-6970732-183X1527-7755

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