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Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups : a report of the Cooperative Weichteilsarkom Studiengruppe (CWS)

Scheer, Monika (författare)
Olga Hosp, Klinikum Stuttgart, Pediat Oncol Hematol Immunol 5, Kriegsbergstr 62, D-70174 Stuttgart, Germany
Blank, Bernd (författare)
Olga Hosp, Klinikum Stuttgart, Pediat Oncol Hematol Immunol 5, Kriegsbergstr 62, D-70174 Stuttgart, Germany
Bauer, Sebastian (författare)
Univ Duisburg Essen, Sarcoma Ctr, West German Canc Ctr, Essen, Germany
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Vokuhl, Christian (författare)
Univ Hosp Schleswig Holstein, Dept Paediat Pathol, Kiel Paediat Tumor Registry, Campus Kiel, Kiel, Germany
Stegmaier, Sabine (författare)
Olga Hosp, Klinikum Stuttgart, Pediat Oncol Hematol Immunol 5, Kriegsbergstr 62, D-70174 Stuttgart, Germany
Feuchtgruber, Simone (författare)
Olga Hosp, Klinikum Stuttgart, Pediat Oncol Hematol Immunol 5, Kriegsbergstr 62, D-70174 Stuttgart, Germany
Henssen, Anton (författare)
Charite Univ Med Berlin, Dept Pediat Hematol & Oncol, Berlin, Germany
Sparber-Sauer, Monika (författare)
Olga Hosp, Klinikum Stuttgart, Pediat Oncol Hematol Immunol 5, Kriegsbergstr 62, D-70174 Stuttgart, Germany
Eggert, Angelika (författare)
Charite Univ Med Berlin, Dept Pediat Hematol & Oncol, Berlin, Germany
Handgretinger, Ruppert (författare)
Univ Hosp Tuebingen, Univ Childrens Hosp, Dept Pediat Hematol & Oncol, Tubingen, Germany
Pekrun, Arnulf (författare)
Hosp Bremen Mitte, Dept Pediat Hematol & Oncol, Bremen, Germany
Rossig, Claudia (författare)
Univ Childrens Hosp Muenster, Dept Pediat Hematol & Oncol, Munster, Germany
Rutkowski, Stefan (författare)
Univ Hamburg Eppendorf, Pediat Hematol & Oncol, Hamburg, Germany
Schlegel, Paul-Gerhardt (författare)
Univ Wurzburg, Univ Childrens Hosp, Pediat Oncol, Stem Cell Transplantat, Wurzburg, Germany
Schrappe, Martin (författare)
Univ Hosp Schleswig Holstein, Dept Pediat, Campus Kiel, Kiel, Germany
Simon, Thorsten (författare)
Univ Childrens Hosp Cologne, Med Fac, Dept Pediat Oncol & Hematol, Cologne, Germany
Kazanowska, Bernarda (författare)
Univ Wroclaw, Dept Pediat Oncol, Wroclaw, Poland
Niggli, Felix (författare)
Univ Zuerich, Dept Pediat Oncol, Zurich, Switzerland
Ladenstein, Ruth (författare)
St Anna Childrens Hosp, Vienna, Austria;St Anna Kinderkrebsforsch eV, Vienna, Austria
Ljungman, Gustaf, 1958- (författare)
Uppsala universitet,Barnneurologi/Barnonkologi
Jahnukainen, Kirsi (författare)
Univ Helsinki, New Childrens Hosp, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland
Fuchs, Joerg (författare)
Univ Childrens Hosp, Dept Pediat Surg & Urol, Tubingen, Germany
Bielack, Stefan S. (författare)
Olga Hosp, Klinikum Stuttgart, Pediat Oncol Hematol Immunol 5, Kriegsbergstr 62, D-70174 Stuttgart, Germany;Univ Childrens Hosp Muenster, Dept Pediat Hematol & Oncol, Munster, Germany
Koscielniak, Ewa (författare)
Olga Hosp, Klinikum Stuttgart, Pediat Oncol Hematol Immunol 5, Kriegsbergstr 62, D-70174 Stuttgart, Germany;Univ Hosp Tuebingen, Univ Childrens Hosp, Dept Pediat Hematol & Oncol, Tubingen, Germany
Klingebiel, Thomas (författare)
Goethe Univ, Hosp Children & Adolescents, Frankfurt, Germany
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 (creator_code:org_t)
2020-01-13
2020
Engelska.
Ingår i: Journal of Cancer Research and Clinical Oncology. - : SPRINGER. - 0171-5216 .- 1432-1335. ; 146:4, s. 953-960
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Older age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown.Methods: SS patients < 21 years registered in consecutive CWS trials over the period of 1981-2018 were evaluated. Characteristics were analyzed according to age groups using the Fisher's exact test.Results: The study population included 432 SS patients. Disease characteristics differed according to age groups of children (0-12 years, n = 176), adolescents (13-16 years, n = 178), and young adults (17-21 years, n = 78). The proportion of invasive tumors (T2) was significantly higher in older patients: children 33%, adolescents 39% and young adults 54%, p = 0.009805. Similarly, the proportion of tumors > 10 cm was higher (13%, 21%, 31%; p = 0.005657) whereas conversely, the proportion of small tumors < 3 cm was lower in older patients (29%, 24%, 6%; p = 0.000104). The presence of metastases at first diagnosis was also highest in older patients (6%, 10%, 21%, p = 0.000963). Notably, the proportion of thigh tumors was higher in older patients (p = 0.04173), whereas the proportion of head-neck tumors was lower in older patients (p = 0.08896).Conclusions The rates of large, invasive tumors and the presence of metastases are significantly associated with older patient age. Localization to the thigh is more frequent in older patients.Discussion The causes for these variations require further exploration.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Synovial sarcoma
Soft tissue sarcoma
Pediatric sarcoma
Age
Age dependency

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