IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo

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Yamamoto-Hanada, KiwakoNatl Ctr Child Hlth & Dev, Allergy Ctr, Tokyo 1578535, Japan. (författare)

IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo

Artikel/kapitelEngelska2020

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Elsevier,2020
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LIBRIS-ID:oai:DiVA.org:uu-409853
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409853URI
https://doi.org/10.1016/j.waojou.2020.100105DOI

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Språk:engelska
Sammanfattning på:engelska

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Background: Response patterns to allergen components among Japanese children have not been studied extensively. Objective: Our aim was to examine the differences in sensitization patterns at ages 5 years and 9 years to identify longitudinal changes in the degree and patterns of sensitization in a birth cohort of Japanese children. Methods: Our study enrolled 984 children at aged 5 years between 2008 and 2010, and 729 children aged 9 years between 2012 and 2014. Allergic diseases were assessed using the ISAAC and UK Working Party's Diagnostic Criteria. Serum-specific IgE titers to allergen components were measured by multiplex array ImmunoCAP ISAC when the children were aged 5 and 9 years. Principal component analysis (PCA) was performed to characterize IgE sensitization to allergen components. Results: The prevalence of allergic rhinitis increased considerably over time (10.6%-31.2%). Furthermore, the sensitization prevalence to allergen-specific IgE (sIgE) also increased from 57.8% at age 5 years to 74.8% at age 9 years. IgE sensitization prevalence to Der f 1 (mites) was 42.1% at age 5 years and 54.3% at age 9 years. Furthermore, children were highly sensitized to Cry j 1 (Japanese cedar) (32.8% at age 5 years and 57.8% at age 9 years). Principle component analysis showed that sensitization to PR-10 cross-reactive components was independent of sensitization to mite and that no children acquired sensitization to pollen before acquiring sensitization to mite. Conclusions: The prevalence of allergic rhinitis and related allergen components increased from age 5 years to age 9 years in Japanese children.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
Allergy
Asthma
Atopic dermatitis
Child
Cohort
Eczema
IgE
ISAAC
ISAC
Prospective birth cohort
Rhinitis
Sensitization
Wheeze

Biuppslag (personer, institutioner, konferenser, titlar ...)

Borres, Magnus P,1956-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Thermo Fisher Sci, Uppsala, Sweden.(Swepub:uu)magbo385 (författare)
Åberg, Magnus K.Thermo Fisher Sci, Uppsala, Sweden. (författare)
Yang, LiminNatl Ctr Child Hlth & Dev, Allergy Ctr, Tokyo 1578535, Japan. (författare)
Fukuie, TatsukiNatl Ctr Child Hlth & Dev, Allergy Ctr, Tokyo 1578535, Japan. (författare)
Narita, MasamiNatl Ctr Child Hlth & Dev, Allergy Ctr, Tokyo 1578535, Japan. (författare)
Saito, HirohisaNatl Res Inst Child Hlth & Dev, Dept Allergy & Immunol, Tokyo, Japan. (författare)
Ohya, YukihiroNatl Ctr Child Hlth & Dev, Allergy Ctr, Tokyo 1578535, Japan. (författare)
Natl Ctr Child Hlth & Dev, Allergy Ctr, Tokyo 1578535, Japan.Institutionen för kvinnors och barns hälsa (creator_code:org_t)

Sammanhörande titlar

Ingår i:World Allergy Organization Journal: Elsevier13:21939-4551

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Av författaren/redakt...: Yamamoto-Hanada, ...; Borres, Magnus P ...; Åberg, Magnus K.; Yang, Limin; Fukuie, Tatsuki; Narita, Masami; visa fler...; Saito, Hirohisa; Ohya, Yukihiro; visa färre...

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