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T-cell acute lympho...
T-cell acute lymphoblastic leukemia in patients 1-45 years treated with the pediatric NOPHO ALL2008 protocol
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- Quist-Paulsen, P. (author)
- Univ Trondheim Hosp, St Olavs Hosp, Dept Hematol, Trondheim, Norway.
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- Toft, N. (author)
- Univ Copenhagen, Herlev Univ Hosp, Dept Hematol, Herlev, Denmark.
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- Heyman, M. (author)
- Karolinska Institutet
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- Abrahamsson, Jonas, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Griskevicius, L. (author)
- Vilnius Univ, Vilnius Univ Hosp Santaros Klinikos, Hematol Oncol & Transfus Med Ctr, Vilnius, Lithuania.
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- Hallböök, Helene (author)
- Uppsala universitet,Hematologi
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- Jonsson, O. G. (author)
- Landspitali Univ Hosp, Childrens Hosp, Reykjavik, Iceland.
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- Palk, K. (author)
- North Estonia Med Ctr, Dept Hematol, Tallinn, Estonia.
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- Vaitkeviciene, G. (author)
- Vilnius Univ, Vilnius Univ Hosp Santariskiu Klinikos, Childrens Hosp, Ctr Pediat Oncol & Hematol, Vilnius, Lithuania.
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- Vettenranta, K. (author)
- Helsinki Univ Cent Hosp, Hosp Children & Adolescents, Div Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland.
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- Asberg, A. (author)
- Univ Trondheim Hosp, St Olavs Hosp, Dept Pediat, Trondheim, Norway.
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- Frandsen, T. L. (author)
- Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.
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- Opdahl, S. (author)
- NTNU, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, Trondheim, Norway.
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- Marquart, H. V. (author)
- Univ Hosp, Rigshosp, Dept Clin Immunol, Sect 7631, Copenhagen, Denmark.,Umea Univ, Dept Med Biosci Pathol, Umea, Sweden.
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- Siitonen, S. (author)
- Helsinki Univ Cent Hosp, Dept Clin Chem, Helsinki, Finland.
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- Osnes, L. T. (author)
- Oslo Univ Hosp, Dept Immunol, Oslo, Norway.
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- Hultdin, Magnus (author)
- Umeå universitet,Patologi
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- Overgaard, U. M. (author)
- Univ Hosp, Rigshosp, Dept Hematol, Copenhagen, Denmark.
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- Wartiovaara-Kautto, U. (author)
- Helsinki Univ Hosp, Comprehens Canc Ctr, Dept Hematol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
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- Schmiegelow, K. (author)
- Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Fac Med, Inst Clin Med, Copenhagen, Denmark.
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Univ Trondheim Hosp, St Olavs Hosp, Dept Hematol, Trondheim, Norway Univ Copenhagen, Herlev Univ Hosp, Dept Hematol, Herlev, Denmark. (creator_code:org_t)
- 2019-10-14
- 2020
- English.
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In: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 34:2, s. 347-357
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- The NOPHO ALL2008 is a population-based study using an unmodified pediatric protocol in patients 1-45 years of age with acute lymphoblastic leukemia. Patients with T-ALL were given a traditional pediatric scheme if fast responding (minimal residual disease (MRD) < 0.1% day 29), or intensive block-based chemotherapy if slow responding (MRD > 0.1% day 29). Both treatment arms included pediatric doses of high-dose methotrexate and asparaginase. If MRD >= 5% on day 29 or >= 0.1% after consolidation, patients were assigned to allogeneic hematopoietic stem cell transplantation. The 5-year overall survival of the 278 T-ALL patients was 0.75 (95% CI 0.69-0.81), being 0.82 (0.74-0.88) for patients 1.0-9.9 years, 0.76 (0.66-0.86) for those 10.0-17.9 years, and 0.65 (0.55-0.75) for the older patients. The risk of death in first remission was significantly higher in adults (12%) compared with the 1-9 years group (4%). The MRD responses in the three age groups were similar, and only a nonsignificant increase in relapse risk was found in adults. In conclusion, an unmodified pediatric protocol in patients 1-45 years is effective in all age groups. The traditional pediatric treatment schedule was safe for all patients, but the intensive block therapy led to a high toxic death rate in adults.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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- ref (subject category)
- art (subject category)
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Leukemia
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- By the author/editor
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Quist-Paulsen, P ...
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Toft, N.
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Heyman, M.
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Abrahamsson, Jon ...
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Griskevicius, L.
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Hallböök, Helene
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show more...
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Jonsson, O. G.
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Palk, K.
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Vaitkeviciene, G ...
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Vettenranta, K.
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Asberg, A.
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Frandsen, T. L.
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Opdahl, S.
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Marquart, H. V.
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Siitonen, S.
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Osnes, L. T.
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Hultdin, Magnus
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Overgaard, U. M.
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Wartiovaara-Kaut ...
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Schmiegelow, K.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Leukemia
- By the university
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Uppsala University
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Umeå University
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Karolinska Institutet
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University of Gothenburg